3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride

Product Name: 3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride
CAS No.: 199655-36-2
Chemical Name: 3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride
Synonyms: CP465022HCl;CP465022; CP-465022;CP 465022 hydrochlor;CP 465022 hydrochloride;3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinone;4(3H)-Quinazolinone, 3-(2-chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-;3-(2-chlorophenyl)-2-(2-6-[(diethylamino)methyl]pyridin-2-ylethenyl)-6-fluoro-3,4-dihydroquinazolin-4-one;3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride;(E)-3-(2-chlorophenyl)-2-(2-(6-((diethylamino)methyl)pyridin-2-yl)vinyl)-6-fluoroquinazolin-4(3H)-one hydrochloride;CP 465022 hydrochloride,3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride
CBNumber: CB32518843
Molecular Formula: C26H24ClFN4O
Formula Weight: 462.95
MOL File: 199655-36-2.mol

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3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride Property

Boiling point:: 585.0±60.0 °C(Predicted)
Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: Desiccate at RT
solubility: insoluble in H2O; <49.94mg/ml in DMSO
form: solid
pka: 8.51±0.25(Predicted)
color: Yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 2932
Product name: CP465022hydrochloride
Purity: ≥99%(HPLC)
Packaging: 10
Price: $184
Updated: 2021/12/16

Tocris

Product number: 2932
Product name: CP465022hydrochloride
Purity: ≥99%(HPLC)
Packaging: 50
Price: $785
Updated: 2021/12/16

Usbiological

Product number: 255038
Product name: CP 465022 hydrochloride
Packaging: 10mg
Price: $423
Updated: 2021/12/16

TRC

Product number: P398988
Product name: CP465022
Packaging: 50mg
Price: $1260
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009992
Product name: CP 465022 HYDROCHLORIDE
Purity: 95.00%
Packaging: 10MG
Price: $716.1
Updated: 2021/12/16

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3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride Chemical Properties,Usage,Production

Uses

CP 465022 is an AMPA antagonist.

Biological Activity

cp 465022 hydrochloride is a potent and selective antagonist of ampa receptor with ic50 value of 25 nm [1].the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (ampa receptor) is an ionotropic transmembrane receptor for glutamate and mediates fast synaptic transmission in the central nervous system. ampa receptors are oligomeric assemblies of four protein subunits, glur1-4.cp 465022 hydrochloride is a noncompetitive and selective ampa receptor antagonist. in rat cortical neurons, cp-465022 inhibited currents induced by kainate (100 μm) with ic50 value of 25 nm and completely inhibited at concentration up to 3.2 μm. in hnt human teratocarcinoma cells, cp-465022 inhibited kainate-induced currents with ic50 value of 15 nm, which was mediated by ampa receptors. in cultured cortical neurons stimulated by kainate, cp-465022 dose-dependently inhibited kainate-induced responses by 54% and 88% at 10 nm and 100 nm, respectively [1]. in hek cells expressing the nav1.6 channel, cp465022 dose-dependently inhibited nav1.6-mediated persistent current [2].in rats after stimulation of schaeffer collateral/commissural pathway, cp-465022 reversibly inhibited the evoked population spike amplitude in the ca1 region. in pentylenetetrazole-induced seizure rats, cp-465022 dose-dependently reduced the incidence of tonic seizures, clonic seizures and lethality. cp-465022 inhibited vertical and horizontal locomotor activity with ed50 values of 6.6 and 11.9 mg/kg, respectively [3].

storage

Room temperature (desiccate)

References

[1]. lazzaro jt, paternain av, lerma j, et al. functional characterization of cp-465,022, a selective, noncompetitive ampa receptor antagonist. neuropharmacology, 2002, 42(2): 143-153.
[2]. welch nc, lin w, juranka pf, et al. traditional ampa receptor antagonists partially block na v1.6-mediated persistent current. neuropharmacology, 2008, 55(7): 1165-1171.
[3]. menniti fs, buchan am, chenard bl, et al. cp-465,022, a selective noncompetitive ampa receptor antagonist, blocks ampa receptors but is not neuroprotective in vivo. stroke, 2003, 34(1): 171-176.

3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride Preparation Products And Raw materials

Raw materials

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3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride Suppliers

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View Lastest Price from 3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride manufacturers

Career Henan Chemical Co

Product: 3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride 199655-36-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 1ton
Release date: 2019-12-30

199655-36-2, 3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochlorideRelated Search:

3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride

CP 465022 hydrochloride

CP465022HCl

CP465022; CP-465022

3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinone

CP 465022 hydrochloride,3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride

4(3H)-Quinazolinone, 3-(2-chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-

CP 465022 hydrochlor

(E)-3-(2-chlorophenyl)-2-(2-(6-((diethylamino)methyl)pyridin-2-yl)vinyl)-6-fluoroquinazolin-4(3H)-one hydrochloride

3-(2-chlorophenyl)-2-(2-6-[(diethylamino)methyl]pyridin-2-ylethenyl)-6-fluoro-3,4-dihydroquinazolin-4-one

199655-36-2

C26H24ClFN4OHCl

C26H24ClFN4O