ProTx II
Uses- Product Name
- ProTx II
- CAS No.
- 484598-36-9
- Chemical Name
- ProTx II
- Synonyms
- PT-II;ProTx II;Met6-Cys21;ProToxin-II;ProTx II，TFA;Cys15-Cys25);ProTx II USP/EP/BP;H-Tyr-Cys-Gln-Lys-Trp-Met-Trp-Thr-Cys-Asp-Ser-Glu-Arg-Lys-Cys-Cys-Glu-Gly-Met-Val-Cys-Arg-Leu-Trp-Cys-Lys-Lys-Lys-Leu-Trp-OH(Disulfide bridge：Cys2-Cys16
- CBNumber
- CB32518919
- Molecular Formula
- C168H250N46O41S8
- Formula Weight
- 3826.5862
- MOL File
- 484598-36-9.mol
ProTx II Property
- storage temp.
- -20°C
- solubility
- Soluble to 0.10 mg/ml in 4:1 Acetonitrile : water
- form
- Powder
- color
- White to off-white
- Water Solubility
- Soluble to 1 mg/ml in water
N-Bromosuccinimide Price
- Product number
- 4023
- Product name
- ProTxII
- Packaging
- 100U
- Price
- $173
- Updated
- 2021/12/16
- Product number
- 256339
- Product name
- ProTx II
- Packaging
- 100ug
- Price
- $409
- Updated
- 2021/12/16
- Product number
- B5515
- Product name
- ProTxII
- Packaging
- 100ug
- Price
- $251
- Updated
- 2021/12/16
ProTx II Chemical Properties,Usage,Production
Uses
ProTx-II is a potent, selective Nav1.7 blocker. Voltage-gated sodium channels (Nav) are responsible for transducing extracellular signals into action potentials in excitable cells. The Nav1 family consists of nine sub-types for which selective tools are highly valued. Discovery of subtype-selective tools has been challenging due to conservation of putative binding sites. Nav1.7 is expressed in sensory neurons and is critical for pain processing. ProTx-II, isolated from the tarantula Thrixopelma pruriens, is a potent blocker of Nav1 channels. Although ProTx-II blocks several members of this channel family, it has >100-fold selectivity for Nav1.7. ProTx-II is active in an in vitro model of pain processing. ProTx-II binds to a previously unknown site on the channel, conferring selectivity and increasing its value as a research tool. It blocks Nav1.7 by decreasing conductance and shifting the activation potential in the positive direction, resulting in an overall decrease in excitability.
storage
Store at -20°C