1-Chloro-2-fluoro-4-Methoxy-5-nitrobenzene
Uses- Product Name
- 1-Chloro-2-fluoro-4-Methoxy-5-nitrobenzene
- CAS No.
- 1089280-66-9
- Chemical Name
- 1-Chloro-2-fluoro-4-Methoxy-5-nitrobenzene
- Synonyms
- 1-Chloro-2-fluoro-4-Methoxy-5-nitrobenzene;1-chlorine-4-fluorine-5-methoxynitrobenzene;Benzene, 1-chloro-2-fluoro-4-methoxy-5-nitro-
- CBNumber
- CB32550359
- Molecular Formula
- C7H5ClFNO3
- Formula Weight
- 205.57
- MOL File
- 1089280-66-9.mol
1-Chloro-2-fluoro-4-Methoxy-5-nitrobenzene Property
- Boiling point:
- 273.3±35.0 °C(Predicted)
- Density
- 1.453±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
N-Bromosuccinimide Price
- Product number
- CS-0042593
- Product name
- 1-Chloro-2-fluoro-4-methoxy-5-nitrobenzene
- Packaging
- 1g
- Price
- $133
- Updated
- 2021/12/16
- Product number
- PC50377
- Product name
- 1-Chloro-2-fluoro-4-methoxy-5-nitrobenzene
- Packaging
- 1g
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 8490DK
- Product name
- 1-Chloro-2-fluoro-4-methoxy-5-nitrobenzene
- Packaging
- 1g
- Price
- $239
- Updated
- 2021/12/16
- Product number
- HCH0050280
- Product name
- 1-CHLORO-2-FLUORO-4-METHOXY-5-NITROBENZENE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.99
- Updated
- 2021/12/16
- Product number
- A133987
- Product name
- 1-Chloro-2-fluoro-4-methoxy-5-nitrobenzene
- Purity
- 97%
- Packaging
- 250mg
- Price
- $44
- Updated
- 2021/12/16
1-Chloro-2-fluoro-4-Methoxy-5-nitrobenzene Chemical Properties,Usage,Production
Uses
1-Chloro-2-fluoro-4-methoxy-5-nitrobenzene is a hydrocarbon derivative, mainly used as a pharmaceutical intermediate.
Synthesis
501-29-1
1089280-66-9
General procedure for the synthesis of 1-chloro-2-fluoro-4-methoxy-5-nitrobenzene from 4-chloro-3-fluoroanisole: To a concentrated mixture of 1-chloro-2-fluoro-4-methoxybenzene (5.00 g, 31.1 mmol), concentrated H2SO4 (30 mL) was slowly added at 0-10 °C. Potassium nitrate (3.78 g, 37.4 mmol) was then added in batches and the reaction mixture was kept stirred at 0 °C for 2 hours. Upon completion of the reaction, the reaction was quenched with ice water and the solid product was collected by filtration. The resulting solid was purified by recrystallization from hexane to afford 4.50 g (70% yield) of the target compound 1-chloro-2-fluoro-4-methoxy-5-nitrobenzene. The structure of the product was confirmed by 1HNMR (400 MHz, DMSO-d6): δ 8.30 (d, J=2.0 Hz, 1H), 7.61 (d, J=2.3 Hz, 1H), 3.96 (s, 3H); ESI-MS (m/z) 205.76 (MH)+.
References
[1] Patent: WO2014/22349, 2014, A1. Location in patent: Paragraph 00194
[2] Patent: WO2018/20474, 2018, A1. Location in patent: Page/Page column 155
1-Chloro-2-fluoro-4-Methoxy-5-nitrobenzene Preparation Products And Raw materials
Raw materials
Preparation Products
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