1H-IMidazo[4,5-b]pyridine-6-carboxylic acid, Methyl ester
- Product Name
- 1H-IMidazo[4,5-b]pyridine-6-carboxylic acid, Methyl ester
- CAS No.
- 77862-95-4
- Chemical Name
- 1H-IMidazo[4,5-b]pyridine-6-carboxylic acid, Methyl ester
- Synonyms
- ethyl 3H-imidazo[4,5-b]pyridine-6-carboxylate;Methyl 1H-iMidazo[4,5-b]pyridine-6-carboxylate;3H-Imidazo[4,5-b]pyridine-6-carboxylic acid, methyl ester;1H-IMidazo[4,5-b]pyridine-6-carboxylic acid, Methyl ester
- CBNumber
- CB32553901
- Molecular Formula
- C8H7N3O2
- Formula Weight
- 177.16
- MOL File
- 77862-95-4.mol
1H-IMidazo[4,5-b]pyridine-6-carboxylic acid, Methyl ester Property
- storage temp.
- 2-8°C
- Appearance
- White to yellow Solid
Safety
- HS Code
- 2933399990
N-Bromosuccinimide Price
- Product number
- M643405
- Product name
- Methyl1H-imidazo[4,5-b]pyridine-6-carboxylate
- Packaging
- 50mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- 2208AC
- Product name
- Methyl1H-imidazo[4,5-b]pyridine-6-carboxylate
- Packaging
- 250mg
- Price
- $504
- Updated
- 2021/12/16
- Product number
- CHM0392797
- Product name
- METHYL-1H-IMIDAZO[4,5-B]PYRIDINE-6-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.17
- Updated
- 2021/12/16
- Product number
- OR305190
- Product name
- Methyl1H-imidazo[4,5-b]pyridine-6-carboxylate
- Packaging
- 250mg
- Price
- $522
- Updated
- 2021/12/16
- Product number
- 77862954
- Product name
- Methyl1H-imidazo[4,5-b]pyridine-6-carboxylate
- Packaging
- 250mg
- Price
- $197.4
- Updated
- 2021/12/16
1H-IMidazo[4,5-b]pyridine-6-carboxylic acid, Methyl ester Chemical Properties,Usage,Production
Synthesis
64-18-6
104685-76-9
77862-95-4
Step 2: A mixed solution of methyl 5,6-diaminonicotinate (1.69 g, 10.12 mmol), formic acid (0.5 mL) and triethyl orthoformate (25 mL) prepared in Step 1 was stirred and reacted at 90 °C for 2.5 hours. After completion of the reaction, the mixture was cooled to room temperature, and the precipitated solid was collected by filtration and dried to afford methyl 3H-imidazo[4,5-b]pyridine-6-carboxylate (588 mg, 33% yield) as a milky white solid, which did not require further purification. The filtrate was concentrated under reduced pressure and the residue was purified by fast column chromatography on silica gel with gradient elution from dichloromethane to dichloromethane solution containing 10% methanol as eluent to afford additional methyl 3H-imidazo[4,5-b]pyridine-6-carboxylate (550 mg, 31% yield) as a cream colored solid. The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6) δ 13.33 (br s, 1H), 8.95 (d, J = 1.5 Hz, 1H), 8.64 (s, 1H), 8.50 (d, J = 1.5 Hz, 1H), 3.91 (s, 3H) and LCMS (ESI) m/z 178 (M + H)+.
References
[1] Patent: EP2766359, 2016, B1. Location in patent: Paragraph 0585
1H-IMidazo[4,5-b]pyridine-6-carboxylic acid, Methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
1H-IMidazo[4,5-b]pyridine-6-carboxylic acid, Methyl ester Suppliers
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