3-Amino-5-methylpyridine-2-carbonitrile
- Product Name
- 3-Amino-5-methylpyridine-2-carbonitrile
- CAS No.
- 1001635-30-8
- Chemical Name
- 3-Amino-5-methylpyridine-2-carbonitrile
- Synonyms
- 3-aMino-5-Methylpicolinonitrile;3-AMino-2-cyano-5-Methylpyridine;3-aMino-5-Methylpyridin-2-carbonitrile;3-Amino-5-methylpyridine-2-carbonitrile;3-amino-5-methyl-2-Pyridinecarbonitrile;2-Pyridinecarbonitrile,3-aMino-5-Methyl-;3-amino-5-methyl-pyridine-2-carbonitrile - [A72074];3-Amino-5-methylpyridine-2-carbonitrile ISO 9001：2015 REACH;3-Amino-5-methylpicolinonitrile, 3-Amino-2-cyano-5-methylpyridine
- CBNumber
- CB32527632
- Molecular Formula
- C7H7N3
- Formula Weight
- 133.15
- MOL File
- 1001635-30-8.mol
3-Amino-5-methylpyridine-2-carbonitrile Property
- Boiling point:
- 370.3±42.0 °C(Predicted)
- Density
- 1.18
- storage temp.
- 2-8°C(protect from light)
- form
- crystal
- pka
- 0.91±0.20(Predicted)
- color
- brown
N-Bromosuccinimide Price
- Product number
- 300730
- Product name
- 3-Amino-5-methyl-2-pyridinecarbonitrile, 99%
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- A12843
- Product name
- 3-Amino-5-methylpyridine-2-carbonitrile
- Purity
- 97%
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- OR60181
- Product name
- 3-Amino-5-methylpyridine-2-carbonitrile
- Packaging
- 1g
- Price
- $88
- Updated
- 2021/12/16
- Product number
- 3H37-1-8P
- Product name
- 3-Amino-5-methylpyridine-2-carbonitrile
- Packaging
- 1g
- Price
- $104
- Updated
- 2021/12/16
- Product number
- 300730
- Product name
- 3-Amino-5-methyl-2-pyridinecarbonitrile, 99%
- Packaging
- 10g
- Price
- $385
- Updated
- 2021/12/16
3-Amino-5-methylpyridine-2-carbonitrile Chemical Properties,Usage,Production
Uses
3-Amino-2-cyano-5-methylpyridine is a versatile reactant used in the preparation of new series of orally bioavailable chemokine receptor 9 (CCR9) antagonists with potential use for treatment of inflammatory bowel disease.
Synthesis
557-21-1
34552-13-1
1001635-30-8
Under argon protection, 1.0 g (7 mmol, 1 eq.) of 2-chloro-5-methylpyridin-3-amine was dissolved in 15 mL of anhydrous N,N-dimethylformamide (DMF) in a 20 mL reaction vial. Subsequently, 821 mg (7 mmol, 1 equiv) of zinc cyanide (Zn(CN)2) was added. After degassing the reaction system for 10 min, 405 mg (0.35 mmol, 0.05 eq.) of tetrakis(triphenylphosphine)palladium(0) (Pd(PPh3)4) was added. The reaction mixture was heated to 105 °C and the reaction was stirred at this temperature for 20 hours. After completion of the reaction, the mixture was filtered through diatomaceous earth and the filtrate was concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: ethyl acetate/petroleum ether, 2/8, v/v) to afford the white solid target product 3-amino-2-cyano-5-methylpyridine in 65% yield. The melting point of the product was 154 °C. Infrared spectrum (diamond ATR, cm^-1) ν: 3404, 2216, 1600, 1465, 1339, 1230, 858, 739; 1H NMR (400 MHz, CDCl3) δ: 2.34 (s, 3H, CH3), 4.37 (br s, 2H, NH2), 6.93 (d, 1H, J = 2.4 Hz. Harom), 7.93 (d, 1H, J = 2.4 Hz, Harom); 13C NMR (101 MHz, CDCl3) δ: 28.7 (CH3), 114.9 (CH), 116.3 (CN), 122.6 (CH), 138.6 (Cq), 142.2 (CH), 146.3 (Cq).
References
[1] Patent: US2015/203489, 2015, A1. Location in patent: Paragraph 0660; 0661
3-Amino-5-methylpyridine-2-carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
3-Amino-5-methylpyridine-2-carbonitrile Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 001-857-928-2050 or 1-888-588-9418
- Fax
- 001-617-206-9595
- sales@chemreagents.com
- Country
- United States
- ProdList
- 10186
- Advantage
- 62
- Tel
- 025-83697070 13770331960
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 16059
- Advantage
- 64
- Tel
- +86(24) 31938773(O)
- Fax
- qq:174941352
- sales@co-chem.com
- Country
- China
- ProdList
- 225
- Advantage
- 62
- Tel
- 022-58013646 13011382049
- Fax
- 022-23854368
- sales@jinyudachem.com
- Country
- China
- ProdList
- 1944
- Advantage
- 55
- Tel
- +86057186818502 13588463833
- Fax
- Pls mail us for more information!
- info@sagechem.com
- Country
- China
- ProdList
- 10266
- Advantage
- 58
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9520
- Advantage
- 58
- Tel
- +86-18068513926
- Fax
- 0086-519-85153711
- Country
- China
- ProdList
- 1277
- Advantage
- 55
- Tel
- 400-400-164-7117 18317119277
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39999
- Advantage
- 60
- Tel
- 021-021-56795766
- Fax
- +86-21-56795266
- sales@worldyachem.com
- Country
- China
- ProdList
- 9478
- Advantage
- 58
View Lastest Price from 3-Amino-5-methylpyridine-2-carbonitrile manufacturers
- Product
- 3-Amino-5-methylpyridine-2-carbonitrile 1001635-30-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-03
- Product
- 3-Amino-5-methylpyridine-2-carbonitrile 1001635-30-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-25
- Product
- 3-Amino-5-methylpyridine-2-carbonitrile 1001635-30-8
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08