ChemicalBook > CAS DataBase List > 2-Amino-5-methyl-3-thiophenecarbonitrile

2-Amino-5-methyl-3-thiophenecarbonitrile

Product Name
2-Amino-5-methyl-3-thiophenecarbonitrile
CAS No.
138564-58-6
Chemical Name
2-Amino-5-methyl-3-thiophenecarbonitrile
Synonyms
2-Amino-5-m;AKOS MSC-0403;TIMTEC-BB SBB000075;2-Amino-5-methyl-3-t;Olanzapine Impurity 7;Olanzapine Impurity 1;Olanzapine Impurity 13;Olanzapine impurity SA;Olanzapine impurity BNB;2-Amino-3-cyano-5-methyl
CBNumber
CB3254936
Molecular Formula
C6H6N2S
Formula Weight
138.19
MOL File
138564-58-6.mol
More
Less

2-Amino-5-methyl-3-thiophenecarbonitrile Property

Melting point:
101-103°C
Boiling point:
318.5±42.0 °C(Predicted)
Density 
1.26±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
soluble in Methanol
form 
powder to crystal
pka
0.16±0.10(Predicted)
color 
Light yellow to Brown
InChI
InChI=1S/C6H6N2S/c1-4-2-5(3-7)6(8)9-4/h2H,8H2,1H3
InChIKey
YGXADLPRHBRTPG-UHFFFAOYSA-N
SMILES
C1(N)SC(C)=CC=1C#N
CAS DataBase Reference
138564-58-6(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi,Xn
Risk Statements 
20/21/22-22
Safety Statements 
22-36/37/39
RIDADR 
3276
HazardClass 
IRRITANT
HS Code 
29349990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
A2351
Product name
2-Amino-5-methyl-3-thiophenecarbonitrile
Purity
>98.0%(GC)
Packaging
5g
Price
$30
Updated
2025/07/31
TCI Chemical
Product number
A2351
Product name
2-Amino-5-methyl-3-thiophenecarbonitrile
Purity
>98.0%(GC)
Packaging
25g
Price
$98
Updated
2025/07/31
TRC
Product number
A618260
Product name
2-Amino-5-methyl-3-thiophenecarbonitrile
Packaging
1g
Price
$110
Updated
2021/12/16
Usbiological
Product number
259370
Product name
2-Amino-5-methyl-3-thiophenecarbonitrile
Packaging
1g
Price
$446
Updated
2021/12/16
Apolloscientific
Product number
OR10162
Product name
2-Amino-5-methylthiophene-3-carbonitrile
Purity
97%
Packaging
5g
Price
$15
Updated
2021/12/16
More
Less

2-Amino-5-methyl-3-thiophenecarbonitrile Chemical Properties,Usage,Production

Uses

An Impurity generated in the preparation of Olanzapine (O253750).

Synthesis

123-38-6

109-77-3

138564-58-6

General procedure for the synthesis of 2-amino-3-cyano-5-methylthiophene from propionaldehyde and malononitrile: 0.070 g of 4-propylcyclohexanone (0.5 mmol), 0.030 g of malononitrile (0.5 mmol), 0.019 g of powdered sulphur (0.6 mmol), and 0.1 cm3 of NaOH (4 mol/dm3 aqueous solution) in a 1 cm3 choline chloride The mixture/urea was stirred at 60°C for 2-3 hours. The progress of the reaction was monitored by TLC and when the reaction was complete, 5 cm3 of water was added. The solid product was separated by filtration and recrystallized with ethanol if necessary to obtain the pure target compound.

References

[1] Monatshefte fur Chemie, 2017, vol. 148, # 4, p. 711 - 716
[2] Research on Chemical Intermediates, 2018, vol. 44, # 3, p. 2195 - 2213
[3] Patent: WO2008/50341, 2008, A2. Location in patent: Page/Page column 32; 33
[4] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 7, p. 1953 - 1956
[5] Journal of Pharmaceutical Sciences, 2001, vol. 90, # 3, p. 371 - 388

2-Amino-5-methyl-3-thiophenecarbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2-Amino-5-methyl-3-thiophenecarbonitrile Suppliers

