4-broMo-2-isopropoxypyridine
- Product Name
- 4-broMo-2-isopropoxypyridine
- CAS No.
- 1142194-24-8
- Chemical Name
- 4-broMo-2-isopropoxypyridine
- Synonyms
- 4-broMo-2-isopropoxypyridine;4-bromo-2-(prop-2-yloxy)pyridine;Pyridine, 4-bromo-2-(1-methylethoxy)-
- CBNumber
- CB32553714
- Molecular Formula
- C8H10BrNO
- Formula Weight
- 216.08
- MOL File
- 1142194-24-8.mol
4-broMo-2-isopropoxypyridine Property
- Boiling point:
- 232.8±20.0 °C(Predicted)
- Density
- 1.383±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 4.99±0.10(Predicted)
- form
- liquid
- color
- Colourless
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B810963
- Product name
- 4-Bromo-2-isopropoxypyridine
- Packaging
- 100mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 5151AQ
- Product name
- 4-bromo-2-propan-2-yloxypyridine
- Packaging
- 1g
- Price
- $320
- Updated
- 2021/12/16
- Product number
- HCH0365616
- Product name
- 4-BROMO-2-ISOPROPOXYPYRIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.84
- Updated
- 2021/12/16
- Product number
- BB20-6324
- Product name
- 4-Bromo-2-isopropoxy-pyridine
- Purity
- >95%
- Packaging
- 1g
- Price
- $180
- Updated
- 2021/12/16
- Product number
- CM174852
- Product name
- 4-Bromo-2-isopropoxypyridine
- Purity
- 95%
- Packaging
- 5g
- Price
- $533
- Updated
- 2021/12/16
4-broMo-2-isopropoxypyridine Chemical Properties,Usage,Production
Synthesis
128071-98-7
67-63-0
1142194-24-8
Example 15: Synthesis of 3-methoxy-1-(2-(4-(4-[4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]-3,6-dihydro-2H-pyridin-1-yl)-2-oxoethyl)pyrrolidine-2-carboxylic acid [3-(2-isopropoxypyridin-4-yl)-1H-indazol-5-yl]amide Step 1: Preparation of 4-bromo-2-isopropoxypyridine Anhydrous isopropanol (50 mL) solution of 4-bromo-2-fluoropyridine (4.12 g, 23.41 mmol) followed by potassium tert-butoxide (2.627 g, 23.41 mmol) was added to a 150 mL pressure vessel under nitrogen protection. The pressure vessel was sealed and the reaction was heated at 80 °C for 3 hours. After completion of the reaction, the pressure vessel was cooled to 0 °C in an ice bath. The reaction mixture was transferred to a 250 mL round bottom flask and concentrated to a small volume. The concentrated mixture was partitioned between ethyl acetate and water. The organic phase was separated, washed with saturated sodium chloride solution and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give a clarified oil. Purification by RediSep 80 g silica gel column chromatography with 20:1 hexane/ethyl acetate as eluent gave the clarified oily product 4-bromo-2-isopropoxypyridine (4.2 g, 83%).
