ChemicalBook > CAS DataBase List > 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide

3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide

Product Name
3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide
CAS No.
781652-57-1
Chemical Name
3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide
Synonyms
CDPPB;mGluR5 Ligand, CDPPB;3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide;mGluR5 Ligand, CDPPB - CAS 781652-57-1 - Calbiochem;Benzamide, 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)-
CBNumber
CB32498277
Molecular Formula
C23H16N4O
Formula Weight
364.4
MOL File
781652-57-1.mol
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3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide Property

Melting point:
210-212°C
storage temp. 
2-8°C
solubility 
DMSO: ≥5mg/mL at warmed to 60°C
form 
powder
color 
white to beige
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0235
Product name
CDPPB
Purity
≥98% (HPLC)
Packaging
5mg
Price
$113
Updated
2024/03/01
Sigma-Aldrich
Product number
445865
Product name
mGluR5 Ligand, CDPPB
Packaging
1mg
Price
$129
Updated
2022/05/15
Sigma-Aldrich
Product number
SML0235
Product name
CDPPB
Purity
≥98% (HPLC)
Packaging
25mg
Price
$579
Updated
2024/03/01
Tocris
Product number
3235
Product name
CDPPB
Purity
≥98%(HPLC)
Packaging
10
Price
$195
Updated
2021/12/16
Tocris
Product number
3235
Product name
CDPPB
Purity
≥98%(HPLC)
Packaging
50
Price
$818
Updated
2021/12/16
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3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide Chemical Properties,Usage,Production

Uses

CDPPB may be used in mGluR5-mediated cell signaling studies.

Uses

3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide is a glutamate metabotropic (mGluR5) positive allosteric modulator, used in the treatment of Phelan-McDermid syndrome caused by 22qI3 deletion. Studies have shown that 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide suppresses the incre ase of LDH release and caspase-3 activation induced by traumatic neuronal injury.

Biochem/physiol Actions

CDPPB is a glutamate metabotropic mGluR5 positive allosteric modulator.

storage

+4°C

3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide Suppliers

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781652-57-1, 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamideRelated Search:

FORMANILIDE Acetanilide 1H-Benzotriazole

  • 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide
  • CDPPB
  • mGluR5 Ligand, CDPPB
  • mGluR5 Ligand, CDPPB - CAS 781652-57-1 - Calbiochem
  • Benzamide, 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)-
  • 781652-57-1