3-Nitro-4-(trifluoromethoxyl)benzoic acid

Product Name: 3-Nitro-4-(trifluoromethoxyl)benzoic acid
CAS No.: 784-77-0
Chemical Name: 3-Nitro-4-(trifluoromethoxyl)benzoic acid
Synonyms: 3-Nitro-4-(trifluoromethoxy)benzoic acid;3-Nitro-4-(trifluoromethoxyl)benzoic acid;3-Nitro-4-(trifluoromethoxy)benzoicacid99%;Benzoic acid, 3-nitro-4-(trifluoromethoxy)-;alpha,alpha,alpha-Trifluoro-3-nitro-p-anisic acid
CBNumber: CB32502570
Molecular Formula: C8H4F3NO5
Formula Weight: 251.12
MOL File: 784-77-0.mol

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3-Nitro-4-(trifluoromethoxyl)benzoic acid Property

Boiling point:: 318.9±42.0 °C(Predicted)
Density: 1.628
storage temp.: Sealed in dry,Room Temperature
pka: 3.25±0.10(Predicted)
form: tiny crystalline needles
color: Faint to pale lemon

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Safety

HS Code: 2922498590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: N596985
Product name: 3-Nitro-4-(trifluoromethoxy)benzoicAcid
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 086161
Product name: 3-Nitro-4-(trifluoromethoxy)benzoic acid
Purity: 98%
Packaging: 1g
Price: $19
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4654-3-1Z
Product name: 3-Nitro-4-(trifluoromethoxy)benzoic acid
Purity: 99%
Packaging: 5G
Price: $37
Updated: 2021/12/16

Matrix Scientific

Product number: 086161
Product name: 3-Nitro-4-(trifluoromethoxy)benzoic acid
Purity: 98%
Packaging: 5g
Price: $48
Updated: 2021/12/16

AK Scientific

Product number: Z5131
Product name: 3-Nitro-4-(trifluoromethoxy)benzoicacid
Packaging: 1g
Price: $67
Updated: 2021/12/16

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3-Nitro-4-(trifluoromethoxyl)benzoic acid Chemical Properties,Usage,Production

Chemical Properties

off-white powder

Synthesis

330-12-1

784-77-0

Step 1: Synthesis of 3-nitro-4-(trifluoromethoxy)benzoic acid 4-(Trifluoromethoxy)benzoic acid (900 mg, 4.37 mmol) was dissolved in concentrated hydrochloric acid. Concentrated sulfuric acid (9 mL) was cooled at 0 °C and a concentrated sulfuric acid (4.5 mL) solution of potassium nitrate (486 mg, 4.80 mmol) was slowly added. The reaction temperature was maintained at 0°C with continuous stirring for 2 hours. After completion of the reaction, the mixture was poured into water (50 mL) and extracted with ethyl acetate (150 mL). The organic phase was washed sequentially with brine (2 x 100 mL), dried over anhydrous sodium sulfate, and concentrated to dryness under reduced pressure to afford the crude product 3-nitro-4-(trifluoromethoxy)benzoic acid (1.05 g, 4.18 mmol, 96% yield, MS/ESI+ m/z 252.1 [M+H]+). The crude product can be used directly in the next reaction without further purification.

References

[1] Patent: US2014/155391, 2014, A1. Location in patent: Paragraph 0651; 0652
[2] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 21, p. 5995 - 6006
[3] Patent: US6268387, 2001, B1
[4] Patent: WO2007/31791, 2007, A1. Location in patent: Page/Page column 137
[5] Patent: WO2008/59214, 2008, A1. Location in patent: Page/Page column 147-148

3-Nitro-4-(trifluoromethoxyl)benzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Nitro-4-(trifluoromethoxyl)benzoic acid Suppliers

China 51 India 2 Italy 1 United Kingdom 2 United States 9 Global 65

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View Lastest Price from 3-Nitro-4-(trifluoromethoxyl)benzoic acid manufacturers

Career Henan Chemical Co

Product: 3-Nitro-4-(trifluoromethoxyl)benzoic acid 784-77-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-25

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784-77-0