952511-48-7 5-broMo-4-Methyl-1H-benzo[d]iMidazole

952511-48-7 5-broMo-4-Methyl-1H-benzo[d]iMidazole Property

Boiling point:

418.3±25.0 °C(Predicted)

Density 

1.654±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

11.60±0.30(Predicted)

Appearance

Yellow to brown Solid

Safety

HS Code 

2933998090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

952511-48-7 5-broMo-4-Methyl-1H-benzo[d]iMidazole Chemical Properties,Usage,Production

Synthesis

3. A mixture of 4-bromo-3-methylbenzene-1,2-diamine (28 g, 140 mmol), formic acid (240 mL), and 37% hydrochloric acid (400 mL) was heated to 60 °C and held for 12 h. The reaction was completed by filtration. Upon completion of the reaction, the mixture was cooled in an ice-water bath and the pH was slowly adjusted to 8-9 with 28% ammonia. the resulting solid was collected by filtration, washed with water, and dried in air to afford 5-bromo-4-methyl-1H-benzo[d]imidazole (25 g, 98% yield) as a yellow solid. Mass spectrum (ESI) m/z = 213 [M + 1]+.

References

[1] Patent: WO2013/26914, 2013, A1. Location in patent: Page/Page column 143
[2] Patent: US2010/222345, 2010, A1. Location in patent: Page/Page column 87