1,2-Dihydro-2-oxo-5-pyrimidinecarboxylic acid ethyl ester
Uses- Product Name
- 1,2-Dihydro-2-oxo-5-pyrimidinecarboxylic acid ethyl ester
- CAS No.
- 95928-49-7
- Chemical Name
- 1,2-Dihydro-2-oxo-5-pyrimidinecarboxylic acid ethyl ester
- Synonyms
- Ethyl 2-Hydroxy-5-pyrimidinecarboxylate;ethyl 2-oxo-1H-pyrimidine-5-carboxylate;Ethyl 1,2-dihydro-2-oxo-5-pyrimidinecarboxylate;Ethyl 2-oxo-1,2-dihydro-5-pyrimidinecarboxylate;2-Hydroxy-pyrimidine-5-carboxylic acid ethyl ester;1,2-Dihydro-2-oxo-5-pyrimidinecarboxylic acid ethyl ester;2-Oxo-1,2-dihydro-pyrimidine-5-carboxylic acid ethyl ester;PyriMidin-5-carboxylic acid 1,2-dihydro-2-oxo-, ethyl ester;5-PyriMidinecarboxylic acid, 1,2-dihydro-2-oxo-, ethyl ester;1,2-Dihydro-2-oxo-5-pyrimidinecarboxylic acid ethyl ester ISO 9001：2015 REACH
- CBNumber
- CB32521201
- Molecular Formula
- C7H8N2O3
- Formula Weight
- 168.15
- MOL File
- 95928-49-7.mol
1,2-Dihydro-2-oxo-5-pyrimidinecarboxylic acid ethyl ester Property
- Density
- 1.33
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 8.18±0.10(Predicted)
- Appearance
- Off-white to yellow Solid
Safety
- Safety Statements
- 24/25
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E945773
- Product name
- Ethyl2-hydroxypyrimidine-5-carboxylate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FD153713
- Product name
- 1,2-Dihydro-2-oxo-5-pyrimidinecarboxylic acid ethyl ester
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- JK146809
- Product name
- Ethyl2-hydroxypyrimidine-5-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $198
- Updated
- 2021/12/16
- Product number
- 129574
- Product name
- 2-Oxo-1,2-dihydro-pyrimidine-5-carboxylicacidethylester
- Purity
- 95%+
- Packaging
- 500mg
- Price
- $288
- Updated
- 2021/12/16
- Product number
- OR939066
- Product name
- Ethyl2-hydroxypyrimidine-5-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $300
- Updated
- 2021/12/16
1,2-Dihydro-2-oxo-5-pyrimidinecarboxylic acid ethyl ester Chemical Properties,Usage,Production
Uses
Ethyl 2-oxo-1,2-dihydropyrimidine-5-carboxylate is an important fine chemical raw material that is readily soluble in water and organic solvents. Its structure exhibits interconversion between enol and ketone forms.
Synthesis
The target compound ethyl 2-oxo-1,2-dihydropyrimidine-5-carboxylate was prepared by using urea and substituting 2,4-pentanedione as starting materials:
To a three-necked reaction flask equipped with a stirrer and a thermometer, urea, ethanol 35mL, substituting 2,4-pentanedione and hydrochloric acid 15mL were added in turn. the reaction was stirred for a period of time at a certain temperature, cooled naturally, and concentrated in a reduced-pressure water bath (water temperature <45 ) with a rotary evaporator. Decompression water bath concentration (water temperature <45 ), cooling, to the concentrate add ethanol, ether 20 ml, filtration, drying. 2-oxo-1,2-dihydropyrimidine-5-carboxylic acid, ethanol and acid catalysts, the reaction process heating evaporation of the water generated, no longer have water distillation, indicating the end of the reaction. After evaporating the excess ethanol, the solution was cooled. The product was washed repeatedly with water and 10% aqueous NaHCO3 to a pH of about 7. Reduced pressure distillation was carried out and the 112-114 C fraction was collected as the white crystalline product ethyl 2-oxo-1,2-dihydropyrimidine-5-carboxylate. The reaction process was changed from standing to stirring, which is favorable for accelerating the reaction rate and improving the yield; the product is easily soluble in water and organic solvents, and in the literature, it was filtered directly after the reaction, at this time, there existed water in the hydrochloric acid and ethanol added to the reaction system, and the direct filtration would make the product dissolved therein be lost, and we improved the process by firstly concentrating the reaction solution in the reduced-pressure water bath, to remove most of the water and ethanol, and then add a small amount of ethanol and ether to filter out the product, reducing the loss caused by filtration, thus increasing the yield.
References
[1] Patent: US2009/76006, 2009, A1. Location in patent: Page/Page column 31; 40
[2] Patent: WO2018/85342, 2018, A1. Location in patent: Page/Page column 26; 27
[3] Chemical and Pharmaceutical Bulletin, 2000, vol. 48, # 10, p. 1504 - 1513
[4] Patent: US2011/152295, 2011, A1. Location in patent: Page/Page column 24
[5] Patent: WO2011/130628, 2011, A1. Location in patent: Page/Page column 138
1,2-Dihydro-2-oxo-5-pyrimidinecarboxylic acid ethyl ester Preparation Products And Raw materials
Raw materials
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View Lastest Price from 1,2-Dihydro-2-oxo-5-pyrimidinecarboxylic acid ethyl ester manufacturers
- Product
- 1,2-Dihydro-2-oxo-5-pyrimidinecarboxylic acid ethyl ester 95928-49-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-12
- Product
- 1,2-Dihydro-2-oxo-5-pyrimidinecarboxylic acid ethyl ester 95928-49-7
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 98%MIN
- Supply Ability
- ASK
- Release date
- 2019-12-25