Daclatasvir Dihydrochloride

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Daclatasvir Dihydrochloride

Product Name: Daclatasvir Dihydrochloride
CAS No.: 1009119-65-6
Chemical Name: Daclatasvir Dihydrochloride
Synonyms: BMS 790052;Declatasvir;BMS790052 HCl;Daclatasvir API;BMS-790052 2HCl;Daclatasvir HCL;Daclatasvir DiHCl;DACLATASVIR(2HCl);Daclatasvir/Daklinza;BMS 790052 (di HClsalt)
CBNumber: CB32514542
Molecular Formula: C40H51ClN8O6
Formula Weight: 775.35
MOL File: 1009119-65-6.mol

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Daclatasvir Dihydrochloride Property

Melting point:: >207°C (dec.)
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form: Solid
color: Off-White to Yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P314Get medical advice/attention if you feel unwell.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: D101505
Product name: DaclatasvirDihydrochloride
Packaging: 100mg
Price: $1320
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb181228
Product name: Daclatasvir dihydrochloride (BMS-790052)
Purity: >99%
Packaging: 1g
Price: $1208.7
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb181228
Product name: Daclatasvir dihydrochloride (BMS-790052)
Purity: >99%
Packaging: 100mg
Price: $414.8
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb181228
Product name: Daclatasvir dihydrochloride (BMS-790052)
Purity: >99%
Packaging: 250mg
Price: $615.4
Updated: 2021/12/16

ChemScene

Product number: CS-0270
Product name: Daclatasvir(dihydrochloride)
Purity: 99.62%
Packaging: 5mg
Price: $50
Updated: 2021/12/16

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Daclatasvir Dihydrochloride Chemical Properties,Usage,Production

Description

Daclatasvir dihydrochloride is a hepatitis C virus nonstructural 5A (NS5A) replication complex inhibitor which was first approved in Japan for the treatment of genotype 1 HCV patients who fail to respond to interferon plus ribavirin. The drug has also been approved for patients with untreated, chronic HCV who are eligible for interferon. Additionally, in Europe, daclatasvir was approved for use in combination with other products across genotype 1–4 HCV. Daclatasvir was discovered and developed by Bristol–Myers Squibb and a fascinating account describing the initiation of the program from a phenotypic screen and the medicinal chemistry strategy leading to the discovery of the compound has been recently reported.

Chemical Properties

Daclatasvir dihydrochloride is white to yellow powder. It is freely soluble in water (>700 mg/mL). The solubility is strongly pH-dependent and the solubility is high at low pH values.

Uses

Daclatasvir Dihydrochloride is the dihydrochloride salt form of daclatasvir, an orally available inhibitor of the hepatitis C virus (HCV) non-structural protein 5A (NS5A) replication complex, with potential activity against HCV. Daclatasvir is used with another antiviral medication (sofosbuvir) to treat chronic (long-lasting) hepatitis C, a viral infection of the liver. Daclatasvir should never be used without sofosbuvir. Daclatasvir and sofosbuvir may also be used with another antiviral medication (ribavirin).

Definition

ChEBI: Daclatasvir hydrochloride is a hydrochloride obtained by combining daclatasvir with two molar equivalents of hydrochloric acid. It is a potent inhibitor of nonstructural protein 5A and is used for treatment of hepatitis C. It has a role as an antiviral drug and a nonstructural protein 5A inhibitor. It contains a daclatasvir(2+).

Synthesis

Bromination of commercial 4,40-diacetylbiphenyl (58) gave 4,40-bis(bromoacetyl)biphenyl 59 in 82% yield. Alkylation of NBoc- L-proline (60) with 59 gave diester 61 which was treated with ammonium acetate to effect cyclization of the bis-ketoester to provide bis-imidazole 62 in 63% yield for the two steps. Acidic removal of the Boc protecting groups followed by recrystallization provided bis-pyrrolidine 63 in high yield. Acylation of 63 with N-(methoxycarbonyl)- L-valine (64) using N-(3-dimethylaminopropyl)-N0-ethylcarbodiimide (EDC) and 1-hydroxybenxotriazole hydrate (HOBT) provided declatasvir. The dihydrochloride salt was prepared and treated with Cuno Zet Carbon ® followed by crystallization from acetone to give daclatasvir dihydrochloride (IX) in 74% yield.

