ChemicalBook > CAS DataBase List > Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-, monohydrochloride

Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-, monohydrochloride

Product Name
Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-, monohydrochloride
CAS No.
98206-09-8
Chemical Name
Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-, monohydrochloride
Synonyms
CS-1200;DU 28893;DU-28853 HYDROCHLORIDE;Eltoprazine hydrochloride, 10 mM in DMSO;Eltoprazine hydrochloride (DU-28853 hydrochloride);Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-, monohydrochloride;DU-28853,5-hydroxytryptamine Receptor,Inhibitor,DU 28853,5-HT Receptor,DU28853,inhibit,Eltoprazine hydrochloride,Serotonin Receptor,Eltoprazine
CBNumber
CB32495074
Molecular Formula
C12H16N2O2.ClH
Formula Weight
256.731
MOL File
98206-09-8.mol
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Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-, monohydrochloride Property

Melting point:
256-258°
storage temp. 
Store at -20°C
solubility 
DMSO:25.5(Max Conc. mg/mL);99.33(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);116.85(Max Conc. mM)
Ethanol:25.0(Max Conc. mg/mL);97.38(Max Conc. mM)
PBS (pH 7.2):1.0(Max Conc. mg/mL);3.9(Max Conc. mM)
Water:100.0(Max Conc. mg/mL);389.51(Max Conc. mM)
form 
A crystalline solid
color 
White to off-white
Water Solubility 
H2O: 10mg/mL, clear
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1526
Product name
Eltoprazine hydrochloride
Purity
≥98% (HPLC)
Packaging
25 mg
Price
$372.4
Updated
2025/07/31
Cayman Chemical
Product number
18428
Product name
Eltoprazine (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$26
Updated
2024/03/01
Cayman Chemical
Product number
18428
Product name
Eltoprazine (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$96
Updated
2024/03/01
Cayman Chemical
Product number
18428
Product name
Eltoprazine (hydrochloride)
Purity
≥98%
Packaging
25 mg
Price
$351
Updated
2024/03/01
Cayman Chemical
Product number
18428
Product name
Eltoprazine (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$179
Updated
2024/03/01
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Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-, monohydrochloride Chemical Properties,Usage,Production

Uses

5-HT1 and 5-HT2C receptor partial agonist that has been shown to reduce 5-HIAA levels in the striatum and exhibits antiaggressive behavior in vivo. A novel drug for the treatment of anxiety as well as other neurological and mental disorders.

Biological Activity

Eltoprazine hyrochloride is a serotonin 5-HT1A/1B receptor agonist th at has been shown to reduce L-DOPA-induced dyskinesias in in experimental models of Parkinsonμs Disease and in human patients. It has Ki values for 5-HT1A, 5-HT1B and 5-HT1C receptors of 40 nM and 52 nM, respectively.

in vivo

Rats are chronically treated with Mianserin (10 mg/kg i.p.) or Eltoprazine (1 mg/kg i.p.) and are tested in the elevated plus-maze test for anxiety. Mianserin and Eltoprazine display opposite effects in the elevated plus-maze: Mianserin induces anxiolytic-like effects, while Eltoprazine shows anxiogenic-like ones[2].

IC 50

5-HT1A Receptor; 5-HT1B Receptor; 5-HT2C Receptor

Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-, monohydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-, monohydrochloride Suppliers

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98206-09-8, Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-, monohydrochlorideRelated Search:

2,3-Dihydrofuran Phthalan 1-(2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL)-PIPERAZINE HYDROCHLORIDE

  • Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-, monohydrochloride
  • DU 28893
  • DU-28853 HYDROCHLORIDE
  • CS-1200
  • Eltoprazine hydrochloride (DU-28853 hydrochloride)
  • DU-28853,5-hydroxytryptamine Receptor,Inhibitor,DU 28853,5-HT Receptor,DU28853,inhibit,Eltoprazine hydrochloride,Serotonin Receptor,Eltoprazine
  • Eltoprazine hydrochloride, 10 mM in DMSO
  • 98206-09-8
  • RU-24969
  • Agonist
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals