PYRVINIUM PAMOATE
Pharmacology and mechanism of action Indications Side effects Preparations References- Product Name
- PYRVINIUM PAMOATE
- CAS No.
- 3546-41-6
- Chemical Name
- PYRVINIUM PAMOATE
- Synonyms
- tru;povan;pyrcon;Poquil;povanyl;altolat;alnoxin;molevac;pamovin;sn-4395
- CBNumber
- CB3249600
- Molecular Formula
- C75H70N6O6
- Formula Weight
- 1151.39
- MOL File
- 3546-41-6.mol
PYRVINIUM PAMOATE Property
- Melting point:
- 210-215° (softens at 190°)
- Boiling point:
- 829.27°C (rough estimate)
- Density
- 1.0104 (rough estimate)
- refractive index
- 1.6400 (estimate)
- storage temp.
- 2-8°C
- solubility
- DMSO: >10mg/mL
- form
- powder
- color
- red
- EPA Substance Registry System
- Pyrvinium pamoate (3546-41-6)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38-40
- Safety Statements
- 26-36
- WGK Germany
- 3
- HS Code
- 2933492250
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H351Suspected of causing cancer
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- P0027
- Product name
- Pyrvinium pamoate salt hydrate
- Purity
- ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $142
- Updated
- 2024/03/01
- Product number
- P0027
- Product name
- Pyrvinium pamoate salt hydrate
- Purity
- ≥98% (HPLC)
- Packaging
- 50mg
- Price
- $557
- Updated
- 2024/03/01
- Product number
- P999010
- Product name
- Pyrvinium pamoate
- Packaging
- 100mg
- Price
- $445
- Updated
- 2021/12/16
- Product number
- orb573378
- Product name
- pyrvinium
- Purity
- >98%
- Packaging
- 100mg
- Price
- $542.3
- Updated
- 2021/12/16
- Product number
- orb611523
- Product name
- Pyrvinium pamoate
- Packaging
- 250mg
- Price
- $615.4
- Updated
- 2021/12/16
PYRVINIUM PAMOATE Chemical Properties,Usage,Production
Pharmacology and mechanism of action
Pyrvinium is a quaternary ammonium derivative of a cyanine dye with marked effect against Enterobius vermicularis.
The mechanism of action is not well known. The drug inhibits oxidative metabolism in the worms and interferes with the absorption of glucose in intestinal helminths. Since most intestinal worms are dependent on anaerobic carbohydrate metabolism, this may be an important action of the drug[1].
Indications
Infections caused by Enterobius vermicularis. Pyrvinium is largely replaced today by more effective and safer drugs such as albendazole and mebendazole.
Side effects
Gastrointestinal disturbances such as nausea, vomiting, dyspepsia, indigestion and abdominal pain are frequent. Allergic reactions and photosensitivity have been reported. Pyrvinium stains the stool bright red and may stain clothing if vomiting occurs. Patients should be informed about this.
Preparations
Pyrvinium pamoate (embonate): 450 mg of the pamoate is equivalent to 300 mg of pyrvinium.
• Povanyl ® (Parke-Davis). Oral solution 10 mg pyrvinium per ml. Tablets 50 mg pyrvinium.
• Vanquin® (Parke-Davis). Oral solution 10 mg pyrvinium per ml. Tab pyrvinium.
References
1. Buchanan RA, Barrow WB, Heffelfinger JC, Kinkel AW, Smith TC, Turner JL (1974). Pyrvinium pamoate. Clin Pharmacol Ther, 16, 716–719.
Description
Pyrvinium is a tasteless, odorless, bright orange to black, crystalline solid. It is insoluble in water or ether, slightly soluble in chloroform, and soluble in glacial acetic acid.
Uses
anthelmintic
Uses
Pyrvinium Pamoate is a potent noncompetitive inhibitor of the androgen receptor, with the application towards prostate cancer treatment. Antihelmintic.
Definition
ChEBI: Pyrvinium pamoate is a naphthoic acid. It has a role as an anticoronaviral agent.
Indications
The cation is the active part of the compound. Pyrvinium is used against pinworms (Enterobius).
brand name
Povan (Parke-Davis).
General Description
Odorless bright orange or orange-red to brownish red or almost black fluffy powder. Melting point 210-215°C. Insoluble in water. Tasteless.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
PYRVINIUM PAMOATE is light sensitive. Incompatible with strong oxidizing agents, strong acids and bases .
Fire Hazard
Flash point data for PYRVINIUM PAMOATE are not available; however, PYRVINIUM PAMOATE is probably combustible.
Biochem/physiol Actions
Pyrvinium pamoate is a potent androgen receptor inhibitor. Androgen receptors (ARs) are nuclear hormone receptors/transcription factors that reside in the cytoplasm and activated by testosterone and dihydrotestosterone. AR inhibitors have potential therapeutic benefit in prostate cancer; competitive inhibitors and chemical castration methods have been discovered, but both therapies have undesirable side effects and/or resistance potential. A screen for non-competitive inhibitors was performed, resulting in the discovery of pyrvinium as an AR inhibitor. In comparison to competitive inhibitors, this compound does not bind to the ligand-binding domain of AR or block DNA occupancy by AR, but it inhibits AR-dependent gene expression via a distinct signaling mechanism. It is more potent than classical competitive AR antagonists and exhibits synergy with other AR inhibitors.
Side effects
Occasional adverse reactions are blood dyscrasia and folic acid deficiency. Rare adverse reactions are rash, vomiting, convulsion, shock, photosensitivity, and headache.
PYRVINIUM PAMOATE Preparation Products And Raw materials
Raw materials
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View Lastest Price from PYRVINIUM PAMOATE manufacturers
- Product
- PYRVINIUM PAMOATE 3546-41-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-06-18
- Product
- Pyrvinium Pamoate 3546-41-6
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 500 tons
- Release date
- 2020-04-27
- Product
- PYRVINIUM PAMOATE 3546-41-6
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- 10kg
- Release date
- 2018-12-18