ChemicalBook > CAS DataBase List > N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate

N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate

Product Name: N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate
CAS No.: 191868-14-1
Chemical Name: N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate
Synonyms: BIB03304;BIBO 3304;BIBO3304 TFA;BIBO 3304 trifluoroa;BIBO 3304 (BIBO3304);BIBO 3304 trifluoroacetate;BIBO3304 TFA, 10 mM in DMSO;BIBO-3304 (trifluoroacetate salt);(R)-2-(2,2-Diphenylacetamido)-5-guanidino-N-(4-(ureidomethyl)benzyl)pentanamide 2,2,2-trifluoroacetate;N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate
CBNumber: CB32518838
Molecular Formula: C31H36F3N7O5
Formula Weight: 643.67
MOL File: 191868-14-1.mol

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N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate Property

storage temp.: Store at +4°C
solubility: <75.77mg/ml in DMSO; <75.77mg/ml in ethanol
form: solid
color: White
InChIKey: FBMCYYWIBYEOST-NETKZVBLNA-N
SMILES: C(F)(F)(F)C(=O)O.C(C1C=CC=CC=1)(C1C=CC=CC=1)C(=O)N[C@H](CCCNC(N)=N)C(=O)NCC1C=CC(CNC(=O)N)=CC=1 |&1:23,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris

Product number: 2412
Product name: BIBO3304trifluoroacetate
Purity: ≥98%(HPLC)
Packaging: 10
Price: $338
Updated: 2021/12/16

Tocris

Product number: 2412
Product name: BIBO3304trifluoroacetate
Purity: ≥98%(HPLC)
Packaging: 50
Price: $1426
Updated: 2021/12/16

TRC

Product number: B377005
Product name: BIBO3304Trifluoroacetate
Packaging: 1mg
Price: $160
Updated: 2021/12/16

Usbiological

Product number: 254748
Product name: BIBO 3304 trifluoroacetate
Packaging: 10mg
Price: $616
Updated: 2021/12/16

ChemScene

Product number: CS-0029393
Product name: BIBO3304(TFA)
Purity: 99.95%
Packaging: 25mg
Price: $850
Updated: 2021/12/16

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N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate Chemical Properties,Usage,Production

Uses

BIBO 3304 Trifluoroacetate is a high affinity NPY1-R antagonist, that inhibits NPY- and fasting-induced feeding in vivo following central administration. blockade of Y1 receptors may offer a novel anabolic treatment option for improving bone mass.

in vivo

BIBO3304 (30 μg; bilateral paraventricular nucleus injection) attenuates the hyperphagia following fasting^[1].
BIBO3304 (15-60 μg) dose-dependently inhibits the feeding reponse mediated by 1 μg NPY^[1].
BIBO3304 (0.5?μM; p.o.) significantly increases serum insulin levels^[2].

Animal Model:	Adult male Chbb:Thom rats weighing between 300 and 340 g^[1]
Dosage:	30 μg
Administration:	bilateral paraventricular nucleus injection
Result:	Attenuated the hyperphagia following fasting, especially during the first 2 h of refeeding.

Animal Model:	7-week-old C57BL/6JAusb mice^[2]
Dosage:	0.5?μM
Administration:	p.o.
Result:	Significantly increased serum insulin levels.

IC 50

NPY Y₁ receptor

N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate Suppliers

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191868-14-1, N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetateRelated Search:

BIBO 3304 trifluoroacetate

BIBO 3304

BIBO 3304 (BIBO3304)

BIBO3304 TFA

BIBO 3304 trifluoroa

(R)-2-(2,2-Diphenylacetamido)-5-guanidino-N-(4-(ureidomethyl)benzyl)pentanamide 2,2,2-trifluoroacetate

N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate

Inhibitor,Neuropeptide Y Receptor,subtype,BIBO3304,inhibit,insulin,NPY receptor,serum,hyperphagia,BIBO-3304,BIBO-3304 TFA,oral,BIBO3304 TFA,refeeding,BIBO 3304

BIBO-3304 (trifluoroacetate salt)

BIB03304

BIBO3304 TFA, 10 mM in DMSO

191868-14-1

C29H35N7O32CF3CO2H