3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride

Product Name: 3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride
CAS No.: 199655-36-2
Chemical Name: 3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride
Synonyms: CP465022HCl;CP465022; CP-465022;CP 465022 hydrochlor;CP 465022 hydrochloride;CP 465022, 10 mM in DMSO;3-(2-Chlorophenyl)-2-(2-(6-((diethylamino)methyl)pyridin-2-yl)vinyl)-6-fluoroquinazolin-4(3H)-one;3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinone;4(3H)-Quinazolinone, 3-(2-chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-;3-(2-chlorophenyl)-2-(2-6-[(diethylamino)methyl]pyridin-2-ylethenyl)-6-fluoro-3,4-dihydroquinazolin-4-one;3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride
CBNumber: CB32518843
Molecular Formula: C26H24ClFN4O
Formula Weight: 462.95
MOL File: 199655-36-2.mol

More

Less

3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride Property

Boiling point:: 585.0±60.0 °C(Predicted)
Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: Desiccate at RT
solubility: insoluble in H2O; <49.94mg/ml in DMSO
form: solid
pka: 8.51±0.25(Predicted)
color: Yellow

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Tocris

Product number: 2932
Product name: CP465022hydrochloride
Purity: ≥99%(HPLC)
Packaging: 10
Price: $184
Updated: 2021/12/16

Tocris

Product number: 2932
Product name: CP465022hydrochloride
Purity: ≥99%(HPLC)
Packaging: 50
Price: $785
Updated: 2021/12/16

Usbiological

Product number: 255038
Product name: CP 465022 hydrochloride
Packaging: 10mg
Price: $423
Updated: 2021/12/16

TRC

Product number: P398988
Product name: CP465022
Packaging: 50mg
Price: $1260
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009992
Product name: CP 465022 HYDROCHLORIDE
Purity: 95.00%
Packaging: 10MG
Price: $716.1
Updated: 2021/12/16

More

Less

3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride Chemical Properties,Usage,Production

Uses

CP 465022 is an AMPA antagonist.

Biological Activity

cp 465022 hydrochloride is a potent and selective antagonist of ampa receptor with ic50 value of 25 nm [1].the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (ampa receptor) is an ionotropic transmembrane receptor for glutamate and mediates fast synaptic transmission in the central nervous system. ampa receptors are oligomeric assemblies of four protein subunits, glur1-4.cp 465022 hydrochloride is a noncompetitive and selective ampa receptor antagonist. in rat cortical neurons, cp-465022 inhibited currents induced by kainate (100 μm) with ic50 value of 25 nm and completely inhibited at concentration up to 3.2 μm. in hnt human teratocarcinoma cells, cp-465022 inhibited kainate-induced currents with ic50 value of 15 nm, which was mediated by ampa receptors. in cultured cortical neurons stimulated by kainate, cp-465022 dose-dependently inhibited kainate-induced responses by 54% and 88% at 10 nm and 100 nm, respectively [1]. in hek cells expressing the nav1.6 channel, cp465022 dose-dependently inhibited nav1.6-mediated persistent current [2].in rats after stimulation of schaeffer collateral/commissural pathway, cp-465022 reversibly inhibited the evoked population spike amplitude in the ca1 region. in pentylenetetrazole-induced seizure rats, cp-465022 dose-dependently reduced the incidence of tonic seizures, clonic seizures and lethality. cp-465022 inhibited vertical and horizontal locomotor activity with ed50 values of 6.6 and 11.9 mg/kg, respectively [3].

storage

Room temperature (desiccate)

References

[1]. lazzaro jt, paternain av, lerma j, et al. functional characterization of cp-465,022, a selective, noncompetitive ampa receptor antagonist. neuropharmacology, 2002, 42(2): 143-153.
[2]. welch nc, lin w, juranka pf, et al. traditional ampa receptor antagonists partially block na v1.6-mediated persistent current. neuropharmacology, 2008, 55(7): 1165-1171.
[3]. menniti fs, buchan am, chenard bl, et al. cp-465,022, a selective noncompetitive ampa receptor antagonist, blocks ampa receptors but is not neuroprotective in vivo. stroke, 2003, 34(1): 171-176.

3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride Suppliers

China 41 United Kingdom 1 United States 5 Global 47

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Tianjin Derchemist Science & Technology Co., Ltd.

Tel: 22-58627059 13920586291
Fax: 022-58620305
Email: zdcomcon@126.com
Country: China
ProdList: 4015
Advantage: 50

Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 40000
Advantage: 60

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7777
Advantage: 56

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 86249
Advantage: 60

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 9675
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Medi-tech Bioscientific Co., Ltd.

Tel: 0519-83246372 13585352506
Fax: 0519-83246372
Country: China
ProdList: 1844
Advantage: 58

More

Less

View Lastest Price from 3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride manufacturers

Career Henan Chemical Co

Product: 3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride 199655-36-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 1ton
Release date: 2019-12-30

199655-36-2, 3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochlorideRelated Search:

3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride

CP 465022 hydrochloride

CP465022HCl

CP465022; CP-465022

3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinone

CP 465022 hydrochloride,3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride

4(3H)-Quinazolinone, 3-(2-chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-

CP 465022 hydrochlor

(E)-3-(2-chlorophenyl)-2-(2-(6-((diethylamino)methyl)pyridin-2-yl)vinyl)-6-fluoroquinazolin-4(3H)-one hydrochloride

3-(2-chlorophenyl)-2-(2-6-[(diethylamino)methyl]pyridin-2-ylethenyl)-6-fluoro-3,4-dihydroquinazolin-4-one

CP 465022, 10 mM in DMSO

3-(2-Chlorophenyl)-2-(2-(6-((diethylamino)methyl)pyridin-2-yl)vinyl)-6-fluoroquinazolin-4(3H)-one

199655-36-2

C26H24ClFN4OHCl

C26H24ClFN4O