BMS 195614
- Product Name
- BMS 195614
- CAS No.
- 253310-42-8
- Chemical Name
- BMS 195614
- Synonyms
- BMS 195614;4-[[[5,6-Dihydro-5,5-dimethyl-8-(3-quinolinyl)-2-naphthalenyl]carbonyl]amino]benzoic acid;BMS-195614 4-[[[5,6-Dihydro-5,5-dimethyl-8-(3-quinolinyl)-2-naphthalenyl]carbonyl]amino]benzoic acid
- CBNumber
- CB32546787
- Molecular Formula
- C29H24N2O3
- Formula Weight
- 448.51246
- MOL File
- 253310-42-8.mol
BMS 195614 Property
- storage temp.
- Store at -20°C
- solubility
- <11.21mg/ml in DMSO
N-Bromosuccinimide Price
- Product number
- 3660
- Product name
- BMS195614
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $266
- Updated
- 2021/12/16
- Product number
- 3660
- Product name
- BMS195614
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $1088
- Updated
- 2021/12/16
- Product number
- B695580
- Product name
- BMS195614
- Packaging
- 2.5mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- 254786
- Product name
- BMS 195614
- Packaging
- 10mg
- Price
- $516
- Updated
- 2021/12/16
- Product number
- B7459
- Product name
- BMS195614
- Packaging
- 5mg
- Price
- $147
- Updated
- 2021/12/16
BMS 195614 Chemical Properties,Usage,Production
Uses
BMS 195614, is a selective neutral RARα inhibitor and exhibits no significant effect on NCoR binding. It decreases agonist-induced coactivator recruitment and SMRT binding to RAR. RARs, or Retinoic Acid Receptors, are nuclear hormone receptors that form heterodimers with RXRs (Retinoid X Receptors).
Definition
ChEBI: BMS 195614 is a carboxamide resulting from the formal condensation of the carboxy group of 5,5-dimethyl-8-(quinolin-3-yl)-5,6-dihydronaphthalene-2-carboxylic acid with the amino group of p-aminobenzoic acid. It is a neutral retinoic acid receptor (RAR) alpha-selective antagonist (Ki = 2.5 nM). It displays no significant effect on nuclear receptor corepressor (NCoR) binding; moderately decreases SMRT binding to RAR. It antagonizes agonist-induced coactivator (CoA) recruitment. It has a role as a retinoic acid receptor alpha antagonist. It is a member of quinolines, a member of benzoic acids and a secondary carboxamide.
BMS 195614 Preparation Products And Raw materials
Raw materials
Preparation Products
BMS 195614 Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77