5-(1H-Pyrrol-1-yl)-1H-benzo[d]imidazole-2-thiol
- Product Name
- 5-(1H-Pyrrol-1-yl)-1H-benzo[d]imidazole-2-thiol
- CAS No.
- 172152-53-3
- Chemical Name
- 5-(1H-Pyrrol-1-yl)-1H-benzo[d]imidazole-2-thiol
- Synonyms
- 5-(1H-pyrrol-1-yl)-1H-benzo[d]iMidazole-2-thiol;Ilaprazole Impurity A;Ilaprazole Intermediate 2;Enavogliflozin Impurity 21;Ilaprazole intermediate P-3;5-Pyrrol-1-yl-1H-benzoimidazole-2-thiol;5-(1H-Pyroll-1-yl)-2-Mercaptobenzimidazole;5-(1H-Pyrrol-1-yl)-2-mercaptobenzimidazole;5-(1H-purrole-1-yl)-2-marcapto- benzimidazole;5-pyrrol-1-yl-1,3-dihydrobenzimidazole-2-thione
- CBNumber
- CB32521216
- Molecular Formula
- C11H9N3S
- Formula Weight
- 215.27
- MOL File
- 172152-53-3.mol
5-(1H-Pyrrol-1-yl)-1H-benzo[d]imidazole-2-thiol Property
- Boiling point:
- 381.7±44.0 °C(Predicted)
- Density
- 1.40
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 9.61±0.30(Predicted)
- color
- White to Pale Green
- InChI
- InChI=1S/C11H9N3S/c15-11-12-9-4-3-8(7-10(9)13-11)14-5-1-2-6-14/h1-7H,(H2,12,13,15)
- InChIKey
- YYXGYVYKGRUILQ-UHFFFAOYSA-N
- SMILES
- C1(=S)NC2=CC=C(N3C=CC=C3)C=C2N1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CHM0390405
- Product name
- 5-(1H-PYRROL-1-YL)-1H-BENZO[D]IMIDAZOLE-2-THIOL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.94
- Updated
- 2021/12/16
- Product number
- 172152533
- Product name
- 5-(1H-Pyrrol-1-yl)-1H-benzo[d]imidazole-2-thiol
- Packaging
- 1g
- Price
- $400
- Updated
- 2021/12/16
- Product number
- CM162085
- Product name
- 5-(1H-Pyrrol-1-yl)-2-mercaptobenzimidazole
- Purity
- 95%
- Packaging
- 5g
- Price
- $777
- Updated
- 2021/12/16
- Product number
- CD11233680
- Product name
- 5-(1H-Pyrrol-1-yl)-1H-benzo[d]imidazole-2-thiol
- Purity
- 95+%
- Packaging
- 5g
- Price
- $831
- Updated
- 2021/12/16
- Product number
- A7973
- Product name
- 1,3-dihydro-5-(1H-pyrrol-1-yl)-2H-Benzimidazole-2-thione
- Purity
- 97.00%
- Packaging
- 1G
- Price
- $1740
- Updated
- 2021/12/16
5-(1H-Pyrrol-1-yl)-1H-benzo[d]imidazole-2-thiol Chemical Properties,Usage,Production
Uses
5-(1H-Pyrrol-1-yl)-2-mercaptobenzimidazole is a pharmaceutical intermediate compound used in the synthesis of various drugs such as ilaprazole, gastric and ulcer drugs.
Synthesis
Water (100ml) and anhydrous sodium acetate (16.02g, 0.20mole) were added, and then 2-mercapto-5- aminobenzimidazole (32.27g, 0.20mole),2,5-dimethoxytetrahydrofuran (28.4g, 0.21mole), and acetic acid (100ml) were added. Then, stirring was carried out at 5O℃ for 4 hours. The resultant product was cooled to 50C, and tetrahydrofuran (420ml) was added. The mixture was neutralized with a sodium hydroxide aqueous solution, and water (130ml) was added to carry out layer- separation. Then, an organic layer was washed with a sodium hydroxide aqueous solution. The organic layer was dried by anhydrous magnesium sulfate and concentrated, and then crystallized by ethyl acetate and n-hexane to provide a final compound, that is 5-(1H-Pyrrol-1-yl)-1H-benzo[d]imidazole-2-thiol. Yield: 35.7g (85%)
5-(1H-Pyrrol-1-yl)-1H-benzo[d]imidazole-2-thiol Preparation Products And Raw materials
Raw materials
Preparation Products
5-(1H-Pyrrol-1-yl)-1H-benzo[d]imidazole-2-thiol Suppliers
- Tel
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- Country
- India
- ProdList
- 17
- Advantage
- 58
View Lastest Price from 5-(1H-Pyrrol-1-yl)-1H-benzo[d]imidazole-2-thiol manufacturers
- Product
- 5-(1H-Pyrrol-1-yl)-2-mercaptobenzimidazole 172152-53-3
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 10 tons
- Release date
- 2021-08-09
- Product
- 5-(1H-Pyrrol-1-yl)-2-mercaptobenzimidazole 172152-53-3
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2020-04-24
- Product
- 5-(1H-Pyrrol-1-yl)-2-mercaptobenzimidazole 172152-53-3
- Price
- US $0.00/KG Ton
- Min. Order
- 1KG Ton
- Purity
- 99%+
- Supply Ability
- 2 tons/month
- Release date
- 2022-10-09