Unii-na83F1sjsr

ChemicalBook > CAS DataBase List > Unii-na83F1sjsr

Product Name: Unii-na83F1sjsr
CAS No.: 706782-28-7
Chemical Name: Unii-na83F1sjsr
Synonyms: PiMavanserin Tartrate;Nuplazid;ACP-103;BVF-048;Unii-na83F1sjsr;ACP-103 tartrate;8-Octanedioic acid;Pimavanserin tartrare;Pimavanserin tartrate vv;Pimavanserin L-Hetartrate
CBNumber: CB32494118
Molecular Formula: C29H40FN3O8
Formula Weight: 577.65
MOL File: 706782-28-7.mol

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Unii-na83F1sjsr Property

storage temp.: Store at -20°C
solubility: DMSO:70.0(Max Conc. mg/mL);69.6(Max Conc. mM)

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Safety

HS Code: 29299090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H317May cause an allergic skin reaction

H318Causes serious eye damage

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: P441810
Product name: PimavanserinTartrate
Packaging: 5mg
Price: $160
Updated: 2021/12/16

AK Scientific

Product number: 4806BB
Product name: Pimavanserintartrate
Packaging: 10mg
Price: $164
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BP164269
Product name: Pimavanserin tartrate
Packaging: 50mg
Price: $297.5
Updated: 2021/12/16

ChemScene

Product number: CS-7954
Product name: Pimavanserintartrate
Purity: 99.47%
Packaging: 25mg
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-7954
Product name: Pimavanserintartrate
Purity: 99.47%
Packaging: 50mg
Price: $80
Updated: 2021/12/16

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Unii-na83F1sjsr Chemical Properties,Usage,Production

Description

Pimavanserin, developed by San Diego-based Acadia Pharmaceuticals, is a selective and potent serotonin 2A (5-HT2A) receptor inverse agonist. The USFDA approved this once-daily drug to treat the delusions and hallucinations associated with psychosis as a function of Parkinson’s disease. Pimavanserin has a unique mechanism of action relative to other antipsychotics, behaving as a selective inverse agonist of the serotonin 5-HT2A receptor while exhibiting 40-fold selectivity over the 5-HT2C receptor and having no significant affinity or activity with the 5-HT2B or dopamine receptors.

Uses

Pimavanserin tartrate is a 5-HT2A inverse agonist that reverses psychosis-like behaviours and has the potential to treat various other neuropsychiatric disorders such as schizophrenia and Parkinson’s disease.

Definition

ChEBI: A tartrate salt that is the hemitartrate salt of pimavanserin. An atypical antipsychotic that is used for treatment of hallucinations and delusions associated with Parkinson's disease.

Synthesis

Three patent applications filed by Acadia described the process-scale synthetic approach to pimavanserin. The kilogram-scale synthesis began with the alkylation of commercially available 4-hydroxybenzaldehyde (123) with isobutyl bromide (124) under basic conditions. Condensation of the resultant benzaldehyde 125 with hydroxylamine furnished the corresponding oxime 126 in 63% yield from 123. Hydrogenation of 126 catalyzed by Pd/C under acidic conditions produced benzylamine 127, which was isolated as the acetate salt in 41% yield. This compound underwent sodium hydroxide workup followed by reaction with HCl gas and phosgene to deliver isocyanate 128. Nucleophilic attack of this isocyanate by benzylamine 129 (prepared from reductive amination of commercially available N-methylpiperid-4-one 130 with 4-fluorobenzylamine 131) followed by salt formation using tartaric acid in aqueous isopropyl acetate, and THF completed the synthesis of pimavanserin tartrate (XI) in 50% yield over the two-step protocol and a 10.6% overall yield from 123.

Unii-na83F1sjsr Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Unii-na83F1sjsr manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Pimavanserin Impurity reference 706782-28-7
Price: US $0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 10g
Release date: 2024-03-27

Hangzhou ICH Biofarm Co., Ltd

Product: Pimavanserin Tartrate 706782-28-7
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 100kg
Release date: 2023-07-04

Shenzhen Excellent Biotech Co., Ltd.

Product: Pimavanserin Tartrate 706782-28-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5000KG
Release date: 2020-08-21

706782-28-7, Unii-na83F1sjsrRelated Search:

L(+)-Ornithine hydrochloride Pimavanserin 1,3-bis(4-isobutoxybenzyl)urea Bis(4-fluorobenzyl)aMine Pimavanserin N-[(4-Fluorophenyl)methyl]-1-methyl-4-piperidinamine Pimavanserin

N-(4-Fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) carbamide (2R,3R)-dihydroxybutanedioate (2:1)

N-(4-Fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl)carbamide

Unii-na83F1sjsr

PiMavanserin Tartrate

Pimavanserin tartrate or ACP 103

ACP-103

BVF-048

Nuplazid

Pimavanserin tartrate,nuplazid

N-[(4-Fluorophenyl)methyl]-N-(1-methyl-4-piperidinyl)-N'-[[4-(2-methylpropoxy)phenyl]methyl]urea (2R,3R)-2,3-dihydroxybutanedioate (2:1)

N-[(4-Fluorophenyl)methyl]-N-(1-methyl-4-piperidinyl)-N'-[[4-(2-methylpropoxy)phenyl]methyl]urea (2R,3R)-2,3-dihydroxybutanedioate

Urea,N-[(4-fluorobenzyl)methyl]-N-(1-methyl-4-piperidinyl)-N'-[[4-(2-methylpropoxy)phenyl]methyl]-,(2R,3R)-2,3-dihydroxybutanediooate(2:1)

ACP-103 tartrate

1-(4-fluorobenzyl)-3-(4-isobutoxybenzyl)-1-(1-methylpiperidin-4-yl)urea hemi((2R,3R)-2,3-dihydroxysuccinate)

Pimavanserin tartrare

Pimavanserin Impurity reference

8-Octanedioic acid

Pimo van Serine L-tartrate

Pimavanserin tartaric acid

Pimavanserin tartrate vv

Pimavanserin L-Hetartrate

706782-28-7

2C25H34FN3O2C4H6O6

C54H74F2N6O10