2-Amino-5-methyl-3-thiophenecarbonitrile

Product Name: 2-Amino-5-methyl-3-thiophenecarbonitrile
CAS No.: 138564-58-6
Chemical Name: 2-Amino-5-methyl-3-thiophenecarbonitrile
Synonyms: 2-Amino-5-m;AKOS MSC-0403;TIMTEC-BB SBB000075;2-Amino-5-methyl-3-t;Olanzapine Impurity 7;Olanzapine Impurity 1;Olanzapine Impurity 13;Olanzapine impurity SA;Olanzapine impurity BNB;2-Amino-3-cyano-5-methyl
CBNumber: CB3254936
Molecular Formula: C6H6N2S
Formula Weight: 138.19
MOL File: 138564-58-6.mol

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2-Amino-5-methyl-3-thiophenecarbonitrile Property

Melting point:: 101-103°C
Boiling point:: 318.5±42.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: soluble in Methanol
form: powder to crystal
pka: 0.16±0.10(Predicted)
color: Light yellow to Brown
InChI: InChI=1S/C6H6N2S/c1-4-2-5(3-7)6(8)9-4/h2H,8H2,1H3
InChIKey: YGXADLPRHBRTPG-UHFFFAOYSA-N
SMILES: C1(N)SC(C)=CC=1C#N
CAS DataBase Reference: 138564-58-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 20/21/22-22
Safety Statements: 22-36/37/39
RIDADR: 3276
HazardClass: IRRITANT
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: A2351
Product name: 2-Amino-5-methyl-3-thiophenecarbonitrile
Purity: >98.0%(GC)
Packaging: 5g
Price: $30
Updated: 2025/07/31

TCI Chemical

Product number: A2351
Product name: 2-Amino-5-methyl-3-thiophenecarbonitrile
Purity: >98.0%(GC)
Packaging: 25g
Price: $98
Updated: 2025/07/31

TRC

Product number: A618260
Product name: 2-Amino-5-methyl-3-thiophenecarbonitrile
Packaging: 1g
Price: $110
Updated: 2021/12/16

Usbiological

Product number: 259370
Product name: 2-Amino-5-methyl-3-thiophenecarbonitrile
Packaging: 1g
Price: $446
Updated: 2021/12/16

Apolloscientific

Product number: OR10162
Product name: 2-Amino-5-methylthiophene-3-carbonitrile
Purity: 97%
Packaging: 5g
Price: $15
Updated: 2021/12/16

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2-Amino-5-methyl-3-thiophenecarbonitrile Chemical Properties,Usage,Production

Uses

An Impurity generated in the preparation of Olanzapine (O253750).

Synthesis

123-38-6

109-77-3

138564-58-6

General procedure for the synthesis of 2-amino-3-cyano-5-methylthiophene from propionaldehyde and malononitrile: 0.070 g of 4-propylcyclohexanone (0.5 mmol), 0.030 g of malononitrile (0.5 mmol), 0.019 g of powdered sulphur (0.6 mmol), and 0.1 cm3 of NaOH (4 mol/dm3 aqueous solution) in a 1 cm3 choline chloride The mixture/urea was stirred at 60°C for 2-3 hours. The progress of the reaction was monitored by TLC and when the reaction was complete, 5 cm3 of water was added. The solid product was separated by filtration and recrystallized with ethanol if necessary to obtain the pure target compound.

References

[1] Monatshefte fur Chemie, 2017, vol. 148, # 4, p. 711 - 716
[2] Research on Chemical Intermediates, 2018, vol. 44, # 3, p. 2195 - 2213
[3] Patent: WO2008/50341, 2008, A2. Location in patent: Page/Page column 32; 33
[4] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 7, p. 1953 - 1956
[5] Journal of Pharmaceutical Sciences, 2001, vol. 90, # 3, p. 371 - 388

2-Amino-5-methyl-3-thiophenecarbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-5-methyl-3-thiophenecarbonitrile Suppliers

Americas 1 Canada 2 China 246 Europe 4 Germany 5 India 56 Japan 3 Russia 1 South Korea 1 The Netherlands 1 Ukraine 1 United Kingdom 14 United States 46 Global 381

Taizhou Changyuan Chemical Technology Co., Ltd.

