6,7-dihydropyrrolo[3,4-b]pyridin-5-one
- Product Name
- 6,7-dihydropyrrolo[3,4-b]pyridin-5-one
- CAS No.
- 40107-93-5
- Chemical Name
- 6,7-dihydropyrrolo[3,4-b]pyridin-5-one
- Synonyms
- 6H,7H-PYRROLO[3,4-B]PYRIDIN-5-ONE;2-(Aminomethyl)nicotinic acid lactam;5H,6H,7H-Pyrrolo[3,4-b]pyridin-5-one;5,7-Dihydropyrrolo[3,4-b]pyridin-5-one;6,7-dihydropyrrolo[3,4-b]pyridin-5-one;6,7-dihydro-5H-pyrrolo[4,3-b]pyridin-5-one;6,7-Dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;6,7-Dihydro-5-oxo-5H-pyrrolo[3,4-b]pyridine;5H-Pyrrolo[3,4-b]pyridin-5-one, 6,7-dihydro-;6,7-dihydropyridine[3,4-B]benzopyridine-5-one
- CBNumber
- CB32506093
- Molecular Formula
- C7H6N2O
- Formula Weight
- 134.14
- MOL File
- 40107-93-5.mol
6,7-dihydropyrrolo[3,4-b]pyridin-5-one Property
- Melting point:
- 204 °C(Solv: ethanol (64-17-5))
- Boiling point:
- 412.1±34.0 °C(Predicted)
- Density
- 1.286±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 12.40±0.20(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933399990
N-Bromosuccinimide Price
- Product number
- CHM0391202
- Product name
- 6,7-DIHYDRO-5H-PYRROLO[3,4-B]PYRIDIN-5-ONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.45
- Updated
- 2021/12/16
- Product number
- 4H48-1-11
- Product name
- 5H,6H,7H-Pyrrolo[3,4-b]pyridin-5-one
- Purity
- 95%
- Packaging
- 250mg
- Price
- $560
- Updated
- 2021/12/16
- Product number
- 5330AB
- Product name
- 6,7-Dihydro-5H-pyrrolo[3,4-b]pyridin-5-one
- Packaging
- 5g
- Price
- $1397
- Updated
- 2021/12/16
- Product number
- CM125197
- Product name
- 6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one
- Purity
- 95%+
- Packaging
- 10g
- Price
- $1493
- Updated
- 2021/12/16
- Product number
- 40107935
- Product name
- 6,7-Dihydro-5H-pyrrolo[3,4-b]pyridin-5-one
- Packaging
- 10g
- Price
- $1580.04
- Updated
- 2021/12/16
6,7-dihydropyrrolo[3,4-b]pyridin-5-one Chemical Properties,Usage,Production
Synthesis
115012-09-4
40107-93-5
General procedure for the synthesis of 6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one from 7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one: To a 7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one (0.32 g, 2.13 mmol, 1.0 equiv) acetic acid ( 8.6 mL) solution was added to zinc powder (0.56 g, 8.50 mmol, 4.0 equiv). The suspension was heated to reflux for 24 hours. Upon completion of the reaction, the mixture was cooled to room temperature and filtered through a diatomaceous earth pad. The filtrate was concentrated under reduced pressure and the residue was dissolved in dichloromethane (CH2Cl2). Anhydrous calcium chloride (CaCl2) was added to this solution and the insoluble material was removed by filtration. The filtrate was concentrated again under reduced pressure and the residue was purified by column chromatography, first using ethyl acetate (EtOAc) as eluent and then switching to a solvent mixture of ethyl acetate/methanol (95:5, v/v) as eluent. The target fraction was collected, concentrated and recrystallized from ethanol (EtOH) to afford 6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one (0.11 g, 38% yield) as a white solid. Melting point: 206°C (decomposition).1H NMR (300 MHz, DMSO-d6) δ 8.66 (br s, 1H), 8.63 (d, J = 4.9 Hz, 1H), 7.95 (d, J = 7.05 Hz, 1H), 7.38 (dd, J = 7.6/4.9 Hz, 1H), 4.3 (s, 2H); 13C NMR (75 MHz, DMSO-d6) δ 168.7, 164.9, 153.0, 131.9, 126.4, 123.6, 47.1; GC-MS m/z 134 (M)+; IR (KBr) 3352, 3199, 1707, 1607, 1411, 1138 cm1. Calculated elemental values (C7H6N2O): C, 62.68; H, 4.3 (s, 2H). Calculated elemental values (C7H6N2O): C, 62.68; H, 4.51; N, 20.88. Measured values: C, 62.73; H, 4.50; N, 20.50.
References
[1] Bulletin of the Chemical Society of Japan, 1987, vol. 60, # 11, p. 4178 - 4180
[2] European Journal of Medicinal Chemistry, 2012, vol. 55, p. 58 - 66,9
[3] Patent: CN105541833, 2016, A. Location in patent: Paragraph 0155; 0156; 0157
6,7-dihydropyrrolo[3,4-b]pyridin-5-one Preparation Products And Raw materials
Raw materials
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View Lastest Price from 6,7-dihydropyrrolo[3,4-b]pyridin-5-one manufacturers
- Product
- 6,7-dihydropyrrolo[3,4-b]pyridin-5-one 40107-93-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-13
- Product
- 6,7-dihydropyrrolo[3,4-b]pyridin-5-one 40107-93-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2019-07-10