ChemicalBook > CAS DataBase List > PF 4800567 hydrochloride

PF 4800567 hydrochloride

Product Name: PF 4800567 hydrochloride
CAS No.: 1188296-52-7
Chemical Name: PF 4800567 hydrochloride
Synonyms: PF 4800567;PF 4800567;PF-4800567;PF 4800567 hydrochloride;PF-4800567, 10 mM in DMSO;Casein Kinase I Inhibitor III, PF-4800567;Casein Kinase,PF4800567,inhibit,PF-4800567,PF 4800567,Inhibitor;3-[(3-chlorophenoxy)methyl]-1-(oxan-4-yl)pyrazolo[3,4-d]pyrimidin-4-amine;3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-[(3-chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-;3-[(3-Chlorophenoxy)Methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine Hydrochloride
CBNumber: CB32561076
Molecular Formula: C17H18ClN5O2
Formula Weight: 359.81
MOL File: 1188296-52-7.mol

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PF 4800567 hydrochloride Property

Boiling point:: 592.9±50.0 °C(Predicted)
Density: 1.52±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: DMF: 25 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 10 mg/ml; Ethanol: 1 mg/ml
form: A crystalline solid
pka: 4.01±0.30(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 218719
Product name: Casein Kinase I Inhibitor III, PF-4800567
Purity: The Casein Kinase I Inhibitor III, PF-4800567 controls the biological activity of Casein Kinase I. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applicat
Packaging: 5 mg
Price: $303
Updated: 2025/07/31

Cayman Chemical

Product number: 19171
Product name: PF-4800567
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 19171
Product name: PF-4800567
Purity: ≥98%
Packaging: 5mg
Price: $142
Updated: 2024/03/01

Cayman Chemical

Product number: 19171
Product name: PF-4800567
Purity: ≥98%
Packaging: 10mg
Price: $231
Updated: 2024/03/01

Cayman Chemical

Product number: 19171
Product name: PF-4800567
Purity: ≥98%
Packaging: 25mg
Price: $530
Updated: 2024/03/01

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PF 4800567 hydrochloride Chemical Properties,Usage,Production

Description

PF-4800567 is a selective inhibitor of casein kinase 1ε (CK1ε; IC₅₀ = 32 nM) with greater than 20-fold selectivity over CK1δ. It blocks CK1ε-mediated PER3 nuclear localization and PER2 degradation, both of which are proteins important for maintaining circadian rhythms in cells. PF-4800567 has been used in the study of the CK1 enzymes in the regulation of circadian rhythm and is also reported to have neuroprotective effects.

Uses

PF 4800567 is a selective casein kinase 1ε inhibitor; displays 22-fold greater potency towards CK1ε than CK1δ (IC50 values are 32 and 711 nM for CK1ε and CK1δ respectively). ATP competitive. Displays minimal effect on the circadian clock.

Definition

ChEBI: PF-4800567 is a pyrazolopyrimidine that is 1H-pyrazolo[3,4-d]pyrimidin-4-amine which is substituted at positions 1 and 3 by tetrahydro-2H-pyran-4-yl and (m-chlorophenoxy)methyl groups, respectively. It is a selective inhibitor of the epsilon isoform of casein kinase 1 (CK1epsilon). It has a role as an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor. It is a pyrazolopyrimidine, a member of monochlorobenzenes, an aromatic ether and a member of oxanes.

in vivo

PF-4800567 (100 mg/kg, s.c.) is rapidly absorpted and distributed in plasma and brain of mice^[1].

IC 50

CKIδ: 711 nM (IC₅₀)

References

[1] KEVIN M WALTON. Selective inhibition of casein kinase 1 epsilon minimally alters circadian clock period.[J]. Journal of Pharmacology and Experimental Therapeutics, 2009, 330 2: 430-439. DOI: 10.1124/jpet.109.151415
[2] QING-JUN MENG. Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2010: 15240-15245. DOI: 10.1073/pnas.1005101107
[3] DANIEL I. PEREZ Ana M Carmen Gil. Protein kinases CK1 and CK2 as new targets for neurodegenerative diseases[J]. Medicinal Research Reviews, 2011, 31 6: 924-954. DOI: 10.1002/med.20207

PF 4800567 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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1188296-52-7, PF 4800567 hydrochlorideRelated Search:

3-[(3-Chlorophenoxy)Methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine Hydrochloride

PF 4800567

3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

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Casein Kinase,PF4800567,inhibit,PF-4800567,PF 4800567,Inhibitor

PF-4800567, 10 mM in DMSO

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1188296-52-7