N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide

Product Name: N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide
CAS No.: 839707-37-8
Chemical Name: N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide
Synonyms: CS-2160;CS-2337;Pluripotin;SC1 (Pluripotin);Pluripotin (SC-1);Pluripotin, 10 mM in DMSO;SC-1 (Pluripotin), Dual kinase and GTPase inhibitor;N-(3-(7-((1,3-Dimethyl-1H-pyrazol-5-yl)amino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimid;inhibit,Extracellular signal regulated kinases,Ribosomal S6 Kinase (RSK),SC-1,SC 1,Inhibitor,ERK,S6K,Pluripotin;N-[3-[7-(2,5-Dimethyl-2H-pyrazol-3-ylamino)-1-methyl-2-oxo-1,4-dihydro-2H-pyrimido[4,5-d]pyrimidin-3-yl]-4-methylphenyl]-3-trifluoromethyl-benzamide
CBNumber: CB32521089
Molecular Formula: C27H25F3N8O2
Formula Weight: 550.53
MOL File: 839707-37-8.mol

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N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide Property

Density: 1.43
storage temp.: -20°C
solubility: DMSO: soluble10mg/mL (clear solution)
form: powder
pka: 12.82±0.70(Predicted)
color: white to beige
InChIKey: NBZFRTJWEIHFPF-UHFFFAOYSA-N
SMILES: C(NC1=CC=C(C)C(N2C(=O)N(C)C3=NC(NC4N(C)N=C(C)C=4)=NC=C3C2)=C1)(=O)C1=CC=CC(C(F)(F)F)=C1

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
WGK Germany: 3
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0444
Product name: Pluripotin
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $171.95
Updated: 2025/07/31

Cayman Chemical

Product number: 10009557
Product name: SC-1
Purity: ≥98%
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 10009557
Product name: SC-1
Purity: ≥98%
Packaging: 5mg
Price: $152
Updated: 2024/03/01

Cayman Chemical

Product number: 10009557
Product name: SC-1
Purity: ≥98%
Packaging: 10mg
Price: $275
Updated: 2024/03/01

Cayman Chemical

Product number: 10009557
Product name: SC-1
Purity: ≥98%
Packaging: 25mg
Price: $601
Updated: 2024/03/01

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N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide Chemical Properties,Usage,Production

Uses

Pluripotin is a dual inhibitor of ERK1 and RasGAP with KDs of 98 nM and 212 nM, respectively. Pluripotin also inhibits RSK1, RSK2, RSK3, and RSK4 with IC50s of 0.5, 2.5, 3.3, and 10.0 μM, respectively.

Biological Activity

Pluripotin is an activator of murine embryonic stem (ES) cell self-renewal. It appears th at pluripotin mediates the activity by dual RasGAP and ERK1 inhibition.

IC 50

ERK1: 98 nM (Kd); RasGAP: 212 nM (Kd); RSK1: 0.5 μM (IC₅₀); RSK2: 2.5 μM (IC₅₀); RSK3: 3.3 μM (IC₅₀); RSK4: 10 μM (IC₅₀)

storage

-20°C

References

[1] Chen S, et al. Self-renewal of embryonic stem cells by a small molecule. Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17266-71. DOI:10.1073/pnas.0608156103
[2] Mertins SD, et al. A small molecule (pluripotin) as a tool for studying cancer stem cell biology: proof of concept. PLoS One. 2013;8(2):e57099. DOI:10.1371/journal.pone.0057099

N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide Suppliers

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View Lastest Price from N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide manufacturers

Career Henan Chemical Co

Product: N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide 839707-37-8
Price: US $1.00/KG
Min. Order: 100KG
Purity: 99.0%
Supply Ability: 1000kg
Release date: 2020-03-11

839707-37-8, N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamideRelated Search:

SC1 (Pluripotin)

N-(3-(7-((1,3-Dimethyl-1H-pyrazol-5-yl)amino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimid

N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide

Pluripotin

Pluripotin (SC-1)

N-[3-[7-[(1,3-Dimethyl-1H-pyrazol-5-yl)amino]-1,4-dihydro-1-methyl-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)benzamide

CS-2337

CS-2160

N-[3-[7-(2,5-Dimethyl-2H-pyrazol-3-ylamino)-1-methyl-2-oxo-1,4-dihydro-2H-pyrimido[4,5-d]pyrimidin-3-yl]-4-methylphenyl]-3-trifluoromethyl-benzamide

inhibit,Extracellular signal regulated kinases,Ribosomal S6 Kinase (RSK),SC-1,SC 1,Inhibitor,ERK,S6K,Pluripotin

Benzamide, N-[3-[7-[(1,3-dimethyl-1H-pyrazol-5-yl)amino]-1,4-dihydro-1-methyl-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)-

SC-1 (Pluripotin), Dual kinase and GTPase inhibitor

Pluripotin, 10 mM in DMSO

839707-37-8

C27H25F3N8O2

Aromatics

Heterocycles

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals