2-Formylthiophene-4-boronic acid pinacol ester
- Product Name
- 2-Formylthiophene-4-boronic acid pinacol ester
- CAS No.
- 881381-12-0
- Chemical Name
- 2-Formylthiophene-4-boronic acid pinacol ester
- Synonyms
- 2-Formylthiophene-4-boronic acid pinacol ester;4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carbaldehyde;4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carbaldehyde;3-hydroxy-2,3-dimethylbutan-2-yl hydrogen (5-formylthiophen-3-yl)boronate;4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-Thiophenecarboxaldehyde;2-Thiophenecarboxaldehyde, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
- CBNumber
- CB32510094
- Molecular Formula
- C11H15BO3S
- Formula Weight
- 238.11
- MOL File
- 881381-12-0.mol
2-Formylthiophene-4-boronic acid pinacol ester Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- Appearance
- White to light brown Solid
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- T889618
- Product name
- 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carbaldehyde
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- BOR0004466
- Product name
- 2-FORMYLTHIOPHENE-4-BORONIC ACID PINACOL ESTER
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $179.55
- Updated
- 2021/12/16
- Product number
- 089974
- Product name
- 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carbaldehyde
- Purity
- 95+%
- Packaging
- 1g
- Price
- $227
- Updated
- 2021/12/16
- Product number
- 6H66-1-43
- Product name
- 4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carbaldehyde
- Packaging
- 5G
- Price
- $365
- Updated
- 2021/12/16
- Product number
- AMTB826
- Product name
- 2-Formylthiophene-4-boronicacidpinacolester
- Packaging
- 25g
- Price
- $506
- Updated
- 2021/12/16
2-Formylthiophene-4-boronic acid pinacol ester Chemical Properties,Usage,Production
Synthesis
18791-75-8
73183-34-3
881381-12-0
General procedure for the synthesis of 2-formylthiophene-4-boronic acid pinacol ester from 4-bromo-2-thiophenecarboxaldehyde and bis(pinacolato)diboron (865 mg, 3.403 mmol), potassium acetate (667 mg, 6.81 mmol) and PdCl2(dppf) (96 mg, 0.131 mmol). The reaction mixture was placed in a microwave reactor and heated at 150 °C for 20 min. After completion of the reaction, all solvents were removed by evaporation. The residue was partitioned between ethyl acetate (100 mL) and water (100 mL). The aqueous layer was extracted with ethyl acetate (2 x 100 mL). The combined organic phases were washed with brine (100 mL), dried over anhydrous MgSO4 and concentrated. The crude product was purified by Combiflash fast column (elution gradient: hexane/ethyl acetate, 1%-30% ethyl acetate, 20 min) to afford pinacol ester of 2-formylthiophene-4-boronic acid (550 mg, 88% yield).LC/MS analysis: m/z 238.2 ([M+H]+), retention time 1.88 min.
References
[1] Patent: WO2006/34317, 2006, A2. Location in patent: Page/Page column 94
[2] Patent: WO2008/118724, 2008, A1. Location in patent: Page/Page column 148-149
2-Formylthiophene-4-boronic acid pinacol ester Preparation Products And Raw materials
Raw materials
Preparation Products
2-Formylthiophene-4-boronic acid pinacol ester Suppliers
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- info@chemsworth.com
- Country
- India
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- 6700
- Advantage
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View Lastest Price from 2-Formylthiophene-4-boronic acid pinacol ester manufacturers
- Product
- 2-Formylthiophene-4-boronic acid pinacol ester 881381-12-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-02