ChemicalBook > CAS DataBase List > NS 5806

NS 5806

Product Name: NS 5806
CAS No.: 426834-69-7
Chemical Name: NS 5806
Synonyms: NS 5806;NS5806, 10 mM in DMSO;1-(3,5-Bis(trifluoromethyl)phenyl)-3-(2,4-dibromo-6-(1H-tetrazol-5-yl)phenyl)urea;N-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]--N'-[2,4-DIBROMO-6-(2H-TETRAZOL-5-YL)PHENYL]UREA;N-[3,5-bis(trifluoromethyl)phenyl]-N′-[2,4-dibromo-6-(1H-tetrazol-5-yl)phenyl]-urea;Urea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-[2,4-dibromo-6-(2H-tetrazol-5-yl)phenyl]-;1-[3,5-bis(trifluoromethyl)phenyl]-3-[2,4-dibromo-6-(1H-1,2,3,4-tetrazol-5-yl)phenyl]urea;Potassium Channel,KV4.3,Inhibitor,KcsA,dacay,NS 5806,peak,KChIP2,Ito,KV4.2,current,inhibit,amplitudes,NS5806
CBNumber: CB32535686
Molecular Formula: C16H8Br2F6N6O
Formula Weight: 574.07
MOL File: 426834-69-7.mol

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NS 5806 Property

Density: 1.962±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: >30mg/mL
form: powder
pka: 3.54±0.10(Predicted)
color: white to faint yellow
InChI: InChI=1S/C16H8Br2F6N6O/c17-8-4-10(13-27-29-30-28-13)12(11(18)5-8)26-14(31)25-9-2-6(15(19,20)21)1-7(3-9)16(22,23)24/h1-5H,(H2,25,26,31)(H,27,28,29,30)
InChIKey: UZWJWROOLOOCPQ-UHFFFAOYSA-N
SMILES: N(C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)C(NC1=C(C2=NNN=N2)C=C(Br)C=C1Br)=O

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N2540
Product name: NS5806
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $142.5
Updated: 2025/07/31

Sigma-Aldrich

Product number: N2540
Product name: NS5806
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $579
Updated: 2025/07/31

Tocris

Product number: 4166
Product name: NS5806
Purity: ≥99%(HPLC)
Packaging: 10
Price: $244
Updated: 2021/12/16

Tocris

Product number: 4166
Product name: NS5806
Purity: ≥99%(HPLC)
Packaging: 50
Price: $1027
Updated: 2021/12/16

TRC

Product number: N926038
Product name: NS5806
Packaging: 5mg
Price: $415
Updated: 2021/12/16

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NS 5806 Chemical Properties,Usage,Production

Uses

NS5806, a potent potassium current activator, increases KV4.3/KChIP2 peak current amplitudes with an EC50 of 5.3 μM. NS5806 slows KV4.3 and KV4.2 current dacay in channel complexes containing KChIP2[1].

Biochem/physiol Actions

NS5806 increases peak current amplitude of the potassium channel Kv4.3 (EC50 = 5.3 uM). NS5806 also slows Kv4.3 and Kv4.2 current dacay in channel complexes containing KChIP2. In ventricular cardiomycytes, NS5806 increases transient outward current and reproduces the electrocardiographic profile of Brugada syndrome.

storage

Store at +4°C

References

[1] Lundby A, et al. Effect of the I(to) activator NS5806 on cloned KV4 channels depends on the accessory protein KChIP2. Br J Pharmacol. 2010 Aug;160(8):2028-44. doi: 10.1111/j.1476-5381.2010.00859.x. DOI:10.1111/j.1476-5381.2010.00859.x
[2] Cheng H, et al. Differential responses of rabbit ventricular and atrial transient outward current (Ito) to the Itomodulator NS5806. Physiol Rep. 2017 Mar;5(5). pii: e13172. DOI:10.14814/phy2.13172

NS 5806 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from NS 5806 manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: NS 5806 426834-69-7
Price: US $2.00-5.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-07-08

426834-69-7, NS 5806Related Search:

NS 5806

N-[3,5-bis(trifluoromethyl)phenyl]-N′-[2,4-dibromo-6-(1H-tetrazol-5-yl)phenyl]-urea

N-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]--N'-[2,4-DIBROMO-6-(2H-TETRAZOL-5-YL)PHENYL]UREA

Urea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-[2,4-dibromo-6-(2H-tetrazol-5-yl)phenyl]-

Potassium Channel,KV4.3,Inhibitor,KcsA,dacay,NS 5806,peak,KChIP2,Ito,KV4.2,current,inhibit,amplitudes,NS5806

1-[3,5-bis(trifluoromethyl)phenyl]-3-[2,4-dibromo-6-(1H-1,2,3,4-tetrazol-5-yl)phenyl]urea

NS5806, 10 mM in DMSO

1-(3,5-Bis(trifluoromethyl)phenyl)-3-(2,4-dibromo-6-(1H-tetrazol-5-yl)phenyl)urea

426834-69-7

C16H8Br2F6N6O