BMS 195614

Product Name: BMS 195614
CAS No.: 253310-42-8
Chemical Name: BMS 195614
Synonyms: BMS 195614;4-[[[5,6-Dihydro-5,5-dimethyl-8-(3-quinolinyl)-2-naphthalenyl]carbonyl]amino]benzoic acid;BMS-195614 4-[[[5,6-Dihydro-5,5-dimethyl-8-(3-quinolinyl)-2-naphthalenyl]carbonyl]amino]benzoic acid
CBNumber: CB32546787
Molecular Formula: C29H24N2O3
Formula Weight: 448.51246
MOL File: 253310-42-8.mol

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BMS 195614 Property

storage temp.: Store at -20°C
solubility: <11.21mg/ml in DMSO

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 3660
Product name: BMS195614
Purity: ≥98%(HPLC)
Packaging: 10
Price: $266
Updated: 2021/12/16

Tocris

Product number: 3660
Product name: BMS195614
Purity: ≥98%(HPLC)
Packaging: 50
Price: $1088
Updated: 2021/12/16

Usbiological

Product number: 254786
Product name: BMS 195614
Packaging: 10mg
Price: $516
Updated: 2021/12/16

TRC

Product number: B695580
Product name: BMS195614
Packaging: 2.5mg
Price: $250
Updated: 2021/12/16

ApexBio Technology

Product number: B7459
Product name: BMS195614
Packaging: 10mg
Price: $261
Updated: 2021/12/16

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BMS 195614 Chemical Properties,Usage,Production

Uses

BMS 195614, is a selective neutral RARα inhibitor and exhibits no significant effect on NCoR binding. It decreases agonist-induced coactivator recruitment and SMRT binding to RAR. RARs, or Retinoic Acid Receptors, are nuclear hormone receptors that form heterodimers with RXRs (Retinoid X Receptors).

Definition

ChEBI: BMS 195614 is a carboxamide resulting from the formal condensation of the carboxy group of 5,5-dimethyl-8-(quinolin-3-yl)-5,6-dihydronaphthalene-2-carboxylic acid with the amino group of p-aminobenzoic acid. It is a neutral retinoic acid receptor (RAR) alpha-selective antagonist (Ki = 2.5 nM). It displays no significant effect on nuclear receptor corepressor (NCoR) binding; moderately decreases SMRT binding to RAR. It antagonizes agonist-induced coactivator (CoA) recruitment. It has a role as a retinoic acid receptor alpha antagonist. It is a member of quinolines, a member of benzoic acids and a secondary carboxamide.

BMS 195614 Preparation Products And Raw materials

Raw materials

Preparation Products

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BMS 195614 Suppliers

China 22 United Kingdom 1 United States 6 Global 29

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253310-42-8, BMS 195614Related Search:

BMS 195614

4-[[[5,6-Dihydro-5,5-dimethyl-8-(3-quinolinyl)-2-naphthalenyl]carbonyl]amino]benzoic acid

BMS-195614 4-[[[5,6-Dihydro-5,5-dimethyl-8-(3-quinolinyl)-2-naphthalenyl]carbonyl]amino]benzoic acid

253310-42-8