2-Formyl-5-(trifluoromethyl)phenol, 4-Formyl-3-hydroxybenzotrifluoride, 4-(Trifluoromethyl)salicylaldehyde

Product Name: 2-Formyl-5-(trifluoromethyl)phenol, 4-Formyl-3-hydroxybenzotrifluoride, 4-(Trifluoromethyl)salicylaldehyde
CAS No.: 58914-34-4
Chemical Name: 2-Formyl-5-(trifluoromethyl)phenol, 4-Formyl-3-hydroxybenzotrifluoride, 4-(Trifluoromethyl)salicylaldehyde
Synonyms: 2-Hydroxy-4-(trifluoromethyl);4-trifluoromethylsalicaldehyde;4-Trifluoromethylsalicyaldehyde;4-(Trifluoromethyl)salicylaldehyde;4-Formyl-3-hydroxybenzotrifluoride;2-Formyl-5-(trifluoromethyl)phenol;2-Hydroxy-4-(tifluoromethyl)benzaldehyde;2-Hydroxy-4-(trifluoromethyl)benzaldehyde;Benzaldehyde, 2-hydroxy-4-(trifluoromethyl)-;2-Hydroxy-4-(trifluoromethyl)benzaldehyde97%
CBNumber: CB32560716
Molecular Formula: C8H5F3O2
Formula Weight: 190.12
MOL File: 58914-34-4.mol

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2-Formyl-5-(trifluoromethyl)phenol, 4-Formyl-3-hydroxybenzotrifluoride, 4-(Trifluoromethyl)salicylaldehyde Property

Boiling point:: 217.8±40.0 °C(Predicted)
Density: 1.429±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 7.17±0.10(Predicted)
color: Colourless to Pale Yellow

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Safety

HS Code: 2912210000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: H876790
Product name: 2-Hydroxy-4-(trifluoromethyl)benzaldehyde
Packaging: 100mg
Price: $40
Updated: 2021/12/16

ChemScene

Product number: CS-0051895
Product name: 2-Hydroxy-4-(trifluoromethyl)benzaldehyde
Purity: 99.90%
Packaging: 250mg
Price: $57
Updated: 2021/12/16

ChemScene

Product number: CS-0051895
Product name: 2-Hydroxy-4-(trifluoromethyl)benzaldehyde
Purity: 99.90%
Packaging: 1g
Price: $113
Updated: 2021/12/16

AK Scientific

Product number: 2087AL
Product name: 2-Hydroxy-4-(trifluoromethyl)benzaldehyde
Packaging: 1g
Price: $150
Updated: 2021/12/16

Apolloscientific

Product number: PC51027
Product name: 2-Hydroxy-4-(trifluoromethyl)benzaldehyde
Purity: 97%
Packaging: 1g
Price: $290
Updated: 2021/12/16

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2-Formyl-5-(trifluoromethyl)phenol, 4-Formyl-3-hydroxybenzotrifluoride, 4-(Trifluoromethyl)salicylaldehyde Chemical Properties,Usage,Production

Uses

2-Hydroxy-4-(trifluoromethyl)benzaldehyde (cas# 58914-34-4) is used as a reactant in the preparation of flavone derivatives for the treatment and prophylaxis of hepatitis B virus disease.

Synthesis

89763-93-9

58914-34-4

Step 2: Synthesis of 2-hydroxy-4-(trifluoromethyl)benzaldehyde 2-Fluoro-4-(trifluoromethyl)benzaldehyde (5.00 g, 26.0 mmol, 1.00 equiv), water (5 mL), potassium carbonate (10.8 g, 78.1 mmol, 3.00 equiv), and DMSO (50 mL) were added to a reaction flask under nitrogen protection. The reaction mixture was stirred at 100 °C overnight. Upon completion of the reaction, the reaction was quenched with deionized water (70 mL). The reaction mixture was extracted with dichloromethane (3 x 100 mL), the organic phases were combined, washed with saturated saline (200 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with the eluent of ethyl acetate/petroleum ether (6/94, v/v) to give 3.07 g of 2-hydroxy-4-(trifluoromethyl)benzaldehyde in 62% yield as a yellow oil.

References

[1] Patent: WO2017/197192, 2017, A1. Location in patent: Paragraph 00401
[2] Patent: US2018/134674, 2018, A1. Location in patent: Paragraph 0327; 0328
[3] Patent: WO2018/93949, 2018, A1. Location in patent: Paragraph 00287
[4] Patent: WO2017/87854, 2017, A1. Location in patent: Paragraph 00264

2-Formyl-5-(trifluoromethyl)phenol, 4-Formyl-3-hydroxybenzotrifluoride, 4-(Trifluoromethyl)salicylaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Formyl-5-(trifluoromethyl)phenol, 4-Formyl-3-hydroxybenzotrifluoride, 4-(Trifluoromethyl)salicylaldehyde Suppliers

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58914-34-4, 2-Formyl-5-(trifluoromethyl)phenol, 4-Formyl-3-hydroxybenzotrifluoride, 4-(Trifluoromethyl)salicylaldehydeRelated Search:

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