3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide

ChemicalBook > CAS DataBase List > 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide

3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide

Product Name: 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide
CAS No.: 781652-57-1
Chemical Name: 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide
Synonyms: CDPPB;mGluR5 Ligand, CDPPB;CDPPB, 10 mM in DMSO;CDPPB, positive allosteric modulator for mGlu5;3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide;mGluR5 Ligand, CDPPB - CAS 781652-57-1 - Calbiochem;Benzamide, 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)-
CBNumber: CB32498277
Molecular Formula: C23H16N4O
Formula Weight: 364.4
MOL File: 781652-57-1.mol

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3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide Property

Melting point:: 210-212°C
storage temp.: 2-8°C
solubility: DMSO: ≥5mg/mL at warmed to 60°C
form: powder
color: white to beige

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0235
Product name: CDPPB
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $113
Updated: 2024/03/01

Sigma-Aldrich

Product number: 445865
Product name: mGluR5 Ligand, CDPPB
Packaging: 1mg
Price: $129
Updated: 2022/05/15

Sigma-Aldrich

Product number: SML0235
Product name: CDPPB
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $579
Updated: 2024/03/01

Tocris

Product number: 3235
Product name: CDPPB
Purity: ≥98%(HPLC)
Packaging: 10
Price: $195
Updated: 2021/12/16

Tocris

Product number: 3235
Product name: CDPPB
Purity: ≥98%(HPLC)
Packaging: 50
Price: $818
Updated: 2021/12/16

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3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide Chemical Properties,Usage,Production

Uses

CDPPB may be used in mGluR5-mediated cell signaling studies.

Uses

3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide is a glutamate metabotropic (mGluR5) positive allosteric modulator, used in the treatment of Phelan-McDermid syndrome caused by 22qI3 deletion. Studies have shown that 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide suppresses the incre ase of LDH release and caspase-3 activation induced by traumatic neuronal injury.

Biochem/physiol Actions

CDPPB is a glutamate metabotropic mGluR5 positive allosteric modulator.

storage

+4°C

3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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781652-57-1, 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamideRelated Search:

FORMANILIDE Acetanilide 1H-Benzotriazole

3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide

CDPPB

mGluR5 Ligand, CDPPB

mGluR5 Ligand, CDPPB - CAS 781652-57-1 - Calbiochem

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CDPPB, positive allosteric modulator for mGlu5

CDPPB, 10 mM in DMSO

781652-57-1