ChemicalBook > CAS DataBase List > 5-bromopyridazin-4-amine

5-bromopyridazin-4-amine

Product Name: 5-bromopyridazin-4-amine
CAS No.: 55928-90-0
Chemical Name: 5-bromopyridazin-4-amine
Synonyms: 5-Bromo-4-pyridazinamine;5-bromopyridazin-4-amine;4-Amino-5-bromopyridazine;5-bromopyridazin-4-aminev;4-Pyridazinamine, 5-bromo-
CBNumber: CB32514092
Molecular Formula: C4H4BrN3
Formula Weight: 174
MOL File: 55928-90-0.mol

Less

5-bromopyridazin-4-amine Property

Boiling point:: 354.9±22.0 °C(Predicted)
Density: 1.844±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 4.50±0.10(Predicted)
Appearance: Yellow to brown Solid
InChI: InChI=1S/C4H4BrN3/c5-3-1-7-8-2-4(3)6/h1-2H,(H2,6,7)
InChIKey: KYXLLQKHVRNCCS-UHFFFAOYSA-N
SMILES: C1=NN=CC(Br)=C1N

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

TRC

Product number: B122460
Product name: 5-Bromo-4-pyridazinamine
Packaging: 50mg
Price: $110
Updated: 2021/12/16

TRC

Product number: B122460
Product name: 5-Bromo-4-pyridazinamine
Packaging: 25mg
Price: $70
Updated: 2021/12/16

AK Scientific

Product number: Y3269
Product name: 5-Bromopyridazin-4-amine
Packaging: 100mg
Price: $108
Updated: 2021/12/16

Matrix Scientific

Product number: 145557
Product name: 5-Bromopyridazin-4-amine
Purity: 95%
Packaging: 1g
Price: $1421
Updated: 2021/12/16

Matrix Scientific

Product number: 145557
Product name: 5-Bromopyridazin-4-amine
Purity: 95%
Packaging: 250mg
Price: $570
Updated: 2021/12/16

Less

5-bromopyridazin-4-amine Chemical Properties,Usage,Production

Uses

5-?Bromo-?4-?pyridazinamine is a reactant used in the preparation of glucocortocoid receptor agonists with potential for reduced clinical bone side effects.

Synthesis

20744-39-2

55928-90-0

General procedure for the synthesis of 5-bromo-4-pyrazinamine from 4-aminopyridazine: pyridazin-4-amine (1.18 g, 12.41 mmol) was dissolved in acetic acid (2.5 mL) in a water bath at room temperature. Dibromide (0.638 mL, 12.41 mmol) was added slowly and dropwise. After 1 hour of reaction, the reaction was neutralized by the addition of 10N NaOH solution, followed by extraction with dichloromethane (3 times). The organic phases were combined, dried over sodium sulfate and subsequently concentrated under vacuum. The crude product was dissolved in a small amount of dichloromethane and purified by passing through a 40 g silica gel column using a 0-15% dichloromethane/methanol gradient elution for 40 min. Fractions containing the target product were collected and combined and dried under vacuum to give 3-bromopyridazin-4-amine (0.1 g, 0.575 mmol, 4.63% yield, first elution) and 5-bromopyridazin-4-amine (0.12 g, 0.690 mmol, 5.56% yield, second elution), respectively. The 1H NMR (400 MHz, DMSO-d6) data of the product 5-bromopyridazin-4-amine were as follows: δ 8.75 (s, 1H), 8.55 (s, 1H), 6.72-6.79 (m, 2H).

References

[1] Patent: WO2015/69594, 2015, A1. Location in patent: Page/Page column 196
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 4, p. 1583 - 1598

5-bromopyridazin-4-amine Preparation Products And Raw materials

Raw materials

Preparation Products

Less

5-bromopyridazin-4-amine Suppliers

China 48 India 1 United States 4 Global 53

Zhengzhou HSH Science & Technology Co., Ltd.

Tel: 0371-55932928 18937192232
Fax: 0086-0371-55932928
Email: 1282296214@qq.com
Country: China
ProdList: 498
Advantage: 55

Shanghai Shen Zhen Pharm Chemical Co., Ltd.

Tel: 13564376153
Email: sell.shsz@outlook.com
Country: China
ProdList: 239
Advantage: 58

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9309
Advantage: 66

Tetranov Biopharm

Tel: 13526569071
Email: sales@leadmedpharm.com
Country: China
ProdList: 7892
Advantage: 64

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Wuhan Kaymke Chemical Co., Ltd.,

Tel: 027-027-87342388 18086026008
Fax: 027-87342388
Email: sales@kaymke.com
Country: China
ProdList: 3731
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9125
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shanghai Rlavie Technology Co., Ltd.

Tel: 21-67759270 17717059219
Fax: QQ：1479352695
Email: sales@rlavie.com
Country: China
ProdList: 1620
Advantage: 55

Biokitchen

Tel: 021-021-021-31663258 13795219287
Fax: 021-31663258
Email: donghuanwen@126.com
Country: China
ProdList: 8816
Advantage: 58

Aikon International Limited

Tel: 025-66061636 18013972705
Fax: (3)02557626880
Email: qqyang@aikonchem.com
Country: China
ProdList: 15814
Advantage: 58

Yujinpharma(Tianjin) Technology Co.,Ltd.

