H-Pro-Gly-Pro-OH
- Product Name
- H-Pro-Gly-Pro-OH
- CAS No.
- 7561-51-5
- Chemical Name
- H-Pro-Gly-Pro-OH
- Synonyms
- Pro-Gly-Pro;H-Pro-Gly-Pro-OH;L-Prolylglycyl-L-proline;L-Proline, L-prolylglycyl-;(2S)-1-[2-[[(2S)-pyrrolidine-2-carbonyl]amino]acetyl]pyrrolidine-2-carboxylicacid
- CBNumber
- CB32523821
- Molecular Formula
- C12H19N3O4
- Formula Weight
- 269.3
- MOL File
- 7561-51-5.mol
H-Pro-Gly-Pro-OH Property
- form
- Solid
- color
- White to off-white
- Sequence
- H-Pro-Gly-Pro-OH
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
H-Pro-Gly-Pro-OH Chemical Properties,Usage,Production
Uses
H-Pro-Gly-Pro-OH is a collagen-derived matrikine that has classically been described as a neutrophil chemoattractant. H-Pro-Gly-Pro-OH is perfectly positioned to focus neutrophils on the site required and direct a localized repair response. H-Pro-Gly-Pro-OH activates the transcription of neurotrophins and their receptor genes after cerebral ischemia[1][2].
in vivo
H-Pro-Gly-Pro-OH (37.5 μg/kg; i.p.) activates the transcription of neurotrophins and their receptor genes after cerebral ischemia in rats[2].
| Animal Model: | 270-320 g, male Wistar rats (focal cerebral ischemia)[2] |
| Dosage: | 37.5 μg/kg |
| Administration: | I.p.; 15, 1 h, 4, 8, 24, 28, 32, 48, 52, and 56 h |
| Result: | Enhanced the transcription of Bdnf and TrkC 3 h after pMCAO and Ngf, TrkB, TrkC, and TrkA 24 h after pMCAO. |
References
[1] Patel DF, et al. The multifaceted roles of the matrikine Pro-Gly-Pro in pulmonary health and disease. Eur Respir Rev. 2018 Jun 27;27(148):180017. DOI:10.1183/16000617.0017-2018
[2] Dmitrieva VG, et al. Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia. Cell Mol Neurobiol. 2010 Jan;30(1):71-9. DOI:10.1007/s10571-009-9432-0
H-Pro-Gly-Pro-OH Preparation Products And Raw materials
Raw materials
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