1H-IMidazo[4,5-b]pyridine-6-carboxylic acid, Methyl ester

Product Name: 1H-IMidazo[4,5-b]pyridine-6-carboxylic acid, Methyl ester
CAS No.: 77862-95-4
Chemical Name: 1H-IMidazo[4,5-b]pyridine-6-carboxylic acid, Methyl ester
Synonyms: ethyl 3H-imidazo[4,5-b]pyridine-6-carboxylate;Methyl 1H-iMidazo[4,5-b]pyridine-6-carboxylate;3H-Imidazo[4,5-b]pyridine-6-carboxylic acid, methyl ester;1H-IMidazo[4,5-b]pyridine-6-carboxylic acid, Methyl ester
CBNumber: CB32553901
Molecular Formula: C8H7N3O2
Formula Weight: 177.16
MOL File: 77862-95-4.mol

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1H-IMidazo[4,5-b]pyridine-6-carboxylic acid, Methyl ester Property

storage temp.: 2-8°C
Appearance: White to yellow Solid

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: M643405
Product name: Methyl1H-imidazo[4,5-b]pyridine-6-carboxylate
Packaging: 50mg
Price: $220
Updated: 2021/12/16

AK Scientific

Product number: 2208AC
Product name: Methyl1H-imidazo[4,5-b]pyridine-6-carboxylate
Packaging: 250mg
Price: $504
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0392797
Product name: METHYL-1H-IMIDAZO[4,5-B]PYRIDINE-6-CARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $504.17
Updated: 2021/12/16

Apolloscientific

Product number: OR305190
Product name: Methyl1H-imidazo[4,5-b]pyridine-6-carboxylate
Packaging: 250mg
Price: $522
Updated: 2021/12/16

Alichem

Product number: 77862954
Product name: Methyl1H-imidazo[4,5-b]pyridine-6-carboxylate
Packaging: 250mg
Price: $197.4
Updated: 2021/12/16

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1H-IMidazo[4,5-b]pyridine-6-carboxylic acid, Methyl ester Chemical Properties,Usage,Production

Synthesis

64-18-6

104685-76-9

77862-95-4

Step 2: A mixed solution of methyl 5,6-diaminonicotinate (1.69 g, 10.12 mmol), formic acid (0.5 mL) and triethyl orthoformate (25 mL) prepared in Step 1 was stirred and reacted at 90 °C for 2.5 hours. After completion of the reaction, the mixture was cooled to room temperature, and the precipitated solid was collected by filtration and dried to afford methyl 3H-imidazo[4,5-b]pyridine-6-carboxylate (588 mg, 33% yield) as a milky white solid, which did not require further purification. The filtrate was concentrated under reduced pressure and the residue was purified by fast column chromatography on silica gel with gradient elution from dichloromethane to dichloromethane solution containing 10% methanol as eluent to afford additional methyl 3H-imidazo[4,5-b]pyridine-6-carboxylate (550 mg, 31% yield) as a cream colored solid. The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6) δ 13.33 (br s, 1H), 8.95 (d, J = 1.5 Hz, 1H), 8.64 (s, 1H), 8.50 (d, J = 1.5 Hz, 1H), 3.91 (s, 3H) and LCMS (ESI) m/z 178 (M + H)+.

References

[1] Patent: EP2766359, 2016, B1. Location in patent: Paragraph 0585

1H-IMidazo[4,5-b]pyridine-6-carboxylic acid, Methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-IMidazo[4,5-b]pyridine-6-carboxylic acid, Methyl ester Suppliers

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77862-95-4, 1H-IMidazo[4,5-b]pyridine-6-carboxylic acid, Methyl esterRelated Search:

1H-IMidazo[4,5-b]pyridine-6-carboxylic acid, Methyl ester

Methyl 1H-iMidazo[4,5-b]pyridine-6-carboxylate

ethyl 3H-imidazo[4,5-b]pyridine-6-carboxylate

3H-Imidazo[4,5-b]pyridine-6-carboxylic acid, methyl ester

77862-95-4