ChemicalBook > CAS DataBase List > Tolbutamide-d9

Tolbutamide-d9

Product Name
Tolbutamide-d9
CAS No.
1219794-57-6
Chemical Name
Tolbutamide-d9
Synonyms
Mobenol-d9;Artozin-d9;Artosin-d9;[2H9]-Tolbutamide;Tolylsulfonylbutylurea-d9;Tolbutamide-d9 Solution, 100ppm;3-(p-Tolyl-4-sulfonyl)-1-butylurea-d9;1-(Butyl-3-(p-tolyl- sulfonyl)urea-d9;N-Butyl-N'-(4-Methylphenylsulfonyl)urea-d9;N-[(ButylaMino-d9)carbonyl]-4-MethylbenzenesulfonaMide
CBNumber
CB32512331
Molecular Formula
C12H18N2O3S
Formula Weight
270.35
MOL File
1219794-57-6.mol
More
Less

Tolbutamide-d9 Property

Melting point:
108-111°C
storage temp. 
Refrigerator
solubility 
DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:1): 0.14 mg/ml
form 
A solid
color 
White to off-white
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
30738
Product name
Tolbutamide-d9
Packaging
1mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
30738
Product name
Tolbutamide-d9
Packaging
10mg
Price
$575
Updated
2024/03/01
Cayman Chemical
Product number
30738
Product name
Tolbutamide-d9
Packaging
5mg
Price
$324
Updated
2024/03/01
TRC
Product number
T535152
Product name
Tolbutamide-d9
Packaging
25mg
Price
$1355
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
D2584
Product name
Tolbutamide-d9(butyl-d9)
Packaging
0.05g
Price
$1700
Updated
2021/12/16
More
Less

Tolbutamide-d9 Chemical Properties,Usage,Production

Description

Tolbutamide-d9 is intended for use as an internal standard for the quantification of tolbutamide by GC- or LC-MS. Tolbutamide is an inhibitor of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (IC50 = 4.9 μM). It is selective for SUR1/Kir6.2 over SUR2A/Kir6.2 and SUR2B/Kir6.2 channels (IC50s = 85 and 88 μM, respectively). Tolbutamide increases glucose-induced insulin secretion and calcium influx in isolated mouse pancreatic islets. In vivo, tolbutamide (80 mg/kg) reduces blood glucose levels in a mouse model of diabetes induced by streptozotocin (STZ; ). Formulations containing tolbutamide have been used in the treatment of type 2 diabetes.

Chemical Properties

White Solid

Uses

Labelled Tolbutamide (T535150). An antidiabetic, used as a hypoglycemic agent in veterinary medicine.

References

[1] PETER PROKS. Sulfonylurea stimulation of insulin secretion.[J]. Diabetes, 2002, 51 Suppl 3: S368-76. DOI: 10.2337/diabetes.51.2007.s368
[2] NOBUYOSHI ISHIYAMA  Jean C H  Magalie A Ravier. Dual mechanism of the potentiation by glucose of insulin secretion induced by arginine and tolbutamide in mouse islets.[J]. American journal of physiology. Endocrinology and metabolism, 2006, 290 3: E540-9. DOI: 10.1152/ajpendo.00032.2005
[3] CLAUS RERUP  Finn T. Streptozotocin- and alloxan-diabetes in mice[J]. European journal of pharmacology, 1969, 7 1: Pages 89-96. DOI: 10.1016/0014-2999(69)90169-1

Tolbutamide-d9 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Tolbutamide-d9 Suppliers

Canada 2 China 21 India 2 United States 1 Global 26
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Alta Scientific Co., Ltd.
Tel
022-6537-8550 15522853686
Fax
022-2532-9655
Email
sales@altasci.com.cn
Country
China
ProdList
4511
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Nanjing Haolv Biotechnology Co.,Ltd
Tel
025-84622273 17361806303
Email
kexin.zhou@haolvbiotech.com
Country
China
ProdList
3019
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57422
Advantage
58
Hubei Jusheng Technology Co.,Ltd.
Tel
18871490254
Fax
027-59599243
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
28172
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44894
Advantage
58
ChengDu SinoStandards Bio-Tech Co.,Ltd. ，
Tel
028-83243028 19136088901
Email
sinostandards@163.com
Country
China
ProdList
4976
Advantage
58
Yancheng Tongming Biotechnology Co., Ltd.
Tel
15195160625
Email
2863565288@qq.com
Country
China
ProdList
5192
Advantage
58
ChemeGen
Tel
18818260767
Fax
QQ 3610331285
Email
2625930290@qq.com
Country
China
ProdList
6973
Advantage
58
LGC Science (Shanghai) Ltd.
Tel
17717235263
Email
cindy.yang@lgcgroup.com
Country
China
ProdList
18003
Advantage
58
Shanghai isotope chemical co.,ltd
Tel
021-51600108 13062666369
Email
sales@isotopechem.com
Country
China
ProdList
5000
Advantage
58
Cayman Chemical Company
Tel
800-364-9897
Email
sales@caymanchem.com
Country
China
ProdList
6838
Advantage
58
Santa Cruz Biotechnology Inc
Tel
021-60936350
Email
scbt@scbt.com
Country
China
ProdList
6594
Advantage
58
Guangzhou Chuangze Biotechnology Co., Ltd.
Tel
18312220236
Country
CHINA
ProdList
178
Advantage
58
Foshan Minghua Biotechnology Co., Ltd.
Tel
18312287787
Country
CHINA
ProdList
196
Advantage
58
Guangzhou Weisheng Biotechnology Co., Ltd.
Tel
17765667235
Country
CHINA
ProdList
129
Advantage
58
Shanghai Xiyuan Biotechnology Co., Ltd
Tel
--
Fax
--
Email
shxiyuanbio@163.com
Country
CHINA
ProdList
6934
Advantage
58
Absin Bioscience Inc.
Tel
--
Fax
--
Email
chenjw@absin.cn
Country
CHINA
ProdList
6208
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58

1219794-57-6, Tolbutamide-d9Related Search:

TOLAZAMIDE Tolbutamide Impurity 5 4-Carboxytolbutamide Methyl Ester TOLBUTAMIDE Tolbutamide 4-Carboxy Ethyl Ester 4-Hydroxytolbutamide

  • 1-(Butyl-3-(p-tolyl- sulfonyl)urea-d9
  • 3-(p-Tolyl-4-sulfonyl)-1-butylurea-d9
  • Artosin-d9
  • Artozin-d9
  • Mobenol-d9
  • N-[(ButylaMino-d9)carbonyl]-4-MethylbenzenesulfonaMide
  • N-Butyl-N'-(4-Methylphenylsulfonyl)urea-d9
  • Tolylsulfonylbutylurea-d9
  • 1-(4-methylphenyl)sulfonyl-3-(1,1,2,2,3,3,4,4,4-nonadeuteriobutyl)urea
  • Tolbutamide-d9 Solution, 100ppm
  • [2H9]-Tolbutamide
  • N-[(butyl-1,1,2,2,3,3,4,4,4-d9-amino)carbonyl]-4-methyl-benzenesulfonamide
  • 1219794-57-6
  • C12H9D9N2O3S
  • Aromatics
  • Intermediates & Fine Chemicals
  • Isotope Labelled Compounds
  • Pharmaceuticals
  • Sulfur & Selenium Compounds