Ethyl 3-bromo-2-oxobutyrate
- Product Name
- Ethyl 3-bromo-2-oxobutyrate
- CAS No.
- 57332-84-0
- Chemical Name
- Ethyl 3-bromo-2-oxobutyrate
- Synonyms
- Ethyl 3-bromo-2-oxobutyrate;Ethyl α-BroMoethylglyoxalate;Ethyl 3-bromo-2-oxobutanoate;Ethyl a-Bromoethylglyoxalate;3-Bromo-2-oxobutyrate ethyl ester;3-Bromo-2-oxo-butyric acid ethyl ester;3-Bromo-2-oxobutanoic acid ethyl ester;3-bromo-2-keto-butyric acid ethyl ester;Butanoic acid, 3-bromo-2-oxo-, ethyl ester;Ethyl α-bromoethylglyoxalate, CAS 57332-84-0
- CBNumber
- CB32521140
- Molecular Formula
- C6H9BrO3
- Formula Weight
- 209.04
- MOL File
- 57332-84-0.mol
Ethyl 3-bromo-2-oxobutyrate Property
- Boiling point:
- 213℃
- Density
- 1.474
- Flash point:
- 83℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform, Ethyl Acetate (Slightly), Methanol (Slightly)
- form
- Oil
- color
- Clear Colourless to Pale Yellow
- InChI
- InChI=1S/C6H9BrO3/c1-3-10-6(9)5(8)4(2)7/h4H,3H2,1-2H3
- InChIKey
- SIOIQIWIQSMQAG-UHFFFAOYSA-N
- SMILES
- C(OCC)(=O)C(=O)C(Br)C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E900300
- Product name
- Ethylα-Bromoethylglyoxalate
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- E900300
- Product name
- Ethylα-Bromoethylglyoxalate
- Packaging
- 25g
- Price
- $1340
- Updated
- 2021/12/16
- Product number
- 70105
- Product name
- Ethylα-Bromoethylglyoxalate
- Packaging
- 10g
- Price
- $700
- Updated
- 2021/12/16
- Product number
- 080992
- Product name
- Ethyl 3-bromo-2-oxobutanoate
- Packaging
- 5g
- Price
- $445
- Updated
- 2021/12/16
- Product number
- 080992
- Product name
- Ethyl 3-bromo-2-oxobutanoate
- Packaging
- 1g
- Price
- $149
- Updated
- 2021/12/16
Ethyl 3-bromo-2-oxobutyrate Chemical Properties,Usage,Production
Chemical Properties
Ethyl 3-bromo-2-oxobutyrate is Clear Colourless Oil
Uses
Ethyl α-Bromoethylglyoxalate is used in the preparations of potential positron emission tomography tracers for neuropeptide Y Y1 receptors.
Uses
Ethyl 3-bromo-2-oxobutyrate is used in the preparations of potential positron emission tomography tracers for neuropeptide Y Y1 receptors.
Synthesis Reference(s)
The Journal of Organic Chemistry, 67, p. 1102, 2002 DOI: 10.1021/jo010630z
Synthesis
15933-07-0
57332-84-0
Step A: Synthesis of ethyl 3-bromo-2-oxobutanoate (1-B). Bromine (1.89 mL, 36.9 mmol) was added slowly and dropwise to a solution of ethyl 2-oxobutyrate (1-A, 4.8 g, 36.9 mmol) in dichloromethane (20 mL) at 5 °C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 18 hours. Upon completion of the reaction, the reaction mixture was purged with nitrogen to remove residual bromine. Subsequently, the reaction mixture was diluted with ethyl acetate and the organic phase was washed sequentially with 10% sodium bicarbonate solution (2 times), water and saturated saline. The organic layer was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give ethyl 3-bromo-2-oxobutanoate as a yellow oil (1-B, 7.50 g, 97% yield).1H-NMR (CDCl3) data: δ 5.15-5.20 (q, 1H), 4.32-4.45 (m, 2H), 1.82-1.85 (d, 3H), 1.38- 1.41 (t, 3H).
References
[1] Patent: US2012/149699, 2012, A1. Location in patent: Page/Page column 14-15
[2] Journal of Medicinal Chemistry, 2005, vol. 48, # 6, p. 1823 - 1838
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 3, p. 1116 - 1139
[4] Patent: WO2016/4105, 2016, A1. Location in patent: Paragraph 00146
[5] Tetrahedron, 2013, vol. 69, # 2, p. 474 - 480
Ethyl 3-bromo-2-oxobutyrate Preparation Products And Raw materials
Raw materials
Preparation Products
Ethyl 3-bromo-2-oxobutyrate Suppliers
- Tel
- 15005869072
- tzcyhxkj@163.com
- Country
- China
- ProdList
- 507
- Advantage
- 58
- Tel
- 021-15995002467 15995002467
- chen_shuming@126.com
- Country
- China
- ProdList
- 148
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 0512-63263366 18912765016
- Fax
- 0512-6326 3366
- tongtf110@sina.com
- Country
- China
- ProdList
- 993
- Advantage
- 62
- Tel
- 13598610367 0373-7129549
- Fax
- 0373-8369699
- 2468833170@qq.com
- Country
- China
- ProdList
- 932
- Advantage
- 58
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9510
- Advantage
- 58
- Tel
- 18652989687
- Fax
- +86-25-52131256
- sales@norris-pharm.com
- Country
- China
- ProdList
- 8878
- Advantage
- 55
- Tel
- 021-33632979
- Fax
- 021-34692979
- info@tsbiochem.com
- Country
- China
- ProdList
- 8065
- Advantage
- 58
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60