ChemicalBook > CAS DataBase List > 4-Amino-3,5-difluorobenzonitrile

4-Amino-3,5-difluorobenzonitrile

Product Name: 4-Amino-3,5-difluorobenzonitrile
CAS No.: 110301-23-0
Chemical Name: 4-Amino-3,5-difluorobenzonitrile
Synonyms: 4-Cyano-2,6-difluoroaniline;4-Amino-3,5-difluorobenzonitrile;Benzonitrile, 4-amino-3,5-difluoro-
CBNumber: CB32506220
Molecular Formula: C7H4F2N2
Formula Weight: 154.12
MOL File: 110301-23-0.mol

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4-Amino-3,5-difluorobenzonitrile Property

Melting point:: 110-111℃
Boiling point:: 235.5±40.0 °C(Predicted)
Density: 1.36±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: solid
pka: -1.07±0.10(Predicted)
color: Grey to purple

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Safety

HS Code: 2926907090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Apolloscientific

Product number: PC5545
Product name: 4-Amino-3,5-difluorobenzonitrile
Packaging: 1g
Price: $48
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3637-3-Y3
Product name: 4-Amino-3,5-difluorobenzonitrile
Packaging: 1g
Price: $56
Updated: 2021/12/16

AK Scientific

Product number: J97076
Product name: 4-Amino-3,5-difluorobenzonitrile
Packaging: 10g
Price: $210
Updated: 2021/12/16

Matrix Scientific

Product number: 075825
Product name: 4-Amino-3,5-difluorobenzonitrile
Purity: 95+%
Packaging: 1g
Price: $331
Updated: 2021/12/16

AK Scientific

Product number: J97076
Product name: 4-Amino-3,5-difluorobenzonitrile
Packaging: 5g
Price: $140
Updated: 2021/12/16

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4-Amino-3,5-difluorobenzonitrile Chemical Properties,Usage,Production

Uses

4-Amino-3,5-difluorobenzonitrile can be used to prepare tricyclic AKR1C3 dependent KARS inhibitors to treat diseases and disorders mediated by an AKR1C3 dependent KARS inhibitor.

Synthesis

141743-49-9

544-92-3

110301-23-0

General procedure for the synthesis of 4-amino-3,5-difluorobenzonitrile from 2,6-difluoro-4-iodoaniline and cuprous cyanide: a mixture of 2,6-difluoro-4-iodoaniline and cuprous cyanide in N,N-dimethylformamide (DMF) was heated and refluxed for 48 hours. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad to remove insoluble impurities. The filtrate was transferred to a partition funnel and partitioned by adding dichloromethane and water. The extraction of the aqueous phase was repeated twice with dichloromethane. All organic phases were combined and washed with saturated brine and subsequently dried over anhydrous sodium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure to give the crude product. The crude product was purified by column chromatography using hexane/ethyl acetate (4:1, v/v) as eluent, resulting in the target product 4-amino-3,5-difluorobenzonitrile (1.03 g, 66% yield) in yellow solid form. The product was characterized by 1H NMR (300 MHz, CDCl3): δ 7.15 (dd, 2H, J = 2.4, 6.0 Hz), 4.28 (br s, 2H).

References

[1] Patent: WO2006/98554, 2006, A1. Location in patent: Page/Page column 78

4-Amino-3,5-difluorobenzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Amino-3,5-difluorobenzonitrile manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-Amino-3,5-difluorobenzonitrile 110301-23-0
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-06

Henan Bao Enluo International TradeCo.，LTD

Product: 4-Amino-3,5-difluorobenzonitrile 110301-23-0
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 10000MT
Release date: 2023-08-10

Career Henan Chemical Co

Product: 4-Amino-3,5-difluorobenzonitrile 110301-23-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-11

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110301-23-0