3-Morpholin-4-yl-5,6-dihydro-1H-pyridin-2-one
- Product Name
- 3-Morpholin-4-yl-5,6-dihydro-1H-pyridin-2-one
- CAS No.
- 545445-40-7
- Chemical Name
- 3-Morpholin-4-yl-5,6-dihydro-1H-pyridin-2-one
- Synonyms
- RSYY(Apremilast)-34;3-Morpholino-5,6-dihydropyridin-2(1H)-one;5-morpholin-4-yl-2,3-dihydro-1H-pyridin-6-one;3-Morpholin-4-yl-5,6-dihydro-1H-pyridin-2-one;5,6-Dihydro-3-(4-morpholinyl)-2(1H)-pyridinone;3-(4-Morpholinyl)-5,6-dihydro-2(1H)-pyridinone;2(1H)-Pyridinone, 5,6-dihydro-3-(4-morpholinyl)-;3-Morpholin-4-yl-5,6-dihydro-1H-pyridin-2-one ISO 9001：2015 REACH
- CBNumber
- CB32534568
- Molecular Formula
- C9H14N2O2
- Formula Weight
- 182.22
- MOL File
- 545445-40-7.mol
3-Morpholin-4-yl-5,6-dihydro-1H-pyridin-2-one Property
- Boiling point:
- 432.7±45.0 °C(Predicted)
- Density
- 1.195
- storage temp.
- 2-8°C
- pka
- 14.66±0.40(Predicted)
- Appearance
- White to yellow Solid
- InChI
- InChI=1S/C9H14N2O2/c12-9-8(2-1-3-10-9)11-4-6-13-7-5-11/h2H,1,3-7H2,(H,10,12)
- InChIKey
- SRICXDSOENVWEU-UHFFFAOYSA-N
- SMILES
- C1(=O)NCCC=C1N1CCOCC1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- FD76308
- Product name
- 5,6-Dihydro-3-(4-morpholinyl)-2(1H)-pyridinone
- Packaging
- 250mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- FD76308
- Product name
- 5,6-Dihydro-3-(4-morpholinyl)-2(1H)-pyridinone
- Packaging
- 500mg
- Price
- $170
- Updated
- 2021/12/16
- Product number
- FD76308
- Product name
- 5,6-Dihydro-3-(4-morpholinyl)-2(1H)-pyridinone
- Packaging
- 1g
- Price
- $260
- Updated
- 2021/12/16
- Product number
- FD76308
- Product name
- 5,6-Dihydro-3-(4-morpholinyl)-2(1H)-pyridinone
- Packaging
- 2g
- Price
- $350
- Updated
- 2021/12/16
- Product number
- FD76308
- Product name
- 5,6-Dihydro-3-(4-morpholinyl)-2(1H)-pyridinone
- Packaging
- 5G
- Price
- $400
- Updated
- 2021/12/16
3-Morpholin-4-yl-5,6-dihydro-1H-pyridin-2-one Chemical Properties,Usage,Production
Synthesis
110-91-8
41419-12-9
545445-40-7
The general procedure for the synthesis of 5,6-dihydro-3-(4-morpholinyl)-2(1H)-pyridinone from morpholine and 3,3-dichloro-2-piperidinone was as follows: 100 g (0.60 mmol) of 3,3-dichloro-2-piperidinone was dissolved in 400 mL of 1,4-dioxane at room temperature, followed by the addition of 60 mL (0.66 mmol) morpholine and 210 mL (1.50 mmol) of triethylamine. The reaction mixture was heated to 110°C and the progress of the reaction was monitored by thin layer chromatography (TLC). The reaction was completed after about 4.5 h. The reaction mixture was cooled to room temperature, during which time a solid precipitated. The solid was separated by filtration and the filtrate was distilled under reduced pressure to remove the solvent to give a yellow solid. The solid was washed sequentially with ether (2 x 400 mL) and water (2 x 200 mL) and dried to give a white solid powder 5,6-dihydro-3-(4-morpholinyl)-2(1H)-pyridinone 100.5 g (theoretical yield 108.5 g) in 92% yield.
References
[1] Patent: CN104513239, 2017, B. Location in patent: Paragraph 0197; 0238; 0241; 0242
[2] Monatshefte fur Chemie, 2017, vol. 148, # 8, p. 1477 - 1482
[3] Patent: CN104327074, 2016, B. Location in patent: Paragraph 0151; 0152; 0153
[4] Patent: CN104311558, 2016, B. Location in patent: Paragraph 0150; 0151; 0152
[5] Patent: CN104277041, 2016, B. Location in patent: Paragraph 0155; 0156; 0157
3-Morpholin-4-yl-5,6-dihydro-1H-pyridin-2-one Preparation Products And Raw materials
Raw materials
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View Lastest Price from 3-Morpholin-4-yl-5,6-dihydro-1H-pyridin-2-one manufacturers
- Product
- 3-Morpholin-4-yl-5,6-dihydro-1H-pyridin-2-one 545445-40-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-13
- Product
- 3-Morpholin-4-yl-5,6-dihydro-1H-pyridin-2-one 545445-40-7
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-11