ChemicalBook > CAS DataBase List > PF-2545920

PF-2545920

Product Name: PF-2545920
CAS No.: 1292799-56-4
Chemical Name: PF-2545920
Synonyms: CS-114;PF-2545920;Mardepodect;PF-2545920 USP/EP/BP;Mardepodect (PF-2545920);[11C]MP 10, 10 mM in DMSO;Mardepodect PF-2545920 PF2545920;2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline;2-[[4-[1-(Methyl-11C)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxy]methyl]quinoline;2-((4-(1-(Methyl-11C)-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)quinoline
CBNumber: CB32561490
Molecular Formula: C25H20N4O
Formula Weight: 392.4525
MOL File: 1292799-56-4.mol

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PF-2545920 Property

storage temp.: Store at -20°C
solubility: insoluble in H2O; ≥19.35 mg/mL in DMSO; ≥99.8 mg/mL in EtOH
form: solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology

Product number: A4325
Product name: PF-2545920
Packaging: 5mg
Price: $189
Updated: 2021/12/16

ApexBio Technology

Product number: A4325
Product name: PF-2545920
Packaging: 10mM(in 1mL DMSO)
Price: $240
Updated: 2021/12/16

ApexBio Technology

Product number: A4325
Product name: PF-2545920
Packaging: 10mg
Price: $259
Updated: 2021/12/16

ApexBio Technology

Product number: A4325
Product name: PF-2545920
Packaging: 50mg
Price: $679
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb181061
Product name: PF-2545920
Purity: >98%
Packaging: 100mg
Price: $912.9
Updated: 2021/12/16

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PF-2545920 Chemical Properties,Usage,Production

Biological Activity

pf-2545920 is an inhibitor of phosphodiesterase 10a (pde10a) with ic50 value of 0.37nm [1].pde10a is highly expressed in the medium spiny neurons of the striatum and regulates both cgmp and camp. the pde10a inhibitors are believed to regulate cyclic nucleotide signaling in the cortices-triatothalamic circuit. previous inhibitors of pde have potential therapeutic utility but also have potential safety risks due to off-target pde inhibition. thereby pf-2545920 is developed as a more selective inhibitor. pf-2545920 is shown to be efficacious both in vitro and in vivo with improved penetration in cns. it has excellent in vivo efficacy in neurochemical elevation of cyclic nucleotides and in models predictive of antipsychotic activity. administration of pf-2545920 to mice can cause increase in striatal cgmp with the minimal effective dose at about 1mg/kg [1].

target

PDE10A

References

[1] verhoest pr, chapin ds, corman m, fonseca k, harms jf, hou x, marr es, menniti fs, nelson f, o'connor r, pandit j, proulx-lafrance c, schmidt aw, schmidt cj, suiciak ja, liras s. discovery of a novel class of phosphodiesterase 10a inhibitors and identification of clinical candidate 2-[4-(1-methyl-4-pyridin-4-yl-1h-pyrazol-3-yl)-phenoxymethyl]-quinoline (pf-2545920) for the treatment of schizophrenia. j med chem. 2009 aug 27;52(16):5188-96.

PF-2545920 Preparation Products And Raw materials

Raw materials

Preparation Products

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PF-2545920 Suppliers

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1292799-56-4, PF-2545920Related Search:

Nicotinamide Tosyl chloride PD 173074 Roflumilast MK-2206 2HCl Torin 1 Pictilisib Dabrafenib

PF-2545920

2-[[4-[1-(Methyl-11C)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxy]methyl]quinoline

2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline

Mardepodect

CS-114

Mardepodect (PF-2545920)

PF-2545920 USP/EP/BP

Mardepodect PF-2545920 PF2545920

[11C]MP 10, 10 mM in DMSO

2-((4-(1-(Methyl-11C)-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)quinoline

1292799-56-4

Inhibitors

Inhibitor