ChemicalBook > CAS DataBase List > 2-Methoxy-5-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-pyridin-3-ylamine

2-Methoxy-5-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-pyridin-3-ylamine

Product Name
2-Methoxy-5-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-pyridin-3-ylamine
CAS No.
893440-50-1
Chemical Name
2-Methoxy-5-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-pyridin-3-ylamine
Synonyms
Omaveloxolone Impurity 3;3-Amino-2-methoxypyridin-5-ylboronic acid;2-Methoxy-3-aminopyridine-5-boronic acid pinacol ester;5-Amino-6-methoxypyridine-3-boronic acid pinacol ester;3-Amino-2-methoxypyridine-5-boronic acid pinacol ester;3-Amino-2-methoxypyridine-5-boronicacidpinacolester,96%;3-Amino-2-methoxypyridin-5-ylboronic acid pinacol ester;(5-amino-6-methoxypyridin-3-yl)boronic acid pinacol ester;2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl);3-AMino-2-Methoxypyridine-5-boronic acid pinacol ester, 96%
CBNumber
CB32499269
Molecular Formula
C12H19BN2O3
Formula Weight
250.1
MOL File
893440-50-1.mol
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2-Methoxy-5-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-pyridin-3-ylamine Property

Melting point:
131-133℃
Boiling point:
392.3±42.0 °C(Predicted)
Density 
1.11±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
form 
powder to crystal
pka
4.32±0.22(Predicted)
color 
White to Gray to Brown
Water Solubility 
Slightly soluble in water.
InChI
InChI=1S/C12H19BN2O3/c1-11(2)12(3,4)18-13(17-11)8-6-9(14)10(16-5)15-7-8/h6-7H,14H2,1-5H3
InChIKey
KYYKGOURQXPERA-UHFFFAOYSA-N
SMILES
C1(OC)=NC=C(B2OC(C)(C)C(C)(C)O2)C=C1N
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
A2993
Product name
3-Amino-2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Purity
>98.0%(GC)(T)
Packaging
200mg
Price
$75
Updated
2025/07/31
TCI Chemical
Product number
A2993
Product name
3-Amino-2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$219
Updated
2025/07/31
TRC
Product number
A628013
Product name
5-Amino-6-methoxypyridine-3-boronicacidpinacolester
Packaging
100mg
Price
$265
Updated
2021/12/16
TRC
Product number
A628013
Product name
5-Amino-6-methoxypyridine-3-boronicacidpinacolester
Packaging
250mg
Price
$470
Updated
2021/12/16
AK Scientific
Product number
Z5292
Product name
2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-amine
Packaging
25g
Price
$477
Updated
2021/12/16
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2-Methoxy-5-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-pyridin-3-ylamine Chemical Properties,Usage,Production

Uses

It is used as a pharmaceutical intermediate.

Synthesis

884495-39-0

73183-34-3

893440-50-1

Step A: Synthesis of 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-amine [00403] Degassed 5-bromo-2-methoxypyridin-3-amine (2 g, 9.85 mmol), 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl pinacol ester (3.00 g, 11.82 mmol), Pd(dppf)2Cl2-CH2Cl2 adduct (0.804 g, 0.985 mmol) and potassium acetate (3.87 g, 39.4 mmol) in 1,4-dioxane (50 mL) was heated at 100 °C for 18 h followed by stirring at room temperature overnight. Upon completion of the reaction, the mixture was filtered through a Celite pad and washed with EtOAc. The filtrate was concentrated and the residual solvent was removed by azeotropy with CH2Cl2/hexane. The crude product was dissolved in CH2Cl2 and purified by silica gel column chromatography (elution gradient: 0-100% EtOAc/hexane) to afford 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-amine (3.9 g, 9.36 mmol, 95% yield) as a light brown solid.1H NMR (400 MHz, DMSO-d6) was performed on a 1H NMR pad. MHz, DMSO-d6) δ ppm: 1.26 (s, 12H), 3.87 (s, 3H), 4.92 (s, 2H), 7.12 (d, J = 1.46 Hz, 1H), 7.63 (d, J = 1.37 Hz, 1H); ES LC-MS m/z = 251.4 (M + H)+.

References

[1] Patent: WO2012/174312, 2012, A2. Location in patent: Page/Page column 287
[2] Patent: WO2014/6554, 2014, A1. Location in patent: Page/Page column 43
[3] Journal of Medicinal Chemistry, 2014, vol. 57, # 5, p. 2091 - 2106
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 18, p. 7381 - 7399
[5] Patent: WO2014/60431, 2014, A1. Location in patent: Page/Page column 85

2-Methoxy-5-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-pyridin-3-ylamine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Methoxy-5-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-pyridin-3-ylamine Suppliers

Americas 1 Belgium 1 Canada 2 China 130 Europe 1 France 1 Germany 4 India 10 Japan 1 United Kingdom 4 United States 30 Global 185
TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75
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View Lastest Price from 2-Methoxy-5-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-pyridin-3-ylamine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
3-Amino-2-methoxypyridine-5-boronic acid pinacol ester 893440-50-1
Price
US $3.00-9.00/KG
Min. Order
0.1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2025-07-05
Career Henan Chemical Co
Product
2-Methoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-3-ylamine 893440-50-1
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg; 10kg; 100kg
Release date
2019-08-30

893440-50-1, 2-Methoxy-5-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-pyridin-3-ylamineRelated Search:


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  • 3-Amino-2-methoxypyridine-5-boronicacidpinacolester,96%
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  • Omaveloxolone Impurity 3
  • 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-amine - [M2346]
  • 3-Amino-2-methoxypyridine-5-boronic acid pinacol ester
  • 893440-50-1