Tel: 13370351217 kungfu1217@1
Fax: QQ1400885609
Email: kungfu1217@163.com
Country: China
ProdList: 2720
Advantage: 58

Cool Pharm, Ltd

Tel: 021-58581007 18019463053
Fax: 021-50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12878
Advantage: 58

ROSEWA HOLDING GROUP CO.,LIMITED

Tel: +86-023-62871537
Email: sales@rosewachem.com
Country: China
ProdList: 2803
Advantage: 58

Chengdu Feibai Pharmaceutical Co., Ltd.

Tel: 028-84641798 18782128315
Email: 3302391190@qq.com
Country: China
ProdList: 9800
Advantage: 55

Labnetwork lnc.

Tel: +86-27-50766799 +8618062016861
Email: contact@labnetwork.com
Country: China
ProdList: 19987
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30229
Advantage: 58

Shanghai Lanle Bird Industrial Co., Ltd.

Tel: 15021845385
Email: 765325601@qq.com
Country: China
ProdList: 3609
Advantage: 58

Xi'an Minze Pharmaceutical Technology Co., Ltd

Tel: 13981836672
Email: 2560370848@qq.com
Country: China
ProdList: 2807
Advantage: 58

LEADMEDPHARM CO.,LTD

Tel: 13674959855 13674959855
Email: sales@synthontech.com
Country: China
ProdList: 3035
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49975
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-29-87569266 +86-17392581500
Fax: 029-88380327
Email: 1015@dideu.com
Country: China
ProdList: 3987
Advantage: 58

Shanghai Yihua Chemical Co., Ltd.

Tel: 021-6785342
Fax: QQ:2771325243 Inquiry
Email: 2771325243@qq.com
Country: China
ProdList: 271
Advantage: 58

Birdo (Shanghai) Medical Technology Co., Ltd.

Tel: 021-58099077-8041 18601625411
Email: sales@birdotech.com
Country: China
ProdList: 9764
Advantage: 58

Taizhou Nanfeng Pharmaceutical Research Institute

Tel: nanfengdrug@163.com; 18616377689
Email: nanfengdrug@163.com
Country: China
ProdList: 20009
Advantage: 58

Henan Weitesi Chemical Technology Co. LTD

Tel: 0371-0371-55135753 18003832934
Fax: QQ：2853979818
Email: 2853979818@qq.com
Country: China
ProdList: 9991
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44119
Advantage: 58

Ningbo jinuo chemical co., LTD

Tel: 0574-87314919 057487319282
Email: info@nbinno.com
Country: China
ProdList: 7047
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40000
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-6005915
Email: sales@picasso-e.com
Country: China
ProdList: 39665
Advantage: 58

Yutong Pharmaceutical Technology (Suzhou) Co., Ltd.

Tel: 0512-15851462628 15851462628
Email: 2680463261@qq.com
Country: China
ProdList: 4996
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 17801761073
Email: Gsiyu@solarbio.com
Country: China
ProdList: 50464
Advantage: 58

Shanghai Jieshikai Biotechnology Co. , Ltd.

Tel: 021-57520305 13795461237
Email: zhuruyan@jskchem.com
Country: China
ProdList: 49234
Advantage: 58

https://hanhongsci.com/

Tel: 021-54306202 18917919676
Email: info@hanhongsci.com
Country: China
ProdList: 29995
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: 400-6206333 13167063860
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 48457
Advantage: 58

Beijing Born Pharmaceutical Co., Ltd.

Tel: 13261021908
Email: 1198872622@qq.com
Country: China
ProdList: 909
Advantage: 55

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

Yangzhou Haihao Biotechnology Co.,Ltd

Tel: 0514-15895751441 15895751441
Email: 3940147892@qq.com
Country: China
ProdList: 1272
Advantage: 58

Shanghai Yaoheping Biopharmaceutical Technology Co., Ltd

Tel: 021-57540919 13120888836
Email: lily@yhp-biomedicine.com
Country: China
ProdList: 8256
Advantage: 58

SUZHOU SENFEIDA CHEMICAL CO.,LTD

Tel: +86-0512-83500002 +8618662433356
Email: 3899766280@qq.com
Country: China
ProdList: 26362
Advantage: 58

Shenzhen Zuoke Biotechnology Co., Ltd.

Tel: 13532174601
Country: CHINA
ProdList: 109
Advantage: 58

Beijing Boning Biotechnology Co., Ltd.

Tel: 13269979963
Email: 1565439254@qq.com
Country: CHINA
ProdList: 195
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Shanghai Machine Pure Industrial Co., Ltd.

Tel: --
Fax: --
Email: 3245176082@qq.com
Country: CHINA
ProdList: 6800
Advantage: 58

Shanghai Wowu Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: shhebio@126.com
Country: CHINA
ProdList: 6137
Advantage: 58

55928-90-0, 5-bromopyridazin-4-amineRelated Search:

5-bromopyridazin-4-amine

5-bromopyridazin-4-aminev

4-Pyridazinamine, 5-bromo-

5-Bromo-4-pyridazinamine

4-Amino-5-bromopyridazine

55928-90-0