Mode of action

Daclatasvir is an inhibitor of nonstructural protein 5A (NS5A), a multifunctional protein that is an essential component of the HCV replication complex. Daclatasvir binds to the N-terminus of NS5A and inhibits both viral RNA replication and virion assembly.

Daclatasvir Dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Daclatasvir Dihydrochloride manufacturers

Sinoway Industrial co., ltd.

Product: Daclatasvir 1009119-65-6
Price: US $0.00/Kg/Bag
Min. Order: 2Kg/Bag
Purity: 99% up, High Density
Supply Ability: 20 tons
Release date: 2022-07-19

Hangzhou Huarong Pharm Co., Ltd.

Product: Daclatasvir Dihydrochloride 1009119-65-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KG
Release date: 2021-09-15

Dideu Industries Group Limited

Product: N,N'-[[1,1'-Biphenyl]-4,4'-diylbis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]biscarbamic acid dimethyl ester hydrochloride 1009119-65-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-08-18

1009119-65-6, Daclatasvir DihydrochlorideRelated Search:

Daclatasvir tadalafi methyl ((S)-1-((S)-2-(5-(4'-(2-((S)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-yl)-1H-imidazol-4-yl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate Daclatasvir Impurity 5 (SRSS-Isomer) Daclatasvir Impurity F Daclatasvir Impurity 1-{4'-acetyl-[1,1'-biphenyl]-4-yl}-2-bromoethan-1-one Daclatasvir Impurity 7 1,1'-[1,1'-biphenyl]-4,4'-diylbis[2,2-dibromo]-ethanone

BMS 790052

N,N'-[[1,1'-Biphenyl]-4,4'-diylbis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]biscarbamic acid dimethyl ester hydrochloride

BMS-790052;BMS790052 ;BMS 790052;DACLATASVIR;BMS-790052 DIHYDROCHLORIDE;BMS790052 DIHYDROCHLORIDE;BMS 790052 DIHYDROCHLORIDE

BMS-790052; BMS790052 ; BMS 790052;DACLATASVIR

Daclatasvir dihydrochloride (BMS-790052)

BMS 790052 (di HClsalt)

N,N'-[[1,1'-Biphenyl]-4,4'-diylbis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-

Daclatasvir dihydrochloride (BMS-790052 dihydrochloride)

Dacatavir dihydrochloride

Daclatavir Dihydrochloride

Daclatasvir DiHCl

Daclatasvir`Daclatasvir dihydrochloride

Dclatasvir dihydrochloride

Daclatasvir Digydrochloride

Carbamic acid, N,N'-[[1,1'-biphenyl]-4,4'-diylbis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]bis-, C,C'-dimethyl ester, hydrochloride (1:2)

Daclatasvir API

Dackatasvir dihydrochloride

daclatasvir hydrochloride

BMS-790052 (dihydrochloride)

BMS790052 HCl

Daclatasvir dihydrochloride

BMS-790052 2HCl

DACLATASVIR(2HCl)

Daclatasvir HCL

Methyl (1-((2S)-2-(5-(4'-(2-(1-((methoxycarbonyl)valyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate hydrochloride

Daclatasivir Dihydrochloride

Daclatasvir/Daklinza

dimethyl ((2S,2'S)-((2S,2'S)-2,2'-(5,5'-([1,1'-biphenyl]-4,4'-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl))dicarbamate

Daclatasvir dihydrochloride, >=98%

N,N'-[[1,1'-Biphenyl]-4,4'-diylbis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]biscarbamic acid dimethyl ester hydrochloride USP/EP/BP

Daclatasvir dihydrochlorid

methyl N-[(2S)-1-[(2S)-2-[5-(4'-{2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl}-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate dihydrochloride

TIANFU CHEM---N,N'-[[1,1'-Biphenyl]-4,4'-diylbis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]biscarbamic acid dimethyl ester hydrochloride

Daclatasvir dihydrochloride(BMS-790052) Competitive price/Top quality

Methyl ((S)-1-((S)-2-(5-(4'-(2-((S)-1-((methoxycarbonyl)-L-valyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate dihydrochloride

Declatasvir

Daclatasvir Hcl In-House

methyl N-[(2S)-1-[(2S)-2-{4-[4-(4-{2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate.dihydrochloride

N,N'-[[1,1'-Biphenyl]-4,4'-diylbis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]biscarbamic acid dimethyl ester hydrochloride

1009119-65-6

C40H52Cl2N8O6

C40H50N8O62HCl

C40H50N8O62ClH

Inhibitors