AT-406

Product Name: AT-406
CAS No.: 1071992-57-8
Chemical Name: AT-406
Synonyms: AT-406;AT-406(HCl);AT-406 (hydrochloride);Xevinapant hydrochloride;(5S,8S,10aR)-N-(Diphenylmethyl)decahydro-5-[[(2S)-2-(methylamino)-1-oxopropyl]amino]-3-(3-methyl-1-oxobutyl)-6-oxo-pyrrolo[1,2-a][1,5]diazocine-8-carboxamide hydrochloride (1:1)
CBNumber: CB32516001
Molecular Formula: C32H44ClN5O4
Formula Weight: 598.19
MOL File: 1071992-57-8.mol

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AT-406 Property

storage temp.: Store at -20°C, sealed storage, away from moisture and light
solubility: DMSO : 175 mg/mL (292.55 mM; Need ultrasonic)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0013793
Product name: AT-406
Purity: 95.00%
Packaging: 5MG
Price: $301.4
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb181200
Product name: AT-406
Purity: >98%
Packaging: 100mg
Price: $838.1
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb181200
Product name: AT-406
Purity: >98%
Packaging: 250mg
Price: $1504.5
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb181200
Product name: AT-406
Purity: >98%
Packaging: 1000mg
Price: $3136.5
Updated: 2021/12/16

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AT-406 Chemical Properties,Usage,Production

Uses

Xevinapant (AT-406) hydrochloride is a potent and orally bioavailable Smac mimetic and an antagonist of the inhibitor of apoptosis proteins (IAPs). Xevinapant hydrochloride binds to XIAP, cIAP1, and cIAP2 proteins with Kis of 66.4, 1.9, and 5.1 nM, respectively. Xevinapant hydrochloride effectively antagonizes XIAP BIR3 protein in a cell-free functional assay, induces rapid degradation of cellular cIAP1 protein, and inhibits cancer cell growth in various human cancer cell lines. Xevinapant hydrochloride is highly effective in induction of apoptosis in xenograft tumors[1][2].

in vivo

Xevinapant (AT-406) hydrochloride is very effective in inhibition of tumor growth in the MDA-MB-231 xenograft model, and has minimal toxicity to animals^[1]. Xevinapant hydrochloride evaluated for its pharmacokinetic (PK) properties in mice, rats, non-human primates and dogs^[1].

Animal Model:	SCID mice bearing MDA-MB-231 xenograft tumors^[1]
Dosage:	30 and 100 mg/kg
Administration:	p.o.; 5 days a week for 2 weeks
Result:	Strongly inhibits tumor growth at 30 and 100 mg/kg and completely inhibits tumor growth during the treatment with 100 mg/kg.

IC 50

cIAP1: 1.9 nM (Ki); cIAP2: 5.1 nM (Ki); XIAP: 66.4 nM (Ki)

References

[1] Cai Q, Sun H, Peng Y, et al. A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment. J Med Chem. 2011;54(8):2714-2726. DOI:10.1021/jm101505d
[2] Brunckhorst MK, et al. AT-406, an orally active antagonist of multiple inhibitor of apoptosis proteins, inhibits progression of human ovarian cancer. Cancer Biol Ther. 2012;13(9):804-811. DOI:10.4161/cbt.20563

AT-406 Preparation Products And Raw materials

Raw materials

Preparation Products

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AT-406 Suppliers

China 52 China Hong Kong 1 United States 3 Global 56

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1493
Advantage: 55

Wuhan Kaymke Chemical Co., Ltd.,

Tel: 027-027-87342388 18086026008
Fax: 027-87342388
Email: sales@kaymke.com
Country: China
ProdList: 3731
Advantage: 55

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4769
Advantage: 55

SPIRO PHARMA

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Email: eric_feng1954@126.com
Country: China
ProdList: 9248
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Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2991
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Medi-tech Bioscientific Co., Ltd.

Tel: 0519-83246372 13585352506
Fax: 0519-83246372
Country: China
ProdList: 1844
Advantage: 58

Jinan ponder chemical co. LTD

Tel: 0531-0000
Email: thinklifescience@163.com
Country: China
ProdList: 19689
Advantage: 58

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View Lastest Price from AT-406 manufacturers

Career Henan Chemical Co

Product: AT-406 1071992-57-8
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-08-04

1071992-57-8, AT-406Related Search:

AT-406

AT-406(HCl)

AT-406 (hydrochloride)

(5S,8S,10aR)-N-(Diphenylmethyl)decahydro-5-[[(2S)-2-(methylamino)-1-oxopropyl]amino]-3-(3-methyl-1-oxobutyl)-6-oxo-pyrrolo[1,2-a][1,5]diazocine-8-carboxamide hydrochloride (1:1)

Xevinapant hydrochloride

1071992-57-8

C32H43N5O4HCl