Americas 1 Canada 2 China 245 Europe 4 Germany 5 India 56 Japan 3 Russia 1 South Korea 1 The Netherlands 1 Ukraine 1 United Kingdom 14 United States 46 Global 380
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
Accela ChemBio Inc.
Tel
+1(858) 699-3322
Fax
+1(858) 876-1948
Email
marketing@accelachem.com
Country
United States
ProdList
6024
Advantage
65
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
AbaChemScene
Tel
732-484-9848
Fax
888-484-5008
Email
sales@chemscene.com
Country
United States
ProdList
3982
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
Standardpharm Co. Ltd.
Tel
86-714-3992388
Email
overseasales1@yongstandards.com
Country
United States
ProdList
14332
Advantage
58
Cato Research Chemicals Inc.
Tel
+86-020-81960175-877 4000-868-328
Email
tianwen.zhan@cato-chem.com
Country
United States
ProdList
10404
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Synthonix Inc
Tel
--
Fax
--
Email
info@synthonix.com
Country
United States
ProdList
6872
Advantage
58
HBCChem, Inc.
Tel
--
Fax
--
Email
Sales@hbcchem-inc.com
Country
United States
ProdList
887
Advantage
50
Barath Biosciences, Inc.
Tel
--
Fax
--
Email
barath@barathbiosciences.com
Country
United States
ProdList
203
Advantage
58
Alichem Inc.
Tel
--
Fax
--
Email
sales@alichem.com
Country
United States
ProdList
6167
Advantage
58
SynQuest Laboratories, Inc.,
Tel
--
Fax
--
Country
United States
ProdList
2301
Advantage
58
Wilshire Technologies
Tel
--
Fax
--
Country
United States
ProdList
428
Advantage
58
Wilshire Technologies, Inc.
Tel
--
Fax
--
Email
info@wilshiretechnologies.com
Country
United States
ProdList
893
Advantage
58
Meruvax Pharma (North America)
Tel
--
Fax
--
Country
United States
ProdList
91
Advantage
58
CHEM-IS-TRY, Inc.
Tel
--
Fax
--
Email
sales@chem-is-try.com
Country
United States
ProdList
551
Advantage
56
HBCChem Inc.
Tel
--
Fax
--
Email
sales@hbcchem-inc.com
Country
United States
ProdList
4569
Advantage
30
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Fragmenta
Tel
--
Fax
--
Email
sales@fragmenta.com
Country
United States
ProdList
1068
Advantage
0
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Oakwood Products, Inc.
Tel
--
Fax
--
Email
sales@oakwoodchemical.com
Country
United States
ProdList
6193
Advantage
74
INDOFINE Chemical Company, Inc.
Tel
--
Fax
--
Email
chemical@indofinechemical.com
Country
United States
ProdList
6176
Advantage
69
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
APAC Pharmaceutical, LLC
Tel
--
Fax
--
Email
sales@apacpharma.com
Country
United States
ProdList
6322
Advantage
38
Aagile Labs Division of Tyger Scientific
Tel
--
Fax
--
Email
tygersci@yahoo.com
Country
United States
ProdList
6568
Advantage
68
Wilshire Chemical Company Inc.
Tel
--
Fax
--
Email
WilshrChem@AOL.COM
Country
United States
ProdList
3498
Advantage
58
ChemPacific Corporation
Tel
--
Fax
--
Email
sales@chempacific.com
Country
United States
ProdList
6891
Advantage
51
TimTec Corporation
Tel
--
Fax
--
Email
info@timtec.net
Country
United States
ProdList
6891
Advantage
68
Ven Petrochem & Pharma (India) Pvt.Ltd
Tel
--
Fax
--
Country
United States
ProdList
13
Advantage
52
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
AB Chem Technologies, LLC
Tel
--
Fax
--
Email
sales@abchemtech.com
Country
United States
ProdList
1101
Advantage
46
BOSCHE SCIENTIFIC, LLC
Tel
--
Fax
--
Email
Sales@BoscheSci.com
Country
United States
ProdList
6477
Advantage
55
CGeneTech, Inc.
Tel
--
Fax
--
Email
qyu@cgenetech.com
Country
United States
ProdList
959
Advantage
30
Aagami, Inc.
Tel
--
Fax
--
Email
dinesh@aagami.net
Country
United States
ProdList
557
Advantage
42
American Custom Chemicals Corporation
Tel
--
Fax
--
Email
sales@acccorporation.com
Country
United States
ProdList
6820
Advantage
51
More
Less

