4-bromo-1-tert-butyl-1H-pyrazole
- Product Name
- 4-bromo-1-tert-butyl-1H-pyrazole
- CAS No.
- 70951-85-8
- Chemical Name
- 4-bromo-1-tert-butyl-1H-pyrazole
- Synonyms
- 4-Bromo-1-t-butylpyrazole;4-Bromo-1-tert-butylpyrazole;1-tert-Butyl-4-Bromopyrazole;4-bromo-1-t-butyl-1H-pyrazole;4-bromo-1-tert-butyl-1H-pyrazole;1H-Pyrazole, 4-bromo-1-(1,1-dimethylethyl)-
- CBNumber
- CB32515695
- Molecular Formula
- C7H11BrN2
- Formula Weight
- 203.08
- MOL File
- 70951-85-8.mol
4-bromo-1-tert-butyl-1H-pyrazole Property
- Boiling point:
- 229.8±13.0℃ (760 Torr)
- Density
- 1.37±0.1 g/cm3 (20 ºC 760 Torr)
- Flash point:
- 92.8±19.8℃
- storage temp.
- 2-8°C
- Appearance
- Colorless to light yellow Liquid
- InChI
- InChI=1S/C7H11BrN2/c1-7(2,3)10-5-6(8)4-9-10/h4-5H,1-3H3
- InChIKey
- KLLXOOSSATXFFY-UHFFFAOYSA-N
- SMILES
- N1(C(C)(C)C)C=C(Br)C=N1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B680178
- Product name
- 4-Bromo-1-t-butylpyrazole
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- B680178
- Product name
- 4-Bromo-1-t-butylpyrazole
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- J93606
- Product name
- 4-Bromo-1-t-butylpyrazole
- Packaging
- 10g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- HCH0365531
- Product name
- 4-BROMO-1-(TERT-BUTYL)-1H-PYRAZOLE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.92
- Updated
- 2021/12/16
- Product number
- A348528
- Product name
- 4-Bromo-1-(tert-butyl)-1H-pyrazole
- Purity
- 95%
- Packaging
- 1g
- Price
- $16
- Updated
- 2021/12/16
4-bromo-1-tert-butyl-1H-pyrazole Chemical Properties,Usage,Production
Synthesis
15754-60-6
70951-85-8
1. N-bromosuccinimide (NBS, 2.63 kg, 14.79 mol) was added batchwise to a solution of 1-tert-butylpyrazole (1.75 kg, 14.09 mol) in dichloromethane (12.9 kg) in an ice bath at 0°C to 10°C. The reaction was carried out by gas chromatography (GC). 2. The reaction mixture was kept stirred at 0 °C until the content of 1-tert-butylpyrazole was below 30% as shown by gas chromatography (GC) analysis. 3. the reaction mixture was gradually warmed to room temperature with continued stirring until the GC analysis showed that the content of 1-tert-butylpyrazole was less than 1.0%. 4. Upon completion of the reaction, 10% aqueous sodium bisulfite was added to the reaction mixture until it no longer showed blue color when detected using KI-starch test paper. 5. The organic phase was washed sequentially with 5% sodium chloride solution and saturated brine. 6. Evaporate the organic phase under pressure to obtain 4-bromo-1-tert-butyl-1H-pyrazole as a brown liquid (2.67 kg, yield 93.4%; GC purity 99.1%).
References
[1] Patent: WO2011/134971, 2011, A1. Location in patent: Page/Page column 16; 17; 72
[2] Patent: WO2008/33999, 2008, A2. Location in patent: Page/Page column 84
[3] Patent: WO2014/1377, 2014, A1. Location in patent: Page/Page column 104
[4] Patent: US2013/40984, 2013, A1. Location in patent: Paragraph 0393-0395
[5] Patent: WO2017/42100, 2017, A1. Location in patent: Page/Page column 43
4-bromo-1-tert-butyl-1H-pyrazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-bromo-1-tert-butyl-1H-pyrazole manufacturers
- Product
- 4-bromo-1-tert-butyl-1H-pyrazole 70951-85-8
- Price
- US $5.50/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 1kg-100kg
- Release date
- 2020-01-10