2-(4-(5-(3,4-Diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-ylamino)ethanolhydrochloride
- Product Name
- 2-(4-(5-(3,4-Diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-ylamino)ethanolhydrochloride
- CAS No.
- 1094042-01-9
- Chemical Name
- 2-(4-(5-(3,4-Diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-ylamino)ethanolhydrochloride
- Synonyms
- CS-2567;CYM 5442;CYM 5442 HCl;CYM 5442;CYM-5442;CYM 5442 hydrochlori;CYM 5442 hydrochloride;CYM5442 , 1094042-01-9;2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-ylamino)ethanol;Ethanol, 2-[[4-[5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl]-2,3-dihydro-1H-inden-1-yl]amino]-;2-(4-(5-(3,4-Diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-ylamino)ethanolhydrochloride
- CBNumber
- CB32518782
- Molecular Formula
- C23H27N3O4
- Formula Weight
- 409.48
- MOL File
- 1094042-01-9.mol
2-(4-(5-(3,4-Diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-ylamino)ethanolhydrochloride Property
- Boiling point:
- 617.5±65.0 °C(Predicted)
- Density
- 1.27±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: >5mg/mL
- pka
- 14.73±0.10(Predicted)
- form
- A crystalline solid
- color
- Light yellow to light brown
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C1997
- Product name
- CYM-5442
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $393.3
- Updated
- 2025/07/31
- Product number
- C1997
- Product name
- CYM-5442
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $1141
- Updated
- 2025/07/31
- Product number
- 16925
- Product name
- CYM 5442
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 16925
- Product name
- CYM 5442
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $143
- Updated
- 2024/03/01
- Product number
- 16925
- Product name
- CYM 5442
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $229
- Updated
- 2024/03/01
2-(4-(5-(3,4-Diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-ylamino)ethanolhydrochloride Chemical Properties,Usage,Production
Uses
CYM 5442 is an extracellular lipid mediator whose major effects are mediated by G-protein-coupled receptors. These are important for vascular development.
Definition
ChEBI: CYM5442 is an oxadiazole and a ring assembly.
Biochem/physiol Actions
CYM-5442 is a highly-selective S1P1 (Spingosine 1-Phosphate Receptor 1) agonist that activates S1P1-dependent pathways in vitro and to levels of full efficacy in vivo through a hydrophobic pocket, separable from the orthosteric site of S1P binding that is headgroup dependent. This is a different site from those involved in the activities of other agonists such as FTY720 and SEW2871.
in vivo
CYM5442 (1 mg/kg; intraperitoneal injection; daily; for 5 days; adult male albino Wistar rats) treatment shows preserved visual function of visual evoked potentials (VEP). Retinal nerve fiber layer (RNFL) is significantly thicker in the CYM treated-animals compared to the vehicle[2].
| Animal Model: | Adult male albino Wistar rats (8-10 weeks old; 180-230 g) infected ocular endothelin-1 (ET-1)[2] |
| Dosage: | 1 mg/kg |
| Administration: | Intraperitoneal injection; daily; for 5 days |
| Result: | Visual evoked potentials (VEP) showed preserved visual function. Showed significantly higher retinal ganglion cells (RGCs) numbers. |
2-(4-(5-(3,4-Diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-ylamino)ethanolhydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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