6-Bromo-4-aza-2-oxindole
- Product Name
- 6-Bromo-4-aza-2-oxindole
- CAS No.
- 1190319-62-0
- Chemical Name
- 6-Bromo-4-aza-2-oxindole
- Synonyms
- 6-Bromo-4-aza-2-oxindole;6-bromo-1H-pyrrolo[3,2-b]pyridin-2(3H)-one;6-broMo-1H,2H,3H-pyrrolo[3,2-b]pyridin-2-one;3-bromo-6,7-dihydropyrrolo[3,4-b]pyridin-5-one;6-bromo-1,3-dihydro-2H-pyrrolo[3,2-b]pyridin-2-one;2H-Pyrrolo[3,2-b]pyridin-2-one, 6-bromo-1,3-dihydro-
- CBNumber
- CB32525254
- Molecular Formula
- C7H5BrN2O
- Formula Weight
- 213.03
- MOL File
- 1190319-62-0.mol
6-Bromo-4-aza-2-oxindole Property
- Boiling point:
- 345.7±42.0 °C(Predicted)
- Density
- 1.768±0.06 g/cm3(Predicted)
- storage temp.
- Store at room temperature
- pka
- 12.03±0.20(Predicted)
- Appearance
- Light brown to brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B698918
- Product name
- 6-Bromo-1h-pyrrolo[3,2-b]pyridin-2(3h)-one
- Packaging
- 25mg
- Price
- $195
- Updated
- 2021/12/16
- Product number
- B698918
- Product name
- 6-Bromo-1h-pyrrolo[3,2-b]pyridin-2(3h)-one
- Packaging
- 100mg
- Price
- $420
- Updated
- 2021/12/16
- Product number
- HCH0367673
- Product name
- 6-BROMO-1H-PYRROLO[3,2-B]PYRIDIN-2(3H)-ONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.43
- Updated
- 2021/12/16
- Product number
- CS-W006294
- Product name
- 6-Bromo-1H-pyrrolo[3,2-b]pyridin-2(3H)-one
- Purity
- 98.09%
- Packaging
- 5g
- Price
- $575
- Updated
- 2021/12/16
- Product number
- 4H48-9-93
- Product name
- 6-Bromo-4-aza-2-oxindole
- Packaging
- 1g
- Price
- $980
- Updated
- 2021/12/16
6-Bromo-4-aza-2-oxindole Chemical Properties,Usage,Production
Synthesis
1379312-86-3
1190319-62-0
Step 3: Ethyl 2-(3-amino-5-bromopyridin-2-yl)acetate (3.5 g, 13.5 mmol) was dissolved in 97 mL of aqueous HCl (97 mmol). The reaction mixture was stirred at 50 °C for 18 hours. Upon completion of the reaction, the mixture was cooled to room temperature and solid NaHCO3 was slowly added to neutralize the acidity. Subsequently, the aqueous layer was extracted with ethyl acetate (3 x 100 mL). The organic layers were combined, washed sequentially with water and brine and dried over anhydrous Na2SO4. Concentration of the organic phase under reduced pressure afforded the target compound 6-bromo-1H-pyrrolo[3,2-b]pyridin-2(3H)-one (1.9 g, 8.12 mmol, 60% yield) as a tan solid.LCMS analysis showed a calculated value of [M + H]+ of 215 and a measured value of 215, which was in accordance with the expected isotopic distribution pattern.
References
[1] Journal of Medicinal Chemistry, 2012, vol. 55, # 17, p. 7667 - 7685
[2] Patent: WO2016/8593, 2016, A1. Location in patent: Page/Page column 110; 111
6-Bromo-4-aza-2-oxindole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Bromo-4-aza-2-oxindole manufacturers
- Product
- 6-BroMo-1,3-dihydropyrrolo[3,2-b]pyridin-2-one 1190319-62-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 6-Bromo-4-aza-2-oxindole 1190319-62-0
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-09
- Product
- 6-Bromo-4-aza-2-oxindole 1190319-62-0
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%； 99%
- Supply Ability
- 1kg; 5kg; 10kg；25kg
- Release date
- 2020-01-07