2-(4-bromobenzyl)-1H-isoindole-1,3(2H)-dione
- Product Name
- 2-(4-bromobenzyl)-1H-isoindole-1,3(2H)-dione
- CAS No.
- 153171-22-3
- Chemical Name
- 2-(4-bromobenzyl)-1H-isoindole-1,3(2H)-dione
- Synonyms
- 132582;N-(4-Bromobenzyl)phthalimide;2-(4-broMobenzyl)isoindoline-1,3-dione;2-(4-bromobenzyl)-1H-isoindole-1,3(2H)-dione;2-[(4-bromophenyl)methyl]isoindole-1,3-dione;2-[(4-Bromophenyl)methyl]-1H-isoindol-1,3(2H)-dione;2-[(4-Bromophenyl)methyl]-1H-isoindole-1,3(2H)-dione;1H-Isoindole-1,3(2H)-dione, 2-[(4-bromophenyl)methyl]-
- CBNumber
- CB32524323
- Molecular Formula
- C15H10BrNO2
- Formula Weight
- 316.15
- MOL File
- 153171-22-3.mol
2-(4-bromobenzyl)-1H-isoindole-1,3(2H)-dione Property
- Melting point:
- 133 °C
- Boiling point:
- 445.7±28.0 °C(Predicted)
- Density
- 1.604±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- -2.29±0.20(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 0507CE
- Product name
- 2-(4-Bromobenzyl)isoindoline-1,3-dione
- Packaging
- 250mg
- Price
- $139
- Updated
- 2021/12/16
- Product number
- HCH0362639
- Product name
- 2-(4-BROMOBENZYL)ISOINDOLINE-1,3-DIONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.42
- Updated
- 2021/12/16
- Product number
- CD11249109
- Product name
- 2-(4-Bromobenzyl)isoindoline-1,3-dione
- Purity
- 95+%
- Packaging
- 5g
- Price
- $544
- Updated
- 2021/12/16
- Product number
- CM147532
- Product name
- 2-(4-Bromobenzyl)-1H-isoindole-1,3(2H)-dione
- Purity
- 95%
- Packaging
- 5g
- Price
- $593
- Updated
- 2021/12/16
- Product number
- 153171223
- Product name
- 2-(4-Bromobenzyl)isoindoline-1,3-dione
- Packaging
- 1g
- Price
- $172.8
- Updated
- 2021/12/16
2-(4-bromobenzyl)-1H-isoindole-1,3(2H)-dione Chemical Properties,Usage,Production
Synthesis
1074-82-4
589-15-1
153171-22-3
(a) A reaction mixture of p-bromobenzyl bromide (4.00 g, 16.004 mmol) and phthalimide potassium salt (3.26 g, 17.61 mmol) in N,N-dimethylformamide (DMF, 10 mL) was subjected to an oil bath at 100 °C, CaCl2 was added as a desiccant, and the reaction was stirred for 6 hours. After completion of the reaction, the reaction was cooled to room temperature, the reaction was quenched by the addition of deionized water (100 mL), and the reaction mixture was extracted with ethyl acetate (AcOEt, 100 mL x 3). The organic phases were combined, washed sequentially with deionized water (100 mL×1) and saturated saline (100 mL×1), dried over anhydrous sodium sulfate (Na2SO4), filtered, and concentrated under reduced pressure to afford 2-(4-bromobenzyl)isoindoline-1,3-dione (5.28 g, quantitative yield) as a colorless solid. Colorless cottony crystals were obtained by recrystallization from hexane/ethyl acetate mixed solvent. Melting point 126-129 °C. 1H NMR (300 MHz, CDCl3) δ 4.80 (2H, s, CH2), 7.32 (2H, d, J = 7.8 Hz, ArH), 7.44 (2H, d, J = 8.1 Hz, ArH), 7.71-7.73 (2H, m, ArH), 7.84-7.85 (2H, m, ArH ).
References
[1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 14, p. 3720 - 3731
[2] Chemistry - A European Journal, 2010, vol. 16, # 33, p. 10171 - 10177
[3] Journal of the Chemical Society, 1931, p. 1225,1232
[4] Tetrahedron, 1993, vol. 49, # 43, p. 9855 - 9866
[5] Patent: WO2015/103317, 2015, A1. Location in patent: Page/Page column 271
2-(4-bromobenzyl)-1H-isoindole-1,3(2H)-dione Preparation Products And Raw materials
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