ChemicalBook > CAS DataBase List > 3-Fluoro-5-Methylanisole

3-Fluoro-5-Methylanisole

Product Name
3-Fluoro-5-Methylanisole
CAS No.
160911-11-5
Chemical Name
3-Fluoro-5-Methylanisole
Synonyms
5-Fluoro-3-methylanisole;3-Fluoro-5-Methylanisole;3-Fluoro-5-methoxytoluene;1-Fluoro-3-Methoxy-5-Methylbenzene;Benzene, 1-fluoro-3-methoxy-5-methyl-
CBNumber
CB32549809
Molecular Formula
C8H9FO
Formula Weight
140.15
MOL File
160911-11-5.mol
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3-Fluoro-5-Methylanisole Property

Boiling point:
164.2±20.0 °C(Predicted)
Density 
1.046±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
liquid
color 
Clear, Colourless
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Safety

HS Code 
2909309090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Apolloscientific
Product number
PC7519
Product name
3-Fluoro-5-methylanisole
Purity
99%
Packaging
1g
Price
$63
Updated
2021/12/16
SynQuest Laboratories
Product number
2707-3-10
Product name
3-Fluoro-5-methylanisole
Purity
99%
Packaging
1g
Price
$69
Updated
2021/12/16
Apolloscientific
Product number
PC7519
Product name
3-Fluoro-5-methylanisole
Purity
99%
Packaging
5g
Price
$185
Updated
2021/12/16
SynQuest Laboratories
Product number
2707-3-10
Product name
3-Fluoro-5-methylanisole
Purity
99%
Packaging
5G
Price
$204
Updated
2021/12/16
Ambeed
Product number
A117469
Product name
1-Fluoro-3-methoxy-5-methylbenzene
Purity
98%
Packaging
1g
Price
$37
Updated
2021/12/16
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3-Fluoro-5-Methylanisole Chemical Properties,Usage,Production

Uses

3-Fluoro-5-Methylanisole is utilized in various applications, including the production of pharmaceuticals, fragrances, and other fine chemicals.

Synthesis

823-96-1

29578-39-0

160911-11-5

General procedure for the synthesis of 1-fluoro-3-methoxy-5-methylbenzene from trimethylcyclotriboroxane and 3-bromo-5-fluoroanisole (Example 40): (40a) Synthesis of 1-fluoro-3-methoxy-5-methylbenzene 3-Bromo-5-fluoroanisole (2.05 g, 10 mmol), trimethylcyclotriboroxane (50% THF solution, 2.51 g, 20 mmol), PdCl2(dppf) (0.82 g, 1.0 mmol), and cesium carbonate (6.52 g, 20 mmol) were dissolved in a solvent mixture of dioxane (100 mL) and water (50 mL). It was heated and stirred under reflux conditions for 10 hours. Upon completion of the reaction, it was cooled to room temperature and water (100 mL) was added to the reaction solution, which was then extracted twice with ethyl acetate (200 mL). The organic layers were combined, washed twice with water (100 mL) and dried over anhydrous sodium sulfate. After concentration under reduced pressure, the residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate, 6:1) to afford 1-fluoro-3-methoxy-5-methylbenzene (1.40 g, yield: 66%) as a yellow oil. 1H-NMR (CDCl3, 400 MHz) δ: 1.78 (3H, s), 6.44 (1H, dd, J = 2.0, 11.0 Hz), 6.50 (1H, d, J = 11.0 Hz), 6.51 (1H, s).

References

[1] Patent: EP2138484, 2009, A1. Location in patent: Page/Page column 44

3-Fluoro-5-Methylanisole Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Fluoro-5-Methylanisole Suppliers

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160911-11-5, 3-Fluoro-5-MethylanisoleRelated Search:


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  • 160911-11-5