Y-39983 hydrochloride

Product Name: Y-39983 hydrochloride
CAS No.: 471843-75-1
Chemical Name: Y-39983 hydrochloride
Synonyms: Y 39983;Y-39983 HCI;Y 39983, (HCl);(594859-54-8) y 39983;Y-33075 (hydrochloride);4-[(1R)-1-Aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide hydrochloride;(R)-4-(1-Aminoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzamide hydrochloride;4-[(1R)-1-Aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide hydrochloride ISO 9001：2015 REACH
CBNumber: CB32509933
Molecular Formula: C16H16N4O.HCl
Formula Weight: 316.78538
MOL File: 471843-75-1.mol

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Y-39983 hydrochloride Property

storage temp.: -20°C
solubility: DMSO: soluble
form: A solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0014196
Product name: Y-39983
Purity: 95.00%
Packaging: 5MG
Price: $502.87
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611891
Product name: Y-39983
Purity: >98%
Packaging: 50mg
Price: $765
Updated: 2021/12/16

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Y-39983 hydrochloride Chemical Properties,Usage,Production

Description

Y-39983 hydrochloride, also known as Y-33075, is a selective Rho-associated coiled coil-forming protein kinase (ROCK) inhibitor derived from Y-27632, and is more potent than Y-27632, with an IC50 of 3.6 nM.

in vitro

In rabbits, topical administration of Y-39983 significantly increased conventional outflow by 65.5%, followed by significant, dose-dependent reduction in IOP. Maximum IOP reduction was 13.2 ± 0.6 mm Hg (mean ± SE) at 0.1% Y-39983 in rabbits. In monkeys, at 3 hours after topical administration of 0.05% Y-39983, maximum reduction of IOP was 2.5 ± 0.8 mm Hg. No serious side effects were observed in ocular tissues except sporadic punctate subconjunctival hemorrhage during long-term topical administration of Y-39983 four times a day (at 2-hour intervals) in rabbits or monkeys. However, punctate subconjunctival hemorrhage was not observed with administration twice daily (at a 6-hour interval) or three times a day (at 5-hour intervals).

References

[1]. Hideki Tokushige, et al. Effects of Topical Administration of Y-39983, a Selective Rho-Associated Protein Kinase Inhibitor, on Ocular Tissues in Rabbits and Monkeys Invest. Ophthalmol. Vis. Sci. July 2007 vol. 48no. 7 3216-3222 DOI:10.1167/IOVS.05-1617
[2]. Tokushige H, et al. Effects of Y-39983, a selective Rho-associated protein kinase inhibitor, on blood flow in optic nerve head in rabbits and axonal regeneration of retinal ganglion cells in rats. Curr Eye Res. 2011 Oct;36(10):964-70. DOI:10.3109/02713683.2011.599106
[3]. Watabe H, et al. Effects of Rho-associated protein kinase inhibitors Y-27632 and Y-39983 on isolated rabbit ciliary arteries.Jpn J Ophthalmol. 2011 Jul;55(4):411-7. Epub 2011 Jun 11. DOI:10.1007/s10384-011-0048-9

Y-39983 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Y-39983 hydrochloride Suppliers

China 14 United States 2 Global 16

ShangHai Caerulum Pharma Discovery Co., Ltd.

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DC Chemicals

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View Lastest Price from Y-39983 hydrochloride manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4-[(1R)-1-Aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide hydrochloride 471843-75-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-12

471843-75-1, Y-39983 hydrochlorideRelated Search:

Y 39983

4-[(1R)-1-Aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide hydrochloride

Y 39983, (HCl)

(594859-54-8) y 39983

4-[(1R)-1-Aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide hydrochloride ISO 9001：2015 REACH

Y-39983 HCI

(R)-4-(1-Aminoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzamide hydrochloride

Y-33075 (hydrochloride)

471843-75-1

C16H16N4OHCl

C16H16N4OClH