ChemicalBook > CAS DataBase List > (2E)-N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyanophenyl)-N-[1-(2-cyclopentylethyl)-4-piperidinyl]-2-propenamide
(2E)-N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyanophenyl)-N-[1-(2-cyclopentylethyl)-4-piperidinyl]-2-propenamide
- Product Name
- (2E)-N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyanophenyl)-N-[1-(2-cyclopentylethyl)-4-piperidinyl]-2-propenamide
- CAS No.
- 683746-68-1
- Chemical Name
- (2E)-N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyanophenyl)-N-[1-(2-cyclopentylethyl)-4-piperidinyl]-2-propenamide
- Synonyms
- JNJ 5207787;(E)-N-(1-acetyl-2,3-dihydroindol-6-yl)-3-(3-cyanophenyl)-N-[1-(2-cyclopentylethyl)piperidin-4-yl]prop-2-enamide;trans-N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyanophenyl)-N-[1-(2-cyclopentylethyl)piperidin-4-yl]acrylamide;(2E)-N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyanophenyl)-N-[1-(2-cyclopentylethyl)-4-piperidinyl]-2-propenamide;2-Propenamide, N-(1-acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyanophenyl)-N-[1-(2-cyclopentylethyl)-4-piperidinyl]-, (2E)-
- CBNumber
- CB32518575
- Molecular Formula
- C32H38N4O2
- Formula Weight
- 511
- MOL File
- 683746-68-1.mol
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(2E)-N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyanophenyl)-N-[1-(2-cyclopentylethyl)-4-piperidinyl]-2-propenamide Property
- Density
- 1.22
- storage temp.
- Store at RT
- solubility
- Soluble to 10 mM in DMSO with gentle warming and to 10 mM in ethanol with gentle warming
- form
- Powder
- color
- White to off-white
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 13947
- Product name
- JNJ-5207787
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 13947
- Product name
- JNJ-5207787
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $163
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 13947
- Product name
- JNJ-5207787
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $296
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 13947
- Product name
- JNJ-5207787
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $1184
- Updated
- 2024/03/01
Tocris
- Product number
- 4018
- Product name
- JNJ5207787
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $293
- Updated
- 2021/12/16
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(2E)-N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyanophenyl)-N-[1-(2-cyclopentylethyl)-4-piperidinyl]-2-propenamide Chemical Properties,Usage,Production
Description
JNJ-5207787 is an antagonist of the neuropeptide Y (NPY) receptor Y2 that blocks peptide YY binding (IC50 = 100 nM). It displays 100-fold selectivity for Y2 over other NPY receptors and has minimal effect on a panel of 50 receptors, ion channels, and transporters, except for sodium channel 2. JNJ-5207787 is intraperitoneally bioavailable and brain penetrant in rats, occupying maximally 50% of Y2 receptor binding sites in the hypothalamic area.
Uses
JNJ 5207787 is a small molecule antagonist of the neuropeptide Y Y2 receptor.
(2E)-N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyanophenyl)-N-[1-(2-cyclopentylethyl)-4-piperidinyl]-2-propenamide Preparation Products And Raw materials
Raw materials
Preparation Products
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