tert-butyl 1-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutylcarbaMate

Product Name: tert-butyl 1-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutylcarbaMate
CAS No.: 1032528-06-5
Chemical Name: tert-butyl 1-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutylcarbaMate
Synonyms: 4-[(1-BOC-Amino)cyclobutyl]phenylboronic acid pinacol ester;tert-Butyl (1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl);tert-butyl N-{1-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclobutyl}carbamate;tert-butyl 1-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutylcarbaMate;Tert-butyl N-[1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclobutyl]carbamate;tert-Butyl 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutylcarbamate - [B15613];[1-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]cyclobutyl]carbamic acid tert-butyl ester;N-[1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclobutyl]Carbamic acid 1,1-dimethylethyl ester;CarbaMic acid, N-[1-[4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclobutyl]-, 1,1-diMethylethyl ester
CBNumber: CB32553451
Molecular Formula: C21H32BNO4
Formula Weight: 373.29
MOL File: 1032528-06-5.mol

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tert-butyl 1-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutylcarbaMate Property

Boiling point:: 481.0±34.0 °C(Predicted)
Density: 1.08
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 11.98±0.20(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B710053
Product name: tert-Butyl(1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutyl)carbamate
Packaging: 50mg
Price: $130
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BOR0007361
Product name: TERT-BUTYL-(1-(4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL)CYCLOBUTYL)CARBAMATE
Purity: 95.00%
Packaging: 1G
Price: $1068.9
Updated: 2021/12/16

Matrix Scientific

Product number: 090913
Product name: tert-Butyl (1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxabo-rolan-2-yl)phenyl)cyclobutyl)carbamate
Purity: 95+%
Packaging: 1g
Price: $1311
Updated: 2021/12/16

Synthonix

Product number: B15613
Product name: tert-Butyl1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutylcarbamate
Purity: 95+%
Packaging: 5g
Price: $1550
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BOR0007361
Product name: TERT-BUTYL-(1-(4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL)CYCLOBUTYL)CARBAMATE
Purity: 95.00%
Packaging: 5MG
Price: $497.41
Updated: 2021/12/16

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tert-butyl 1-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutylcarbaMate Chemical Properties,Usage,Production

Synthesis

1032350-06-3

73183-34-3

1032528-06-5

Step 5: In 500 mL of degassed tetrahydrofuran (THF), 27.75 g (55 mmol) of tert-butyl 1-(4-bromophenyl) cyclobutylcarbamate, 23.76 g (93.6 mmol) of pinacol ester of bis(boronic acid), 25 g (255 mmol) of potassium acetate, and 2.08 g (2.55 mmol) of 1,1 '-bis(diphenylphosphino) ferrocene palladium(II) dichloride. The reaction mixture was heated to reflux for 3 h. The color of the reaction mixture was observed to change from dark red to black. Due to incomplete reaction, heating was continued for 2 hours. Upon completion of the reaction, the reaction mixture was poured into 400 mL of water and diluted with 700 mL of ethyl acetate. After stirring for 30 minutes, the organic phase was separated and the aqueous phase was extracted twice more with 400 mL and 200 mL of ethyl acetate, respectively. The organic extracts were combined, washed with 200 mL of brine and dried with sodium sulfate. After evaporation of the solvent, the residue was purified by Biotage chromatography to afford 28.99 g (91.3% yield) of tert-butyl 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutylcarbamate.1H NMR (400 MHz, DMSO-d6)δ: 7.51-7.67 (m, 3H), 7.38 (d, 2H), 2.22-2.42 (m, 4H), 1.88-2.02 (m, 1H), 1.63-1.80 (m, 1H), 1.00-1.38 (m, 21H) ppm.

References

[1] Patent: WO2013/104611, 2013, A1. Location in patent: Page/Page column 48
[2] Patent: WO2012/7416, 2012, A1. Location in patent: Page/Page column 75; 76
[3] Patent: US2014/5185, 2014, A1. Location in patent: Paragraph 0256-0258
[4] Patent: EP2868660, 2015, A1. Location in patent: Paragraph 0172
[5] Patent: WO2012/7345, 2012, A2. Location in patent: Page/Page column 243

tert-butyl 1-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutylcarbaMate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-butyl 1-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutylcarbaMate Suppliers

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1032528-06-5, tert-butyl 1-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutylcarbaMateRelated Search:

dimethylsilanediol

tert-butyl 1-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutylcarbaMate

[1-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]cyclobutyl]carbamic acid tert-butyl ester

CarbaMic acid, N-[1-[4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclobutyl]-, 1,1-diMethylethyl ester

N-[1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclobutyl]Carbamic acid 1,1-dimethylethyl ester

tert-Butyl (1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)

tert-butyl N-{1-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclobutyl}carbamate

Tert-butyl N-[1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclobutyl]carbamate

4-[(1-BOC-Amino)cyclobutyl]phenylboronic acid pinacol ester

tert-Butyl 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutylcarbamate - [B15613]

1032528-06-5