5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenamine

Product Name: 5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenamine
CAS No.: 116233-17-1
Chemical Name: 5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenamine
Synonyms: 3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-amine;5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenamine;2-Naphthalenamine, 5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-
CBNumber: CB32503254
Molecular Formula: C15H23N
Formula Weight: 217.35
MOL File: 116233-17-1.mol

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5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenamine Property

Melting point:: 96-97 °C
Boiling point:: 321.2±31.0 °C(Predicted)
Density: 0.938±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 5.01±0.60(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

AK Scientific

Product number: Z3596
Product name: 5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenamine
Packaging: 250mg
Price: $172
Updated: 2021/12/16

Ambeed

Product number: A202020
Product name: 3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-amine
Purity: 95+%
Packaging: 1g
Price: $187
Updated: 2021/12/16

Alichem

Product number: 116233171
Product name: 3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-amine
Packaging: 1g
Price: $260.37
Updated: 2021/12/16

Chemenu

Product number: CM141053
Product name: 3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-amine
Purity: 95%
Packaging: 1g
Price: $574
Updated: 2021/12/16

Ambeed

Product number: A202020
Product name: 3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-amine
Purity: 95+%
Packaging: 5g
Price: $742
Updated: 2021/12/16

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5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenamine Chemical Properties,Usage,Production

Synthesis

116233-16-0

116233-17-1

3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-amine (6) was synthesized as follows: 1,1,4,4,6-pentamethyl-7-nitro-1,2,3,4-tetrahydronaphthalene (5) (2.5 g, 10.1 mmol) was dissolved in ethyl acetate (205 mL) to prepare a 0.05 M solution. The hydrogenation reaction was repeated twice using a ThalesNano H-cubereactor at 70°C and 2-5 bar pressure through a 10 mL Pd/C cartridge at a flow rate of 1.0 mL/min. Upon completion of the reaction, the resulting solution was concentrated under vacuum to afford the target product 6 (2.13 g, 97% yield) as a yellow crystalline solid with a melting point of 205°C. The structure of the product was confirmed by the following characterization data: 1H NMR (400 MHz, CDCl3) δ 7.00 (s, 1H), 6.63 (s, 1H), 3.34 (br s, 2H), 2.15 (s, 3H), 1.63 (s, 4H), 1.26 (s, 12H); 13C NMR (100.6 MHz, CDCl3) δ 143.5, 142.0, 135.2, 128.3, 120.5, 112.6, 35.3, 35.2, 33.8, 33.4, 32.0, 31.8, 17.1; IR ( neat)ν 3404, 3335, 2956, 2925, 1626, 1504 cm-1; LC-MS-CI (M+H)+ calculated value C15H24N 218.1909, measured value 218.1908.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 9, p. 2352 - 2356
[2] Patent: WO2015/130973, 2015, A1. Location in patent: Page/Page column 20; 21
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 19, p. 8924 - 8940
[4] Patent: US2018/207156, 2018, A1. Location in patent: Paragraph 0114; 0131
[5] Journal of Medicinal Chemistry, 1989, vol. 32, # 7, p. 1504 - 1517

5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenamine Preparation Products And Raw materials

Raw materials

Preparation Products

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5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenamine Suppliers

China 20 India 1 United States 1 Global 22

JinYan Chemicals(ShangHai) Co.,Ltd.

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Fax: 86-021-50426522,50426273
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Country: China
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Shanghai Synteam Biochem CO.,ltd

Tel: +86-021-58380978 13482386415
Fax: 021-58380978
Email: info@systeambc.com
Country: China
ProdList: 896
Advantage: 50

BePharm Ltd

Tel: 400-685-9117
Fax: 021-51816740
Email: market@bepharm.com
Country: China
ProdList: 15081
Advantage: 60

Xi'an Kaixiang Photoelectric Technology Co., Ltd.

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Country: China
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Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.

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Springchem New Material Technology Co.,Ltd

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Zhengzhou Convergence Chemical Co. LTD

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Energy Chemical

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Beijing Jin Ming Biotechnology Co., Ltd.

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Wuhan Wenjin Chemical Technology Co., Ltd.

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116233-17-1, 5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenamineRelated Search:

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5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenamine

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116233-17-1