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Energy Chemical

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View Lastest Price from 2-Amino-5-methyl-3-thiophenecarbonitrile manufacturers

R&D Scientific Inc.

Product: 2-Amino-5-methylthiophene-3-carbonitrile 138564-58-6
Price: US $790.00/g
Min. Order: 1g
Purity: 97
Supply Ability: 500 Kg
Release date: 2024-02-19

Honest Joy Holdings Limited

Product: 2-Amino-5-methylthiophene-3-carbonitrile 138564-58-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 100 tons
Release date: 2022-01-26

Qiuxian Baitai New Material Co., LTD

Product: 2-amino-3-cyano-5-methylthiophene 138564-58-6
Price: US $2.00/g
Min. Order: 1KG
Purity: 99%
Supply Ability: 5ton/Month
Release date: 2021-12-21

138564-58-6, 2-Amino-5-methyl-3-thiophenecarbonitrileRelated Search:

Olanzapine Impurity K Olanzapine dimer 5-Methyl-2-[(2-nitrophenyl)amino]thiophene-3-carbonitrile Olanzapine ThioacetoxyMethylidene IMpurity Discontinued Olanzapine Impurity(ADP-2b) 4-Amino-2-methyl-10H-thiene[2,3-b][1,5]benzodiazepine hydrochloride IMp. A (EP): 5-Methyl-2-[(2-nitrophenyl)-aMino]thiophene-3-carbonitrile HydroxyMethylidene thione Olanzapine Benzoate Olanzapine Impurity(ADP-2c) 1-Fluoro-2-nitrobenzene 2-(1,2-PhenylenediaMino)-5-Methylthiphene-3-carbonitrile Olanzapine iMpurity (1-(5'-Methylthiophen-2'-yl)-1,3-dihydrobenzoiMidazol-2-one) 2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE 2-AMINO-6-METHYL-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE 2-AMINO-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHENE-3-CARBONITRILE Methyl 5-amino-4-cyano-3-methylthiophene-2-carboxylate 6-(DIMETHOXYMETHYL)-2-MERCAPTONICOTINONITRILE

2-Amino-5-Methyl-3-Nitrothiophene

2-Amino-5-methylthiopene-3-carbonitrile

3-Thiophenecarbonitrile, 2-amino-5-methyl-

2-Amino-5-methyl-3-t

2-Amino-3-cyano-5-methyl

3-Thiophenecarbonitrile,2-amino-5-methyl-(9CI)

TIMTEC-BB SBB000075

2-AMINO-5-METHYL-3-CYANOTHIOPHENE

2-AMINO-5-METHYL-3-THIOPHENECARBONITRILE

2-AMINO-5-METHYLTHIOPEHNE-3-CARBONITRILE

2-AMINO-5-METHYLTHIOPHENE-3-CARBONITRILE

2-AMINO-3-CYANO-5-METHYLTHIOPHENE

Olanzapine Impurity 7

AKOS MSC-0403

Olanzapine Impurity 1

2-Amino-5-m

Olanzapine Impurity 13

2-Amino-5-methyl-3-thiophenecarbonitrile &gt

Olanzapine impurity BNB

Olanzapine impurity SA

2-Amino-5-methyl-3-thiophenecarbonitrile ISO 9001：2015 REACH

Olanzapine ImpurityQ: What is Olanzapine Impurity Q: What is the CAS Number of Olanzapine Impurity Q: What is the storage condition of Olanzapine Impurity Q: What are the applications of Olanzapine Impurity

Olanzapine intermediates

2-Amino -5methythiopene-3-carbonitrile

2‐Amino‐5‐methylthiophene‐3‐ carbonitrile?(DN1)

2-Amino-5-methyl-3-thiophenecarbonitrile, 10 mM in DMSO

138564-58-6

138654-58-6

1632539-06-1

C6H6N2S

Aromatics, Heterocycles, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals

Olanzapine

Heterocycle-oher series

Thiophene&Benzothiophene

Amines

(intermediate of olanzapine)

NITRILE

138564-58-6

OLED