ChemicalBook > CAS DataBase List > diMethyl 5-broMopyridine-2,3-dicarboxylate

diMethyl 5-broMopyridine-2,3-dicarboxylate

Product Name: diMethyl 5-broMopyridine-2,3-dicarboxylate
CAS No.: 521980-82-5
Chemical Name: diMethyl 5-broMopyridine-2,3-dicarboxylate
Synonyms: DIMETHYL 5-BROMOPYRIDINE-2,3-D;dimethyl 5-bromopyridine-2,3-dicarboxylate - [D86883];2,3-Pyridinedicarboxylic acid, 5-bromo-, 2,3-dimethyl ester
CBNumber: CB32549627
Molecular Formula: C9H8BrNO4
Formula Weight: 274.07
MOL File: 521980-82-5.mol

Less

diMethyl 5-broMopyridine-2,3-dicarboxylate Property

Boiling point:: 315.0±37.0 °C(Predicted)
Density: 1.569±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: -3.18±0.10(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C9H8BrNO4/c1-14-8(12)6-3-5(10)4-11-7(6)9(13)15-2/h3-4H,1-2H3
InChIKey: JYRYOIMMYLBBNZ-UHFFFAOYSA-N
SMILES: C1(C(OC)=O)=NC=C(Br)C=C1C(OC)=O

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

AK Scientific

Product number: 7335AB
Product name: Dimethyl5-bromopyridine-2,3-dicarboxylate
Packaging: 250mg
Price: $317
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0360161
Product name: DIMETHYL-5-BROMOPYRIDINE-2,3-DICARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $501.28
Updated: 2021/12/16

AK Scientific

Product number: 7335AB
Product name: Dimethyl5-bromopyridine-2,3-dicarboxylate
Packaging: 1g
Price: $717
Updated: 2021/12/16

Chemenu

Product number: CM174055
Product name: dimethyl5-bromopyridine-2,3-dicarboxylate
Purity: 95%
Packaging: 10g
Price: $795
Updated: 2021/12/16

Crysdot

Product number: CD11111396
Product name: Dimethyl5-bromopyridine-2,3-dicarboxylate
Purity: 95+%
Packaging: 10g
Price: $850
Updated: 2021/12/16

Less

diMethyl 5-broMopyridine-2,3-dicarboxylate Chemical Properties,Usage,Production

Synthesis

67-56-1

89-00-9

521980-82-5

Concentrated sulfuric acid (10 mL) was slowly added to a methanolic (500 mL) suspension of 2,3-pyridinedicarboxylic acid (50 g, 300 mmol). The reaction mixture was heated to reflux for 48 hours and subsequently cooled to 40 °C and bromine (38 mL, 750 mmol) was added slowly and dropwise over 2 hours. The reaction mixture was continued to be heated at 55 °C for 48 h, followed by vacuum concentration. The concentrated residue was dissolved in isopropyl acetate (500 mL), and the resulting solution was washed sequentially with saturated aqueous sodium thiosulfate (200 mL x 4) and brine (400 mL), dried over anhydrous sodium sulfate, filtered, and concentrated again under vacuum. The residue was purified by silica gel column chromatography (petroleum ether/ethyl acetate, v/v=5/1) to afford dimethyl 5-bromo-pyridine-2,3-dicarboxylate as a yellow solid (52 g, 63% yield). Mass spectrum (ESI, positive ion mode) m/z: 274.0 [M + H]+; 1H NMR (400 MHz, CDCl3) δ (ppm): 8.75-8.76 (d, J = 2.2 Hz, 1H), 8.23-8.24 (d, J = 2.2 Hz, 1H), 3.93 (s, 3H), 3.89 (s, 3H).

References

[1] Patent: WO2014/89324, 2014, A1. Location in patent: Paragraph 0284
[2] Patent: CN104016979, 2017, B. Location in patent: Paragraph 0800; 0801; 0802; 0803
[3] Patent: US2012/122899, 2012, A1. Location in patent: Page/Page column 18
[4] Patent: WO2012/129013, 2012, A1. Location in patent: Page/Page column 29-30
[5] Patent: WO2013/169563, 2013, A1. Location in patent: Page/Page column 69; 70

diMethyl 5-broMopyridine-2,3-dicarboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

Less

diMethyl 5-broMopyridine-2,3-dicarboxylate Suppliers

China 66 India 2 United States 2 Global 70

Shanghai Huaxing Biological Technology Co., Ltd.