View Lastest Price from 2-Amino-5-methyl-3-thiophenecarbonitrile manufacturers

R&D Scientific Inc.
Product
2-Amino-5-methylthiophene-3-carbonitrile 138564-58-6
Price
US $790.00/g
Min. Order
1g
Purity
97
Supply Ability
500 Kg
Release date
2024-02-19
Honest Joy Holdings Limited
Product
2-Amino-5-methylthiophene-3-carbonitrile 138564-58-6
Price
US $0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
100 tons
Release date
2022-01-26
Qiuxian Baitai New Material Co., LTD
Product
2-amino-3-cyano-5-methylthiophene 138564-58-6
Price
US $2.00/g
Min. Order
1KG
Purity
99%
Supply Ability
5ton/Month
Release date
2021-12-21

138564-58-6, 2-Amino-5-methyl-3-thiophenecarbonitrileRelated Search:

Olanzapine Impurity K Olanzapine dimer 5-Methyl-2-[(2-nitrophenyl)amino]thiophene-3-carbonitrile Olanzapine ThioacetoxyMethylidene IMpurity Discontinued Olanzapine Impurity(ADP-2b) 4-Amino-2-methyl-10H-thiene[2,3-b][1,5]benzodiazepine hydrochloride IMp. A (EP): 5-Methyl-2-[(2-nitrophenyl)-aMino]thiophene-3-carbonitrile HydroxyMethylidene thione Olanzapine Benzoate Olanzapine Impurity(ADP-2c) 1-Fluoro-2-nitrobenzene 2-(1,2-PhenylenediaMino)-5-Methylthiphene-3-carbonitrile Olanzapine iMpurity (1-(5'-Methylthiophen-2'-yl)-1,3-dihydrobenzoiMidazol-2-one) 2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE 2-AMINO-6-METHYL-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE 2-AMINO-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHENE-3-CARBONITRILE Methyl 5-amino-4-cyano-3-methylthiophene-2-carboxylate 6-(DIMETHOXYMETHYL)-2-MERCAPTONICOTINONITRILE

  • 2-Amino-5-Methyl-3-Nitrothiophene
  • 2-Amino-5-methylthiopene-3-carbonitrile
  • 3-Thiophenecarbonitrile, 2-amino-5-methyl-
  • 2-Amino-5-methyl-3-t
  • 2-Amino-3-cyano-5-methyl
  • 3-Thiophenecarbonitrile,2-amino-5-methyl-(9CI)
  • TIMTEC-BB SBB000075
  • 2-AMINO-5-METHYL-3-CYANOTHIOPHENE
  • 2-AMINO-5-METHYL-3-THIOPHENECARBONITRILE
  • 2-AMINO-5-METHYLTHIOPEHNE-3-CARBONITRILE
  • 2-AMINO-5-METHYLTHIOPHENE-3-CARBONITRILE
  • 2-AMINO-3-CYANO-5-METHYLTHIOPHENE
  • Olanzapine Impurity 7
  • AKOS MSC-0403
  • Olanzapine Impurity 1
  • 2-Amino-5-m
  • Olanzapine Impurity 13
  • 2-Amino-5-methyl-3-thiophenecarbonitrile &gt
  • Olanzapine impurity BNB
  • Olanzapine impurity SA
  • 2-Amino-5-methyl-3-thiophenecarbonitrile ISO 9001：2015 REACH
  • Olanzapine ImpurityQ: What is Olanzapine Impurity Q: What is the CAS Number of Olanzapine Impurity Q: What is the storage condition of Olanzapine Impurity Q: What are the applications of Olanzapine Impurity
  • Olanzapine intermediates
  • 2-Amino -5methythiopene-3-carbonitrile
  • <font color="#ff0000">138564-58-6</font>
  • 2‐Amino‐5‐methylthiophene‐3‐ carbonitrile?(DN1)
  • 2-Amino-5-methyl-3-thiophenecarbonitrile, 10 mM in DMSO
  • 138564-58-6
  • 138654-58-6
  • 1632539-06-1
  • C6H6N2S
  • Aromatics, Heterocycles, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
  • Olanzapine
  • Heterocycle-oher series
  • Thiophene&Benzothiophene
  • Amines
  • (intermediate of olanzapine)
  • NITRILE
  • 138564-58-6
  • OLED