4-chlorothieno[3,2-d]pyriMidine-6-carboxylic acid
- Product Name
- 4-chlorothieno[3,2-d]pyriMidine-6-carboxylic acid
- CAS No.
- 875515-76-7
- Chemical Name
- 4-chlorothieno[3,2-d]pyriMidine-6-carboxylic acid
- Synonyms
- 4-chlorothieno[3,2-d]pyriMidine-6-carboxylic acid;4-Chlorothieno[3,2-d]pyrimidine-6-carboxylic acid - [C5334]
- CBNumber
- CB32546398
- Molecular Formula
- C7H3ClN2O2S
- Formula Weight
- 215
- MOL File
- 875515-76-7.mol
4-chlorothieno[3,2-d]pyriMidine-6-carboxylic acid Property
- Density
- 1.731
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- solid
- Appearance
- Yellow to brown Solid
Safety
- RIDADR
- UN2811
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C411503
- Product name
- 4-Chlorothieno[3,2-d]pyrimidine-6-carboxylicacid
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 8H66-5-4A
- Product name
- 4-Chlorothieno[3,2-d]pyrimidine-6-carboxylic acid
- Packaging
- 250mg
- Price
- $288
- Updated
- 2021/12/16
- Product number
- HCH0366229
- Product name
- 4-CHLOROTHIENO[3,2-D]PYRIMIDINE-6-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $302.4
- Updated
- 2021/12/16
- Product number
- OR53050
- Product name
- 4-Chlorothieno[3,2-d]pyrimidine-6-carboxylicacid
- Packaging
- 1g
- Price
- $682
- Updated
- 2021/12/16
- Product number
- 8H66-5-4A
- Product name
- 4-Chlorothieno[3,2-d]pyrimidine-6-carboxylic acid
- Packaging
- 1g
- Price
- $752
- Updated
- 2021/12/16
4-chlorothieno[3,2-d]pyriMidine-6-carboxylic acid Chemical Properties,Usage,Production
Synthesis
124-38-9
16269-66-2
875515-76-7
To a stirred solution of 2,2,6,6-tetramethylpiperidine (1.484 mL, 8.79 mmol) in anhydrous THF (15 mL) was added slowly and dropwise 2.5 M n-butyllithium hexane solution (3.52 mL, 8.79 mmol) at 0 °C and under nitrogen protection. The reaction mixture was continued to be stirred at 0 °C for 30 min. Subsequently, the mixture was slowly added to a solution of anhydrous THF (15 mL) of 4-chlorothieno[3,2-d]pyrimidine (Compound 12; 1.00 g, 5.86 mmol) in a controlled dropwise manner over 30 min and the reaction temperature was maintained at -78 °C. After the reaction continued to stir at -78 °C for 1 h, dry ice (2.58 g, 58.6 mmol) was added to the reaction system. Subsequently, the reaction mixture was allowed to slowly warm up to room temperature over a period of 2 hours. After completion of the reaction, the reaction mixture was diluted with ethyl acetate (100 mL) and washed with 0.1 M hydrochloric acid. The organic layer was dried over anhydrous magnesium sulfate and concentrated to dryness under reduced pressure to afford 4-chlorothieno[3,2-d]pyrimidine-6-carboxylic acid (Compound 13; 1.1 g, 83% yield). Mass spectrometry (ESI) data: calculated value for C7H3ClN2O2 was 213.96; measured value was 215.0 [M + H].
References
[1] Journal of Medicinal Chemistry, 2013, vol. 56, # 9, p. 3666 - 3679
[2] Patent: WO2014/138562, 2014, A1. Location in patent: Page/Page column 63
4-chlorothieno[3,2-d]pyriMidine-6-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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