Tel: 18621295758
Fax: -QQ:1449085402
Email: 1449085402@qq.com
Country: China
ProdList: 1951
Advantage: 55

Tetranov Biopharm

Tel: 13526569071
Email: sales@leadmedpharm.com
Country: China
ProdList: 7892
Advantage: 64

Shanghai Boc Chemical Co.,Ltd

Tel: 021-34975603-808 18721111801
Fax: +86-21-34975602-805
Email: sales@bocpharma.com
Country: China
ProdList: 1009
Advantage: 64

Chengdu HappySyn Pharmaceutical Technology Co., Ltd.

Tel: 028-85114309 18982182443
Email: yangli@happysyn.com
Country: China
ProdList: 2151
Advantage: 55

SuZhou ShiYa Biopharmaceuticals, Inc.

Tel: 86(512)5235 8471 17715136450
Fax: 86(512)5235 6881
Email: sales@shiyabiopharm.com
Country: China
ProdList: 4169
Advantage: 58

Zhengzhou HSH Science & Technology Co., Ltd.

Tel: 0371-55932928 18937192232
Fax: 0086-0371-55932928
Email: 1282296214@qq.com
Country: China
ProdList: 498
Advantage: 55

AstaTech (Chengdu) Pharma. Co., Ltd.

Tel: 15928766785 15928766785
Fax: QQ961458712
Email: wupengcheng@astatech.cn
Country: China
ProdList: 1987
Advantage: 55

Shanghai Leto Pharmatech Co.,Ltd.

Tel: 18016401466
Fax: QQ: 1375988926
Email: sales@letopharm.com
Country: China
ProdList: 245
Advantage: 58

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

Zhengzhou AiXi Technology Co., Ltd.

Tel: 0371-56787280 13137706083
Fax: -
Email: m18539565376@163.com
Country: China
ProdList: 970
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

ChengDu TongChuangYuan Pharmaceutical Co.Ltd

Tel: 028-83379370 13880556291
Fax: 028-87747383
Email: tcy@tcypharm.com
Country: China
ProdList: 7218
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Yantai ShengKailun Chemical Technology Co., Ltd.

Tel: 13356901049
Fax: QQ：1025383091
Email: 3119594100@qq.com
Country: China
ProdList: 7964
Advantage: 55

Sichuan BaiPeng Biotechnology Co., Ltd.

Tel: 028-65791793 18140026355
Fax: QQ568470422
Email: 568470422@qq.com
Country: China
ProdList: 9997
Advantage: 58

Suzhou Baosheng Pharmaceutical Technology Co., Ltd.,

Tel: 18616776591
Fax: 021-54096319
Email: xuchenghao@sinch.com.cn
Country: China
ProdList: 205
Advantage: 58

Aikon International Limited

Tel: 025-58851090 15955137747
Fax: (6)02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 15949
Advantage: 58

Shanghai WangFa Chemical Technology Co., Ltd.

Tel: 13918479294
Fax: -
Email: xiebenfa@163.com
Country: China
ProdList: 4092
Advantage: 58

SHANGHAI FDC-CHEMICAL CO.,LTD

Tel: 021-61469567 13482353728
Fax: 021-61161605
Email: sales@fdc-chemical.com
Country: China
ProdList: 9722
Advantage: 58

Jinan Kabotang Biological Technology Co.,Ltd.

Tel: 0531-61320525 15866703830
Email: figo.gao@foxmail.com
Country: China
ProdList: 5177
Advantage: 58

SuZhou Medinoah Co.,LTD.

Tel: 0512-69561983 13914027025
Fax: 0512-69561982
Email: zhang_q@medinoah.com
Country: China
ProdList: 3811
Advantage: 58

Shaanxi Yikunte Pharmaceutical Technology Co., Ltd.

Tel: 18049260030 18049260030
Email: 380381031@qq.com
Country: China
ProdList: 500
Advantage: 58

Shandong utilizing biological technology co., LTD

Tel: 15966937598
Fax: 3407640895 3071519937
Email: 3407650895@qq.com
Country: China
ProdList: 2274
Advantage: 58

Beijing Bosennuokang Pharmaceutical Technology Co., Ltd.

Tel: 010-86203349 18201082367
Email: bosennuokang@163.com
Country: China
ProdList: 224
Advantage: 58

Chengdu Feibai Pharmaceutical Co., Ltd.

