DL-Propargylglycine

Product Name: DL-Propargylglycine
CAS No.: 16900-57-5
Chemical Name: DL-Propargylglycine
Synonyms: DL-Propargylglycine HCl;DL-2-Propynylglycine hydrochloride;2-Amino-4-pentynoic acid hydrochloride;2-Aminopent-4-ynoic acid hydrochloride;2-amino-4-pentynoic Acid Hydrochloride (1:1);DL-Propargyl Glycine HCl|||DL-Propargyl Glycine hydrochloride
CBNumber: CB32499254
Molecular Formula: C5H8ClNO2
Formula Weight: 149.57
MOL File: 16900-57-5.mol

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DL-Propargylglycine Property

storage temp.: Inert atmosphere,Room Temperature
solubility: DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 10 mg/ml
form: A crystalline solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10010948
Product name: DL-Propargyl Glycine (hydrochloride)
Purity: ≥95%
Packaging: 1mg
Price: $17
Updated: 2024/03/01

Cayman Chemical

Product number: 10010948
Product name: DL-Propargyl Glycine (hydrochloride)
Purity: ≥95%
Packaging: 5mg
Price: $67
Updated: 2024/03/01

Cayman Chemical

Product number: 10010948
Product name: DL-Propargyl Glycine (hydrochloride)
Purity: ≥95%
Packaging: 10mg
Price: $118
Updated: 2024/03/01

Cayman Chemical

Product number: 10010948
Product name: DL-Propargyl Glycine (hydrochloride)
Purity: ≥95%
Packaging: 50mg
Price: $510
Updated: 2024/03/01

Ark Pharm

Product number: AK323755
Product name: 2-Aminopent-4-ynoicacidhydrochloride
Purity: 97%
Packaging: 1g
Price: $68
Updated: 2021/12/16

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DL-Propargylglycine Chemical Properties,Usage,Production

Description

Hydrogen sulphide (H₂S), a naturally occurring gasotransmitter, is a potent vasodilator and pro-inflammatory mediator. DL-Propargyl glycine (PAG) is an irreversible inhibitor of the H₂S synthesizing enzyme cystathionine-γ-lyase (CSE). PAG blocks H₂S synthesis activity in rat liver preparations with an IC₅₀ value of 55 μM and abolishes the rise in plasma H₂S in anaesthetized rats induced with hemorrhagic shock. At concentrations ranging from 25-100 mg/kg, PAG can reduce H₂S-associated inflammation in rodent models of pancreatitis, oedema, and endotoxemia.

Uses

DL-Propargylglycine Hydrochloride is used in preparation of tert-Butoxycarbonyl Azide.

References

[1] MADHAV BHATIA. Pro-inflammatory effects of hydrogen sulphide on substance P in caerulein-induced acute pancreatitis[J]. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2007, 12 2: 580-590. DOI: 10.1111/j.1582-4934.2007.00131.x
[2] MADHAV BHATIA. Hydrogen sulphide is a mediator of carrageenan-induced hindpaw oedema in the rat[J]. British Journal of Pharmacology, 2009, 145 2: 141-144. DOI: 10.1038/sj.bjp.0706186
[3] MARIKA COLLIN. Inhibition of endogenous hydrogen sulfide formation reduces the organ injury caused by endotoxemia[J]. British Journal of Pharmacology, 2009, 146 4: 498-505. DOI: 10.1038/sj.bjp.0706367

DL-Propargylglycine Preparation Products And Raw materials

Raw materials

Preparation Products

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DL-Propargylglycine Suppliers

China 41 India 1 United States 6 Global 48

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
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Shanghai Hanhong Scientific Co.,Ltd.

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Bide Pharmatech Ltd.

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BOC Sciences

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Shanghai EFE Biological Technology Co., Ltd.

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Amadis Chemical Company Limited

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Aikon International Limited

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Bejing Famous Pharmaceutical Technology Co., Ltd.

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Shanghai Jizhi Biochemical Technology Co. Ltd.

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Shanghai Hongye Biotechnology Co. Ltd

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16900-57-5, DL-PropargylglycineRelated Search:

2-Aminopent-4-ynoic acid hydrochloride

DL-2-Propynylglycine hydrochloride

2-Amino-4-pentynoic acid hydrochloride

2-amino-4-pentynoic Acid Hydrochloride (1:1)

DL-Propargylglycine HCl

DL-Propargyl Glycine HCl|||DL-Propargyl Glycine hydrochloride

16900-57-5