References
[1] Patent: WO2009/105500, 2009, A1. Location in patent: Page/Page column 274
[2] Patent: WO2015/42397, 2015, A1. Location in patent: Paragraph 000652
4-broMo-2-isopropoxypyridine Preparation Products And Raw materials
Raw materials
Preparation Products
4-broMo-2-isopropoxypyridine Suppliers
- Tel
- 13526569071
- sales@leadmedpharm.com
- Country
- China
- ProdList
- 7892
- Advantage
- 64
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- 86(512)5235 8471 17715136450
- Fax
- 86(512)5235 6881
- sales@shiyabiopharm.com
- Country
- China
- ProdList
- 4169
- Advantage
- 58
- Tel
- 13812573443
- Fax
- -
- tongbenwan22@163.com
- Country
- China
- ProdList
- 1980
- Advantage
- 55
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 021-20432229
- Fax
- QQ2412110556
- 2412110556@qq.com
- Country
- China
- ProdList
- 6017
- Advantage
- 55
- Tel
- 025-87782433 18021532344
- Fax
- 025-87782433
- 1345332203@qq.com
- Country
- China
- ProdList
- 4134
- Advantage
- 58
- Tel
- 021-021-021-31663258 13795219287
- Fax
- 021-31663258
- donghuanwen@126.com
- Country
- China
- ProdList
- 8816
- Advantage
- 58
- Tel
- 021-65232103 17602124823
- combiphos@vip.qq.com
- Country
- China
- ProdList
- 30000
- Advantage
- 58
- Tel
- 022-59987777 13552403979
- jia_guoqiang@wuxiapptec.com
- Country
- China
- ProdList
- 22345
- Advantage
- 58
- Tel
- 025-58859352 18068836627
- Fax
- 02557626880
- sales01@aikonchem.com
- Country
- China
- ProdList
- 16027
- Advantage
- 58
- Tel
- 15026866316
- 180642609@qq.com
- Country
- China
- ProdList
- 4967
- Advantage
- 58
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52687
- Advantage
- 58
- Tel
- +86-25-58393656
- Fax
- +86-25-58393656
- sales@hengbeichem.cn
- Country
- China
- ProdList
- 6854
- Advantage
- 58
- Tel
- 13674959855 13674959855
- sales@synthontech.com
- Country
- China
- ProdList
- 3035
- Advantage
- 58
- Tel
- 0519-68985668 13685222090
- Fax
- qq735434464
- sales@kechem.cn
- Country
- China
- ProdList
- 26028
- Advantage
- 58
- Tel
- 13000000000
- jnxinhongtai@126.com
- Country
- China
- ProdList
- 19528
- Advantage
- 58
- Tel
- 15895968936
- Fax
- qq 1018762393
- 1018762393@qq.com
- Country
- China
- ProdList
- 9999
- Advantage
- 58
- Tel
- 400-8210725 4008210725
- malulu@leyan.com
- Country
- China
- ProdList
- 40000
- Advantage
- 58
- Tel
- 400-6005915
- sales@picasso-e.com
- Country
- China
- ProdList
- 39653
- Advantage
- 58
- Tel
- 15652467323
- sales@inno-chem.com.cn
- Country
- China
- ProdList
- 8293
- Advantage
- 58
- Tel
- 0371-53370800 18037197114
- 2853031799@qq.com
- Country
- China
- ProdList
- 9892
- Advantage
- 58
- Tel
- 3456065315 13260619011
- 3456065315@qq.com
- Country
- China
- ProdList
- 2199
- Advantage
- 58
- Tel
- 13356901049
- mark@sklnchem.cn
- Country
- China
- ProdList
- 7998
- Advantage
- 58
- Tel
- 18455579438
- Country
- China
- ProdList
- 16684
- Advantage
- 58
- Tel
- 010-50973130 17801761073
- Gsiyu@solarbio.com
- Country
- China
- ProdList
- 50464
- Advantage
- 58
- Tel
- 021-57520305 13795461237
- zhuruyan@jskchem.com
- Country
- China
- ProdList
- 49234
- Advantage
- 58
- Tel
- 400-0628126 15697567703
- sales-team@aobchem.com.cn
- Country
- China
- ProdList
- 49999
- Advantage
- 58
- Tel
- 021-54306202 18917919676
- info@hanhongsci.com
- Country
- China
- ProdList
- 29995
- Advantage
- 58
- Tel
- 0635-893290 18663513896;
- 28698871@qq.com
- Country
- China
- ProdList
- 8022
- Advantage
- 58
- Tel
- 400-6206333 13167063860
- anhua.mao@aladdin-e.com
- Country
- China
- ProdList
- 48457
- Advantage
- 58
- Tel
- 86-13349903920 13349903920
- Fax
- -
- 869523959@qq.com
- Country
- China
- ProdList
- 9627
- Advantage
- 58
- Tel
- 029-81136151 17392212881
- 1095@dideu.com
- Country
- China
- ProdList
- 10001
- Advantage
- 58
- Tel
- 17717618050
- zllg@gh-reagent.com
- Country
- China
- ProdList
- 10420
- Advantage
- 58
- Tel
- 25-57027686 17372956142
- li_lan@syntitan.com
- Country
- China
- ProdList
- 5807
- Advantage
- 58
- Tel
- 17715136450
- 2439673774@qq.com
- Country
- China
- ProdList
- 15647
- Advantage
- 58
- Tel
- 18987584767
- Country
- CHINA
- ProdList
- 165
- Advantage
- 58