1-Acetyl-3-hydroxyazetidine

Product Name: 1-Acetyl-3-hydroxyazetidine
CAS No.: 118972-96-6
Chemical Name: 1-Acetyl-3-hydroxyazetidine
Synonyms: 1-acetylazetidin-3-ol;1-acetyl-3-Azetidinol;1-(3-Hydroxyazetidin-1-yl);1-Acetyl-3-hydroxyazetidine;1-(3-Hydroxyazetidin-1-yl)ethanone;1-ethylacyl-3-hydroxyazacyclobutane;1-(3-Hydroxy-1-azetidinyl)-ethanone;1-(3-hydroxyazetidin-1-yl)ethan-1-one;Ethanone, 1-(3-hydroxy-1-azetidinyl)-;1-Acetyl-3-hydroxyazetidine - [A15322]
CBNumber: CB32498262
Molecular Formula: C5H9NO2
Formula Weight: 115.13
MOL File: 118972-96-6.mol

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1-Acetyl-3-hydroxyazetidine Property

Boiling point:: 275.9±33.0 °C(Predicted)
Density: 1.275±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 13.31±0.20(Predicted)
Appearance: Off-white to light yellow Solid

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A145300
Product name: 1-Acetyl-3-hydroxyazetidine
Packaging: 100mg
Price: $50
Updated: 2021/12/16

TRC

Product number: A145300
Product name: 1-Acetyl-3-hydroxyazetidine
Packaging: 1g
Price: $210
Updated: 2021/12/16

Usbiological

Product number: 408679
Product name: 1-Acetyl-3-hydroxyazetidine
Packaging: 100mg
Price: $312
Updated: 2021/12/16

Synthonix

Product number: A15322
Product name: 1-Acetyl-3-hydroxyazetidine
Purity: 95+%
Packaging: 1g
Price: $90
Updated: 2021/12/16

Apolloscientific

Product number: OR451031
Product name: 1-(3-Hydroxy-1-azetidinyl)-ethanone
Purity: 95%
Packaging: 1g
Price: $167
Updated: 2021/12/16

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1-Acetyl-3-hydroxyazetidine Chemical Properties,Usage,Production

Synthesis

45347-82-8

75-36-5

118972-96-6

Step 1 - Synthesis of 1-(3-hydroxyazetidin-1-yl)ethan-1-one: Azetidin-3-ol (3.0 g, 27.40 mmol) and triethylamine (8.33 g, 82.48 mmol) were dissolved in tetrahydrofuran (150 mL) and stirred for 10 min at -78°C. Slowly, acetyl chloride (2.15 g, 27.39 mmol) was added dropwise. Acetyl chloride (2.15 g, 27.39 mmol) was added slowly dropwise, keeping the reaction temperature at -78°C. After completion of the dropwise addition, the reaction mixture was warmed up to 20-30°C and stirring was continued for 3 hours. After completion of the reaction, the insoluble solids were removed by filtration. The filtrate was concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography with the eluent methanol/ethyl acetate (1/10, v/v) to afford 500 mg (14% yield) of 1-(3-hydroxyazetidin-1-yl)ethan-1-one as a yellow oil. The product was characterized by 1H NMR (400 MHz, DMSO): δ 3.60 (t, J = 4.8 Hz, 2H), 2.83 (t, J = 4.8 Hz, 2H), 2.21 (s, 3H).

References

[1] Patent: US2012/214762, 2012, A1. Location in patent: Page/Page column 169
[2] Patent: US5130309, 1992, A

1-Acetyl-3-hydroxyazetidine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Acetyl-3-hydroxyazetidine Suppliers

China 72 Germany 1 India 1 United Kingdom 1 United States 8 Global 83

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View Lastest Price from 1-Acetyl-3-hydroxyazetidine manufacturers

Henan Fengda Chemical Co., Ltd

Product: 1-Acetyl-3-hydroxyazetidine 118972-96-6
Price: US $101.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-28

Career Henan Chemical Co

Product: 1-Acetyl-3-hydroxyazetidine 118972-96-6
Price: US $0.01/KG
Min. Order: 1KG
Purity: 98%; 99%
Supply Ability: 1kg; 10kg; 25kg
Release date: 2020-01-07

118972-96-6, 1-Acetyl-3-hydroxyazetidineRelated Search:

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1-(3-Hydroxyazetidin-1-yl)ethanone

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1-Acetyl-3-hydroxyazetidine

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1-acetylazetidin-3-ol

Ethanone, 1-(3-hydroxy-1-azetidinyl)-

1-Acetyl-3-hydroxyazetidine - [A15322]

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118972-96-6