Tel: 028-84641798 18782128315
Email: 3302391190@qq.com
Country: China
ProdList: 9800
Advantage: 55

Suzhou Rovathin Foreign Trade Co.,Ltd

Tel: 0512-65816829 18662214788
Fax: 0512-65816829
Email: info@rovathin.com.cn
Country: China
ProdList: 9987
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418684 +8618949823763
Fax: 0086-551-65418684
Email: sales@tnjchem.com
Country: China
ProdList: 25356
Advantage: 58

Labnetwork lnc.

Tel: +86-27-50766799 +8618062016861
Email: contact@labnetwork.com
Country: China
ProdList: 19987
Advantage: 58

Wuxi Kehua Biological Technology Co., Ltd.

Tel: 0510-86838766 13636419861
Email: 2258830676@qq.com
Country: China
ProdList: 5044
Advantage: 58

Baimei Jihua (Henan) Pharmaceutical Technology Co., Ltd

Tel: 037188900765 18037465274
Fax: QQ3430974218
Email: enyawanglei@sina.cn
Country: China
ProdList: 13966
Advantage: 58

Shanghai Amico Chemicals Co. LTD

Tel: 微信 17321281695 18019252918
Fax: qq:1454668768
Email: 1454668768@qq.com
Country: China
ProdList: 14873
Advantage: 58

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Email: sales@accelachem.com
Country: China
ProdList: 10467
Advantage: 58

Chengdu Feibo Pharm Technology Co., Ltd

Tel: +86 028-84641798 15982321820
Email: abby@arkpharm.com
Country: China
ProdList: 10000
Advantage: 58

Qi Qi hang Biotechnology Co., Ltd.

Tel: 18151111370
Email: 1046215251@qq.com
Country: China
ProdList: 5999
Advantage: 58

Zhengzhou anmousse chemical products co. LTD

Tel: 0371-55289822 18737195735
Fax: QQ:483339295
Email: 483339295@qq.com
Country: China
ProdList: 7587
Advantage: 58

Shanghai Kaiwei Chemical Technology Co., Ltd.

Tel: 021-58461859 15821823057
Email: service@aiviche.com
Country: China
ProdList: 49312
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-29-87569266 +86-17392581500
Fax: 029-88380327
Email: 1015@dideu.com
Country: China
ProdList: 3987
Advantage: 58

Zhengzhou Convergence Chemical Co. LTD

Tel: 0371-0371-53736046 13393710386
Fax: QQ:2853979814
Email: 2853979814@qq.com
Country: China
ProdList: 9948
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Hubei Co-prosperity Medicine Technonlogy Co., Ltd

Tel: 2383948258 19172820304
Email: 2383948258@qq.com
Country: China
ProdList: 12987
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40000
Advantage: 58

Beijing Stronger Science Co., Ltd.

Tel: 0531-88924771 15614660963
Email: elsa.hang@strongerscience.com
Country: China
ProdList: 10623
Advantage: 58

PharmaBlock Sciences (Nanjing), Inc.

Tel: 4000255188
Fax: 025 86918232
Email: sales_china@pharmablock.com
Country: China
ProdList: 10000
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

Kaifeng Mingren Pharmaceutical Co.,LTD

Tel: 0371-65741762
Fax: QQ：2860768577
Email: sales@hasunny.com
Country: China
ProdList: 2380
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-6005915
Email: sales@picasso-e.com
Country: China
ProdList: 39653
Advantage: 58

Labnetwork lnc.

Tel: 13821353190
Email: qu_yanxia@labnetwork.com
Country: China
ProdList: 218
Advantage: 58

Shanghai Linuo Pharmaceutical Technology Co., LTD

Tel: 13486628501
Email: 3481904551@qq.com
Country: China
ProdList: 434
Advantage: 58

Jiaxing Zhejia Biotechnology Co., LTD

Tel: 0573-85609002 18367600069;
Email: zhejia01@163.com
Country: China
ProdList: 8887
Advantage: 58

Beijing InnoChem Science & Technology Co., Ltd.

Tel: 15652467323
Email: sales@inno-chem.com.cn
Country: China
ProdList: 8293
Advantage: 58

521980-82-5, diMethyl 5-broMopyridine-2,3-dicarboxylateRelated Search:

DIMETHYL 5-BROMOPYRIDINE-2,3-D

2,3-Pyridinedicarboxylic acid, 5-bromo-, 2,3-dimethyl ester

dimethyl 5-bromopyridine-2,3-dicarboxylate - [D86883]

521980-82-5